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Coşkun Özer Demirtaş

Marmara University

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Feyza Gündüz

Marmara University

Yusuf Yılmaz

Recep Tayyip Erdoğan University

ÇK

Çağlayan Keklikkıran

Recep Tayyip Erdoğan University

Haluk Tarık Kani

Marmara University

Maurizia Rossana Brunetto

Azienda Ospedaliera Universitaria Pisana

Osman Cavit Özdoğan

Marmara University

Filippo Oliveri

University of Basel

YÖ

Yeşim Özen Alahdab

Marmara University

P. Colombatto

University of Pisa

G. Ricco

Azienda Ospedaliera Universitaria Pisana

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

Marmara University

Inserm

University Gastroenterology

Sun Yat-sen University

Shanghai Jiao Tong University

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Istituti di Ricovero e Cura a Carattere Scientifico

University College London

Istanbul University

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Can metastasis and recurrence be detected with Endocan and Vascular Endothelial Growth Factor in thyroid papillary cancer?

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) (2020)

Hande Peynirci Canan Ersoy Pınar Şişman Özlem Saraydaroğlu Coşkun Özer Demirtaş

Актуальность. Известно, что эндокан ассоциируется с различными типами злокачественных образований. Установлено, что фактор роста сосудистого эндотелия (VEGF) повышает экспрессию эндокана. Целью проведенного исследования было выявление наличия рецидива заболевания и/или метастазирования с помощью изменений эндокана и VEGF у пациентов с папиллярным раком щитовидной железы. Материалы и методы. Ретроспективное исследование проводилось с января 2005 года по декабрь 2015 года. Регистрировали пол, возраст, а также возраст пациента на момент диагностики тиреоидного рака, продолжительность наблюдения. Исследовательская группа была разделена на две подгруппы, которые составили пациенты с послеоперационными рецидивами и/или метастазами и без них. Патологические образцы обрабатывали Anti-ESM-1 и Anti-VEGFA, оценивали процент окрашивания и плотность. Результаты. Под наблюдением находились 59 пациентов (43 женщины и 16 мужчин). Средний возраст составил 52,39 ± 13,75 года. Установлено, что наиболее длинный диаметр опухоли составил 21,31 ± 20,20 мм, а продолжительность наблюдения — 37,24 ± 32,68 месяца. Среди пациентов 54,2 % имели рецидив и/или метастазирование, тогда как у 45,8 % рецидива или метастазирования не наблюдалось. Процент плотности эндокана составил 84,26 ± 20,32 и 2,56 ± 0,75 в группе рецидивов и/или метастазов, 75,56 ± 24,06 и 2,11 ± 1,02 — соответственно в группе без них. Плотность эндокана была выше у пациентов с рецидивом и/или метастазами, но не достигла статистической значимости (р = 0,077, р = 0,136 соответственно). Существенной разницы между двумя группами по окраске и плотности VEGF не обнаружено. Выводы. Необходимы дальнейшие исследования для оценки роли эндокана и фактора роста сосудистого эндотелия для прогнозирования рецидива и/или метастазирования папиллярной карциномы щитовидной железы.

10.22141/2224-0721.16.6.2020.215389

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Modeling hepatocellular carcinoma cells dynamics by serolo-gical and imaging biomarkers in patients with response to sorafenib and/or regorafenib

Digestive and Liver Disease (2021)

P. Colombatto Coşkun Özer Demirtaş G. Ricco L. Civitano Piero Boraschi

Regorafenib

Complete response

10.1016/j.dld.2020.12.095

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Evaluation of the Impact of Metabolic Syndrome on Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease

The Turkish Journal of Gastroenterology (2021)

Haluk Tarık Kani Coşkun Özer Demirtaş Çağlayan Keklikkıran İlkay Ergenç Shahin Mehdiyev

Metabolic syndrome (MS) is a condition that consists of several disorders, and the individual impact of these disorders on metabolic dysfunction-associated fatty liver disease (MAFLD) is still not clear in a combined diagnosis of MS. In this study, we aimed to investigate the effect of MS on advanced fibrosis in patients with MAFLD.

10.5152/tjg.2021.20512

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Kronik hepatit C hastalarında siroz gelişiminin retrospektif değerlendirmesi

Coşkun Özer Demirtaş

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External validation of the Toronto hepatocellular carcinoma risk index in Turkish cirrhotic patients

Journal of Hepatology (2020)

Coşkun Özer Demirtaş Feyza Gündüz Haluk Tarık Kani Çağlayan Keklikkıran Yeşim Özen Alahdab

10.1016/s0168-8278(20)31263-0

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Programmed Cell Death 1 and Hepatocellular Carcinoma: An Epochal Story

Journal of Gastrointestinal Cancer (2021)

Coşkun Özer Demirtaş Feyza Gündüz

Immune checkpoint

10.1007/s12029-021-00758-z

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Psychometric test compliance of patients with cirrhosis in the diagnosis of minimal hepatic encephalopathy

The Turkish Journal of Gastroenterology (2019)

Cansu Gur Beyhan Hirik B. Sahan Feyza Ustuner Canberk Sami Başıbüyük

Hepatic Encephalopathy

Psychometric tests

10.5152/tjg.2019.63

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ALBI grade: Evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma

JHEP Reports (2021)

Coşkun Özer Demirtaş Antonio D’Alessio Lorenza Rimassa Rohini Sharma David J. Pinato

Hepatocellular carcinoma (HCC) usually arises in the context of a chronically damaged liver. Liver functional estimation is of paramount importance in clinical decision making. The Child-Pugh score (CPS) can be used to categorise patients into 3 classes (A to C) based on the severity of liver functional impairment according to 5 parameters (albumin, bilirubin, prothrombin time, presence of ascites and hepatic encephalopathy). The albumin-bilirubin (ALBI) grade has emerged as an alternative, reproducible and objective measure of liver functional reserve in patients with HCC, defining worsening liver impairment across 3 grades (I to III). The ALBI score can identify different subgroups of patients with different prognoses across the diverse Barcelona Clinic Liver Cancer stages and CP classes, making it an appealing clinical predictor. In patients treated with potentially curative approaches (resection, transplantation, radiofrequency ablation, microwave ablation), ALBI grade has been shown to correlate with survival, tumour relapse, and post-hepatectomy liver failure. ALBI grade also predicts survival, toxicity and post-procedural liver failure in patients treated with transarterial chemoembolisation, radioembolisation, external beam radiotherapy as well as multi-kinase inhibitors (sorafenib, lenvatinib, cabozantinib, regorafenib) and immune checkpoint inhibitor therapy. In this review, we summarise the body of evidence surrounding the role of ALBI grade as a biomarker capable of optimising patient selection and therapeutic sequencing in HCC.

Lenvatinib

Regorafenib

Hepatic Encephalopathy

Liver Cancer

Cabozantinib

10.1016/j.jhepr.2021.100347

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Urban-Rural Comparison of Obesity and Related Metabolic Disorders in Southern Turkey

Turkish Journal of Family Medicine & Primary Care (2020)

Coşkun Özer Demirtaş

Introduction: Once considered a high-income country problem, obesity is now on the rise in low and middle-income countries, particularly in urban settings. The aim of this study is to estimate the distribution of obesity and related metabolic morbidities between rural and urban regions of Adana. Materials and Methods: 545 consecutive patients, applied to Pozantı State Hospital Internal Medicine outpatient clinic between June-September 2017 were enrolled. Diabetes mellitus and/or hypertension and/or hyperlipidemia are defined as metabolic comorbid condition (MCC). Participants living at Pozantı were named locals, and those living in Adana city center were named springers. Results: 351 (64.4%) participants were from Pozantı and 194 (35.6%) were from Adana city center. The median Body-mass index (BMI) of the study population was 29.1 (17.5-48.8) kg/m2. Springers had slightly higher, but statistically insignificant BMI compared to locals (28.7 kg/m2 vs. 29.6 kg/m2 respectively, p=0.078). MCC was more frequent in springers (64.4% vs 54.1%, p= 0.02). Univariate analysis revealed that; springers (p=0.02), age>65 (p=0.00), patients with BMI>25 kg/m2 (p=0.001) and uric acid>7 mg/dl (p=0.001) is associated with MCC. Multivariate analysis displayed the association of BMI>25 kg/m2, age between 65-79 and uric acid >7 mg/dl with MCC independently. Conclusion: Obesity exists approximately one in every three cases and metabolic morbidities are observed in nearly half of the patients who applied to internal medicine outpatient clinic. The growing burden of obesity and related metabolic disorders in our region points to urgent preventive strategies on a national scale. Giriş: Bir zamanlar yüksek gelirli ülkelerin sorunu olarak görülen obezitenin, özellikle kent yaşamının yoğun olduğu düşük ve orta gelirli ülkelerde sıklığı giderek artmaktadır. Bu çalışmanın amacı, Adana’nın kırsal ve kentsel bölgeleri arasında obezite ve buna bağlı metabolik hastalıkların dağılımını belirlemektir. Materyal ve Metod: Haziran-Eylül 2017 tarihleri arasında Pozantı Devlet Hastanesi İç Hastalıkları polikliniğine başvuran 545 ardışık hasta dahil edildi. Diyabet, hipertansiyon ve/veya hiperlipidemi tanılarının varlığı metabolik komorbid durum (MKD) olarak tanımlandı. Pozantı ilçesinde yaşayan bireyler yerli, Adana şehir merkezinde yaşayan bireyler ise yaylacı olarak tanımlandı. Bulgular: Katılımcıların 351 (%64,4)’i Pozantı, 194 (%35,6)’ü Adana kent merkezinden idi. Çalışma popülasyonunun ortanca vücut-kitle indeksi (VKİ) 29,1 (17,5-48,8) kg/m2 saptandı. Yaylacılarda, yerlilere göre istatistiksel olarak anlamlı olmayan VKİ yüksekliği saptandı (sırasıyla 28,7 kg/m2 vs. 29,6 kg/m2, p=0,078). MKD, yaylacılarda daha sık görülmüştür (%64,4 vs. %54,1, p=0,02). Tek değişkenli analizler sonucunda; yaylacılarda (p=0,02), yaş>65 (p=0,00), VKİ>25 kg/m2 (p=0,001), ürik asit > 7 mg/dl (p=0,001) olanlarda MKD daha sık görülmüştür. Çok değişkenli analizler sonucunda ise; VKİ>25 kg/m2, 65-79 yaş arasında olmak ve ürik asit düzeyi > 7 mg/dl bağımsız olarak MKD varlığı ile ilişkili saptandı. Sonuç: İç Hastalıkları polikliniğine başvuran hastalardan her üç kişiden birinde obezite, ve her iki kişiden birinde de metabolik komorbiditeler bulunmaktadır. Bölgemizdeki artan obezite ve ilişkili metabolik problemler, ulusal ölçekte acil önleyici müdahale gerekliliğini ortaya koymuştur.

Univariate analysis

Outpatient clinic

Hyperlipidemia

Rural population

10.21763/tjfmpc.692846

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Convenient chronic hepatitis B candidates for antiviral cessation and retreatment after relapse: When and who?

The Turkish Journal of Gastroenterology (2018)

Coşkun Özer Demirtaş Osman Cavit Ozdogan

Chronic hepatitis B (HBV) infection has been treated with nucleos(t)ide analogs (NAs) successfully in recent years, especially with entecavir (ETV) and tenofovir disoproxil fumarate (TDF) with their ability to inhibit the HBV replication, normalize the laboratory, and improve the histology in nearly all patients (1,2).Unfortunately, NAs can't eradicate HBV from the liver, and they rarely eliminate the hepatitis B surface antigen (HBsAg), which is an ideal but a remote and unrealistic target for the discontinuation of NAs therapy.

Entecavir

Discontinuation

Hepatitis B

Tenofovir

HBeAg

10.5152/tjg.2018.290918

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