Amir Baghbanzadeh

Tabriz University of Medical Sciences

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Behzad Baradaran

Tabriz University of Medical Sciences

Ahad Mokhtarzadeh

Tabriz University of Medical Sciences

Khalil Hajiasgharzadeh

Tabriz University of Medical Sciences

Leili Aghebati‐Maleki

Tabriz University of Medical Sciences

Nicola Silvestris

Istituti di Ricovero e Cura a Carattere Scientifico

Afshin Derakhshani

Istituto Tumori Bari

Elham Baghbani

Tabriz University of Medical Sciences

Behzad Baradaran

Tabriz University of Medical Sciences

Zahra Asadzadeh

Tabriz University of Medical Sciences

Nima Hemmat

Tabriz University of Medical Sciences

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Tabriz University of Medical Sciences

180

University of Tabriz

Tehran University of Medical Sciences

Biotechnology Research Center

Shahid Beheshti University of Medical Sciences

Islamic Azad University of Tabriz

Iran University of Medical Sciences

Tarbiat Modares University

University of Tehran

University of California, Los Angeles

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Recent clinical findings on the role of kinase inhibitors in COVID-19 management

Life Sciences (2022)

Zahra Malekinejad Amir Baghbanzadeh Ailar Nakhlband Behzad Baradaran Sevda Jafari

Cytokine Storm

10.1016/j.lfs.2022.120809

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Citations (12)

Restoration of miR-193a-5p and miR-146 a-5p Expression Induces G1 Arrest in Colorectal Cancer through Targeting of MDM2/p53

Advanced Pharmaceutical Bulletin (2019)

Saeed Noorolyai Elham Baghbani Leili Aghebati‐Maleki Amir Baghbanzadeh Dariush Shanehbansdi

Purpose: Colorectal cancer (CRC) remains a universal and lethal cancer owing to metastatic and relapsing disease. Currently, the role of microRNAs has been checked in tumorigeneses. Numerous studies have revealed that between the tumor suppressor miRNAs, the reduced expression of miR-146a-5p and -193a-5p in several cancers including CRC tissues are related with tumor progression and poor prognosis of patients. The purpose of this study is to examine the role of miR-146 a-5p and -193 a-5p in CRC cell cycle progression. Methods: The miR-193a-5p and -146 a-5p mimics were transfected into HT-29 CRC cells via jetPEI transfection reagent and their impact was assessed on p53, cyclin B, and NF-kB gene expression. The inhibitory effect of these miRNAs on cell cycle was assessed by flow cytometry. The consequence of miR-193a-5p and miR-146 a-5p on the protein expression level of Murine double minute 2 (MDM2) was assessed by western blotting. Results: miR193a-5p and -146a-5p regulated the expression of MDM2 protein and p53, cyclin B, and NF-kB gene expression in CRC cells. Treatment of HT-29 cells with miRNA-146a-5p and -193a-5p induced G1 cell cycle arrest. Conclusion: The findings of our study suggest that miR146a-5p and -193a-5p may act as a potential tumor suppressor by their influence on cell cycle progression in CRC cells. Thus, miRNA-146a-5p and -193a-5p restoration may be recommended as a potential therapeutic goal in the treatment of CRC patients.

10.15171/apb.2020.017

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Citations (28)

Molecular mechanisms of breast cancer chemoresistance by immune checkpoints

Life Sciences (2020)

Narges Dastmalchi Reza Safaralizadeh Amir Baghbanzadeh Khalil Hajiasgharzadeh Elmira Roshani Asl

Immune checkpoint

10.1016/j.lfs.2020.118604

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The cross-talk between tumor-associated macrophages and tumor endothelium: Recent advances in macrophage-based cancer immunotherapy

Biomedicine & Pharmacotherapy (2021)

Ali Baradaran Zahra Asadzadeh Nima Hemmat Amir Baghbanzadeh Mahdi Abdoli Shadbad

Tumor-associated macrophages (TAMs) are among the abundant cell populations of the tumor microenvironment (TME), which have pivotal roles in tumor development, chemoresistance, immune evasion, and metastasis. Growing evidence indicates that TAMs and the cross-talk between TAMs and tumoral endothelial cells can substantially contribute to tumor angiogenesis, which is considered a vital process for cancer development. Besides, tumoral endothelial cells can regulate the leukocyte infiltration to the TME in solid cancers and contribute to immune evasion. Therefore, targeting the immunosuppressive TAMs and the cross-talk between them can be a promising strategy for improving anti-tumoral immune responses. This review aims to summarize the biology of TAMs, their recently identified roles in tumor development/angiogenesis, and recent advances in macrophage-based cancer immunotherapy approaches for treating cancers.

Tumor-associated macrophage

Cancer Immunotherapy

10.1016/j.biopha.2021.112588

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Citations (23)

The Effect of Micro RNA-34a and carboplatin combination on the inducing apoptosis of Breast Cancer Cell line

Research Square (Research Square) (2021)

Sajjad Eslamkhah Nazila Alizadeh Sahar Safaei Mohammad Amini Ahad Mokhtarzadeh

Abstract Aim : Breast cancer (BC) has been classified among the main causes of death owing to females' cancer. Carboplatin is a platinum-based chemotherapeutic drug that is an important treatment option for BC. But high and frequent doses of carboplatin usually reducing the reaction of cancer cells to medication. There is an immediate need to establish methods for increasing the carboplatin susceptibility to BC cells. For instance, micro RNAs (miRNAs) such as MiR34a demonstrate significant potential. Considering that, this research was planned to explore the better clinical effect and underlying mechanism of miR-34a as a possible tumor inhibitor and drug resistance regulator in compound with carboplatin chemotherapy drug in the cell lines of BC in humans. Methods : MCF-7 cell line was transfected with miR-34a to perform functional analyses. Subsequently, the MTT assay was applied to assess cell viability. Cell viability and cell death associated gene expression amounts including Bax, Bcl-2, caspase-3, MDR1, P53, and mir34-a, were examined through real-time quantitative PCR. Results : Findings showed that miR-34a upregulation significantly decreased MCF7 cell viability in comparison with control group. Furthermore, separate treatment of cells with miR-34a mimics and carboplatin could significantly increase Bax, Caspase-3, P53, and decrease in Bcl-2 mRNA expression levels evaluated to the non-treated group. Moreover, by reduction in expression levels of the MDR1 gene, BC cells' reaction to carboplatin has increased via miR-34a. Conclusion : In line with the findings, it could be inferred that miR-34a may improve the responsiveness of breast cancer cells to carboplatin chemotherapy with downregulation of MDR1.

Carboplatin

Viability assay

MTT assay

10.21203/rs.3.rs-289066/v1

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Citations (1)

The potentials of immune checkpoints for the treatment of blood malignancies

Critical Reviews in Oncology/Hematology (2020)

Mohsen Alizadeh Ali Safarzadeh Seyed Ali Hoseini Reza Piryaei Behzad Mansoori

Blood cancer

Immune checkpoint

Cancer Treatment

10.1016/j.critrevonc.2020.103031

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Citations (5)

Recent progress in the design of DNA vaccines against tuberculosis

Drug Discovery Today (2020)

Youssof Sefidi-Heris Abolfazl Jahangiri Ahad Mokhtarzadeh Mohammad‐Ali Shahbazi Saeed Khalili

Tuberculosis vaccines

10.1016/j.drudis.2020.09.005

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Citations (22)

Targeting Pd-L1 Combined with Paclitaxel Hampers Gastric Cancer Progression by Modulating Cell Proliferation, Apoptosis, and Migration

Elaheh Zafari Amir Baghbanzadeh Ahad Mokhtarzadeh Leili Aghebati‐Maleki Elham Baghbani

10.2139/ssrn.4894921

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The role of microRNAs involved in PI3‐kinase signaling pathway in colorectal cancer

Journal of Cellular Physiology (2018)

Saeed Noorolyai Ahad Mokhtarzadeh Elham Baghbani Milad Asadi Amir Baghbanzadeh

In recent decades, cancer has been one of the most important concerns of the human community, which affects human life from many different ways, such as breast, lung, colorectal, prostate, and other cancers. Colorectal cancer is one of the most commonly diagnosed cancers in the world that has recently been introduced as the third leading cause of cancer deaths in the world. microRNAs have a very crucial role in tumorgenesis and prevention of cancer, which plays a significant role with influencing various factors through different signaling pathways. Phosphoinositide 3 (PI3)-kinase/AKT is one of the most important signaling pathways involved in the control and growth of tumor in colorectal cancer, through important proteins of this pathway, such as PTEN and AKT, that they can perform specific influence on this process. Our effort in this study is to collect microRNAs that act as tumor suppressors and oncomirs in this cancer through PI3-kinase/AKT signaling pathway.

10.1002/jcp.27415

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Citations (28)

Regulation of immune responses through CD39 and CD73 in cancer: Novel checkpoints

Life Sciences (2021)

Elham Baghbani Saeed Noorolyai Dariush Shanehbandi Ahad Mokhtarzadeh Leili Aghebati‐Maleki

Purinergic Signalling

10.1016/j.lfs.2021.119826

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Citations (42)