Alf Lamprecht

University of Bonn

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Yann Pellequer

Université de franche-comté

Arnaud Béduneau

Université de franche-comté

Brice Moulari

Université de franche-comté

Maryam A. Shetab Boushehri

Ain Shams University

Nathalie Ubrich

Laboratoire de Chimie Physique et Microbiologie pour l'Environnement

Philippe Maincent

Cibles thérapeutiques, formulation et expertise préclinique du médicament

Claus‐Michael Lehr

University Medical Center Hamburg-Eppendorf

Mona M.A. Abdel-Mottaleb

Ain Shams University

Salma N. Tammam

German University in Cairo

Dirk Dietrich

University Hospital Bonn

Cooperative Institutions

University of Bonn

116

Inserm

University Hospital Bonn

Université de franche-comté

Centre National de la Recherche Scientifique

Université Bourgogne Franche-Comté

Université d'Angers

Heidelberg University

Université de Lorraine

Saarland University

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Characterization of microcapsules by confocal laser scanning microscopy: structure, capsule wall composition and encapsulation rate

European Journal of Pharmaceutics and Biopharmaceutics (2000)

Alf Lamprecht Ulrich F. Schäfer Claus‐Michael Lehr

Coacervate

Gum arabic

Capsule

10.1016/s0939-6411(99)00063-6

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Citations (144)

The relevance of supersaturation and solubilization in the gastrointestinal tract for oral bioavailability: An in vitro vs. in vivo approach

International Journal of Pharmaceutics (2021)

Álvaro López Mármol Alexander Denninger Antoine Touzet Katharina Dauer Tim Becker

Supersaturation

10.1016/j.ijpharm.2021.120648

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Citations (7)

Immunoadsorption of Alloantibodies onto Erythroid Membrane Antigens Encapsulated into Polymeric Microparticles

Pharmaceutical Research (2007)

Valérie Hoffart Philippe Maincent Alf Lamprecht Véronique Latger‐Cannard Véronique Regnault

Immunoadsorption

Microparticle

Isoantibodies

Alloimmunity

10.1007/s11095-007-9340-2

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Citations (3)

Increase in the Vascular Residence Time of Propranolol-Loaded Nanoparticles Coated with Heparin

Journal of Nanoscience and Nanotechnology (2008)

M. Socha Alf Lamprecht Fatima El Ghazouani Emeric Emond Philippe Maincent

Propranolol-HCI incorporated nanoparticles prepared with a blend of a polyester and a polycationic polymer and coated or not with a low molecular weight heparin by electrostatic interactions were prepared by emulsification followed by solvent evaporation. The mean diameter was 388 and 357 nm for coated and uncoated nanoparticles, respectively, and the entrapment efficiency ranged from 20 to 32%. Coated nanoparticles were negatively-charged, whereas uncoated nanoparticles displayed a positive zeta potential (+30 mV). After intravenous administration to rabbits of propranolol-HCI solution and propranolol-loaded nanoparticles coated or not with heparin, pharmacokinetic data revealed that coated nanoparticles exhibited a prolonged blood residence time. It can be concluded that the hydrophilic layer of heparin at the surface of nanoparticles conferred stealth properties which probably reduce the phagocytosis process and avoid immediate uptake by the mononuclear phagocytic system.

Zeta potential

Suspension

10.1166/jnn.2008.081

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Citations (12)

Assessment of joint pharmacokinetics and consequences for the intraarticular delivery of biologics

Journal of Controlled Release (2022)

Tobias Siefen Simon Bjerregaard Camilla Borglin Alf Lamprecht

Biopharmaceutical

10.1016/j.jconrel.2022.06.015

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Citations (15)