Fabrice Monteau

Oniris

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Bruno Le Bizec

Laboratoire D'étude des Résidus et Contaminants Dans les Aliments

127

Jean‐Philippe Antignac

Laboratoire D'étude des Résidus et Contaminants Dans les Aliments

Gaud Dervilly

Oniris

François André

Centre National de la Recherche Scientifique

Emmanuelle Bichon

Laboratoire D'étude des Résidus et Contaminants Dans les Aliments

Frédérique Courant

Laboratoire HydroSciences Montpellier

Daniel Maume

École Normale Supérieure - PSL

Nora Cesbron

Oniris

Cyril Feidt

Université de Lorraine

Marie-Pierre Montrade

Ministère de l'Agriculture et de la Souveraineté alimentaire

Cooperative Institutions

Laboratoire D'étude des Résidus et Contaminants Dans les Aliments

Université Nantes Angers Le Mans

Centre National de la Recherche Scientifique

Oniris

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Nantes Université

École Normale Supérieure - PSL

École Nationale Vétérinaire de Toulouse

Inserm

Institut National de la Recherche Agronomique

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Ecdysteroids: one potential new anabolic family in breeding animals

Analytica Chimica Acta (2002)

Bruno Le Bizec Jean‐Philippe Antignac Fabrice Monteau François André

10.1016/s0003-2670(02)00874-7

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Citations (40)

Current applications and perspectives of ion mobility spectrometry to answer chemical food safety issues

TrAC Trends in Analytical Chemistry (2017)

Maykel Hernández‐Mesa Antoine Escourrou Fabrice Monteau Bruno Le Bizec Gaud Dervilly

Ion-mobility spectrometry

Software portability

Isobaric process

10.1016/j.trac.2017.07.006

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Citations (122)

Determination of a Large Set of β-Adrenergic Agonists in Animal Matrices Based on Ion Mobility and Mass Separations

Analytical Chemistry (2015)

Laure Beucher Gaud Dervilly Stéphanie Prevost Fabrice Monteau Bruno Le Bizec

While the coupling of traveling wave ion mobility spectrometry (TWIMS) and mass spectrometry is mainly reported for structural purposes, we studied its potential in enhancing compounds analysis such as growth promoters used in livestock animals at trace concentrations. β-Adrenergic agonists have been selected as model compounds since they exhibit a range of close physicochemical properties leading to analytical issues using classical approaches. In this paper, the potential of Synapt G2-S (Q-TWIM-TOF MS) has been investigated for sensitive and specific detection of a range of these synthetic phenethanolamines in various complex biological matrices (retina, meat, and urine) from bovine considered as relevant in the context of detecting β-adrenergic agonists use in animals. In particular, the specificity of the additional information provided by the TWIMS (i.e., collision cross section) together with the interest of the extra dimension of separation is discussed.

Ion-mobility spectrometry

10.1021/acs.analchem.5b01831

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Citations (36)

CCDC 886474: Experimental Crystal Structure Determination

The Cambridge Structural Database (2013)

Marieke Vansteelandt Elodie Blanchet Maxim Egorov Fabien Petit Loïc Toupet

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccyrfy1

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Detection and identification of anabolic steroids in bovine urine by gas chromatography—mass spectrometry

Analytica Chimica Acta (1993)

Bruno Le Bizec Marie-Pierre Montrade Fabrice Monteau François André

Solid phase extraction

Enzymatic Hydrolysis

10.1016/0003-2670(93)80283-q

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Citations (43)

Gas chromatographic–mass spectrometric identification of main metabolites of stanozolol in cattle after oral and subcutaneous administration

Journal of Chromatography B Biomedical Sciences and Applications (1997)

Véronique Ferchaud‐Roucher Bruno Le Bizec Marie-Pierre Montrade Daniel Maume Fabrice Monteau

Stanozolol

10.1016/s0378-4347(97)00124-2

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Citations (28)

Exposure assessment of fetus and newborn to brominated flame retardants in France: preliminary data

Molecular Nutrition & Food Research (2008)

Jean‐Philippe Antignac Ronan Cariou Daniel Maume Philippe Marchand Fabrice Monteau

Brominated flame retardants (BFR) are chemicals extensively used in many manufactured products to reduce the risk of fire, but also environmental pollutants. In order to assess the potential risk linked to these compounds in human, a French monitoring study was initiated to evaluate the exposure of fetus and newborn. A previously described multi-residue analytical method was used, for measuring the main classes of BFR (hexabromocyclododecane, tetrabromobisphenol-A, and tri- to deca-polybromodiphenylethers) in various biological matrices. These analyzed samples (maternal and umbilical serum, adipose tissue and breast milk) were collected on volunteer women during caesarean deliveries. Preliminary results obtained on 26 individuals (mother/newborn pairs) mainly demonstrated the presence of polybromodiphenylethers (PBDE) and tetrabromobisphenol A both in maternal and fetal matrices, and a possible risk of overexposure of newborns through breastfeeding. Contaminations levels were found globally in the ng/g lipid weight range, consistent with other published European data. Exposure results regarding highly brominated PBDE congeners (octa- to deca-BDE) appeared particularly informative and non-commonly reported, these compounds accounting for around 50% of the total PBDE load. Additional data collection and metabolism investigations are now on-going. A more complete statistical analysis related to this BFR exposition study will be provided in a next future.

Tetrabromobisphenol A

Hexabromocyclododecane

Brominated flame retardant

Exposure Assessment

10.1002/mnfr.200700077

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Citations (93)

Direct analysis in real time ‐ high resolution mass spectrometry (DART‐HRMS): a high throughput strategy for identification and quantification of anabolic steroid esters

Drug Testing and Analysis (2014)

Mickael Doué Gaud Dervilly Karinne Pouponneau Fabrice Monteau Bruno Le Bizec

High throughput screening is essential for doping, forensic, and food safety laboratories. While hyphenated chromatography‐mass spectrometry (MS) remains the approach of choice, recent ambient MS techniques, such as direct analysis in real time (DART), offer more rapid and more versatile strategies and thus gain in popularity. In this study, the potential of DART hyphenated with Orbitrap‐MS for fast identification and quantification of 21 anabolic steroid esters has been evaluated. Direct analysis in high resolution scan mode allowed steroid esters screening by accurate mass measurement (Resolution = 60 000 and mass error < 3 ppm). Steroid esters identification was further supported by collision‐induced dissociation (CID) experiments through the generation of two additional ions. Moreover, the use of labelled internal standards allowed quantitative data to be recovered based on isotopic dilution approach. Linearity (R 2 > 0.99), dynamic range (from 1 to 1000 ng mL ‐1 ), bias (<10%), sensitivity (1 ng mL ‐1 ), repeatability and reproducibility (RSD < 20%) were evaluated as similar to those obtained with hyphenated chromatography‐mass spectrometry techniques. This innovative high throughput approach was successfully applied for the characterization of oily commercial preparations, and thus fits the needs of the competent authorities in the fight against forbidden or counterfeited substances. Copyright © 2014 John Wiley & Sons, Ltd.

DART ion source

Orbitrap

Repeatability

Dart

10.1002/dta.1727

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Citations (39)

Toward a criterion for suspect thiouracil administration in animal husbandry

Food Additives & Contaminants Part A (2011)

Bruno Le Bizec Emmanuelle Bichon Yoann Deceuninck Stéphanie Prevost Fabrice Monteau

Thyreostats are growth-promoters banned in Europe since 1981. The identification of thiouracil (TU) in animal biological matrices can, however, no longer be systematically interpreted as a consequence of illegal administration. Indeed, some experimental results have indicated a causal link between cruciferous-based diet and the presence of TU in urine of bovines. The present study aims at investigating, on a large scale (n > 1300), the natural occurrence of thiouracil in urine samples collected from different animal species. TU was identified in main breeding animal species: bovine, porcine and ovine. The natural distribution of TU allowed proposing threshold values to differentiate compliant from suspect urine samples. Suggested values are 5.7 and 9.1 µg l(-1) in male adult bovines (6-24 months), 3.1 and 8.1 µg l(-1) in female adult bovines (6-24 months), 7.3 and 17.7 µg l(-1) in calves (<6 months), 3.9 and 8.8 µg l(-1) in female bovines (>24 months), and 2.9 and 4.1 µg l(-1) in porcines at a 95 and 99% confidence level, respectively.

Suspect

Animal Husbandry

Thiouracil

10.1080/19440049.2011.565483

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Citations (21)

Exposure assessment of French women and their newborn to brominated flame retardants: Determination of tri- to deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum

Environmental Pollution (2008)

Jean‐Philippe Antignac Ronan Cariou Daniel Zalko Alain Berrébi Jean‐Pierre Cravedi

Deca-

Breast tissue

Brominated flame retardant

10.1016/j.envpol.2008.07.008

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Citations (163)