Raffaella Dainese

Centre Hospitalier de Bigorre

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Thierry Piche

Centre Hospitalier Universitaire de Nice

Xavier Hébuterne

Centre Hospitalier Universitaire de Nice

T. Piche

Film Studies Association of Canada

Mylène Vivinus-Nébot

Centre Hospitalier Universitaire de Nice

Eugènia Mariné–Barjoan

Centre Hospitalier Universitaire de Nice

M. Vivinus

Hôpital l'Archet

Marie‐Christine Saint‐Paul

Hôpital Pasteur

Vassilia Théodorou

Université de Toulouse

Rodolphe Anty

Université Côte d'Azur

Alicia Granja-Navacerrada

Hospital Universitario de Fuenlabrada

Cooperative Institutions

Inserm

Université Côte d'Azur

Centre Hospitalier Universitaire de Nice

Hôpital l'Archet

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

University of Padua

Tokyo Medical and Dental University

Universitat Autònoma de Barcelona

Instituto de Salud Carlos III

Observatoire de la Côte d’Azur

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Role of CCL20-CCR6 axis and MMP9 in the mucosal inflammation and fibrosis in inflammatory bowel disease

HAL (Le Centre pour la Communication Scientifique Directe) (2015)

Orsolya Inczefi Tamás Molnár Anita Bálint Raffaella Dainese Mathilde Lévêque

MMP9

CCL20

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Citations (0)

[Uremic neuropathy: clinical evolution and therapeutic results in a 5-year period of observation].

PubMed (1982)

A Bernardi F Biasia P Scapin G Bucciante Raffaella Dainese

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Su2035 Functional Bowel Symptoms in Quiescent Inflammatory Bowel Diseases: Role of Epithelial Barrier Disruption and Low Grade Inflammation

Gastroenterology (2013)

Mylène Vivinus-Nébot Grégory Frin Hanene Bzioueche Raffaella Dainese Ghislaine Bernard

Inflammatory Bowel Diseases

10.1016/s0016-5085(13)61997-6

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Citations (3)

Influence of body posture on intestinal transit of gas

Gut (2003)

Raffaella Dainese

Background: Patients describe that body posture may affect their abdominal bloating, distension, and flatulence, but whether changes in position have objectively demonstrable effects, either beneficial or deleterious, has not been investigated. Aim: To determine the effect of body posture, upright versus supine, on intestinal transit of gas loads. Subjects: Eight healthy subjects without gastrointestinal symptoms. Methods: In each subject a gas mixture was continuously infused into the jejunum (12 ml/min) for three hours, and gas evacuation, clearance of a non- absorbable gaseous marker, perception, and abdominal girth were measured. Paired studies were randomly performed in each subject on separate days in the upright and supine positions. Results: In the upright position, intestinal gas retention was much smaller than when supine (13 (52) ml v 146 (75) ml retention at 60 minutes, respectively; p<0.05), and clearance of the gas marker was expedited (72 (10)% clearance v 49 (16)% at 60 minutes, respectively; p<0.05). The gas challenge test was well tolerated both in the upright and supine positions without abdominal distension. Conclusion: Body posture has a significant influence on intestinal gas propulsion: transit is faster in the upright position than when supine.

Supine position

Flatulence

Bloating

Body position

10.1136/gut.52.7.971

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Citations (54)

[Verification of the therapeutic efficacy of the gangliosides in the treatment of peripheral polyneuritis in alcoholics].

PubMed (1984)

Raffaella Dainese F Brazzo G Caniato R Hanau

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Citations (2)

Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome

Neurogastroenterology & Motility (2010)

T. Piche Philippe Ducrotté J M Sabaté Benoît Coffin Frank Zerbib

Background Patients with irritable bowel syndrome (IBS) and Crohn disease (CD) have impaired quality of life (Qol) associated with fatigue. Whether IBS-like symptoms have a similar impact on Qol and fatigue in quiescent CD than in IBS is currently unknown. Our aims were (i) to evaluate the prevalence of IBS-like symptoms in quiescent CD and (ii) to compare the impact of IBS-like symptoms on Qol and fatigue in both diseases. Methods A total of 92 quiescent CD, 40 IBS and 20 healthy subjects similar in age were included prospectively in five French academic centers. IBS symptoms were evaluated through the Rome III criteria. The severity of IBS symptoms, Qol, fatigue, depression and anxiety was measured using questionnaires (Francis Score, Likert scales, Fatigue Impact Scale, short-form Beck and Hospital Anxiety and Depression Scale). Key Results Irritable bowel syndrome-like symptoms were found in 42/92 (45.6%) patients with quiescent CD. The presence of IBS-like symptoms was associated with significant more profound alterations of Qol, high scores of fatigue, depression, but similar levels of anxiety. Compared to CD patients with IBS-like symptoms, IBS patients had more severe gastrointestinal symptoms and alterations of Qol, but similar scores of fatigue, depression and anxiety. In quiescent CD patients, fatigue was independently associated with the presence of IBS-like symptoms (OR = 1.018, 95% CI: 1.002–1.034, P = 0.02). Conclusions & Inferences The prevalence of IBS-like symptoms is elevated in quiescent CD. The presence of IBS-like symptoms in quiescent CD is probably associated with the range of fatigue/depression disorders. The mechanism underlying the occurrence of IBS-like symptoms in quiescent CD needs to be further explored.

Depression

Beck Anxiety Inventory

10.1111/j.1365-2982.2010.01502.x

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Citations (88)

Discrepancies Between Reported Food Intolerance and Sensitization Test Findings in Irritable Bowel Syndrome Patients

The American Journal of Gastroenterology (1999)

Raffaella Dainese E. Galliani F. De Lazzari Vincenza Di Leo R. Naccarato

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with clinical signs typical of "intestinal" food allergies or intolerance. The aim of this study was to characterize the clinical features of IBS patients suspected of suffering from adverse reactions to food.The study involved 128 consecutive IBS patients divided into four groups according to their main symptom on presentation at our outpatient clinic. A detailed medical history was recorded, paying particular attention to any allergies and reported intolerance to food. Each patient was screened for allergies; intestinal permeability tests was performed in randomly selected patients from different groups. Findings were analyzed using the chi2 test.Adverse reactions to one or more foods were reported by 80 patients (62.5%); skin prick tests (SPT) were positive in 67 patients (52.3%) with no significant differences between patients complaining of different symptoms. Patients who reported a food intolerance had more positive SPTs than those who did not (47 of 80 [58.7%] vs 20 of 48 [41.7%]); this difference was not statistically significant, although it suggests a trend (p < 0.0610). There was little consistency between the specific foods reported to cause intolerance and those resulting from the tests (11 of 80 patients, 13.7%). The intestinal permeability test was normal in 29 of 33 patients (87.9%).More than 50% of IBS patients were found sensitized to some food or inhalant without any typical clinical signs. Patients were unable to identify potentially offending foods. The lack of a correlation between SPT results and reported food allergies needs further investigation to clarify the pathophysiology and improve the diagnosis of intestinal food allergies.

Food intolerance

Intestinal Permeability

Outpatient clinic

10.1111/j.1572-0241.1999.01226.x

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Citations (143)

Characterization and potential effects of manipulated intestinal microflora and diet in irritable bowel syndrome patients: Preliminary study

Digestive and Liver Disease (2006)

Raffaella Dainese Francesc Casellas Stefania Silvi Alberto Cresci Annaluisa Cogo

Short Bowel Syndrome

10.1016/s1590-8658(06)80553-0

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Syndrome de l’intestin irritable avec constipation prédominante : actualités physiopathologiques

Hépato-Gastro & Oncologie Digestive (2014)

Dorsa Pishvaie Raffaella Dainese Laurianne DeGalleani M. Vivinus Xavier Hébuterne

Le syndrome de l’intestin irritable (SII) est le motif le plus frequent de consultation en gastroenterologie mais aussi en medecine generale. La frequence du SII atteindrait environ 4,7 % de la population francaise. Le diagnostic de SII repose sur les criteres cliniques de Rome III qui sont regulierement reactualises et associent des douleurs abdominales ou un inconfort digestif chronique ameliore par la defecation et associe a des troubles de la frequence et de la consistance des selles. Les malades atteints du SII avec constipation predominante (SII-C) representent environ un tiers des malades atteints de SII, l’alteration de la qualite de vie etant plus marquee qu’en cas de constipation chronique isolee. En dehors des troubles de la motricite digestive qui sont globalement similaires a ceux qui sont observes en cas de constipation chronique, les malades ayant un SII-C presentent des alterations complexes de l’axe cerveau-intestin, certaines d’entre elles pourraient etre plus specifiques du phenotype avec constipation predominante.

10.1684/hpg.2014.1039

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P017. Long-term stimulation with cytokines acquires irreversible accumulation of NF- B signaling in colonic epithelial cells

Journal of Crohn s and Colitis (2015)

Shuji Hibiya Kiichiro Tsuchiya K Fukushima Ryohei Hayashi Nobukatsu Horita

ILT3 expression, a surface receptor which is highly expressed on immature DC and renders them "tolerogenic", was significantly increased on DC post-EN by 55% (p<0.03).There were no significant differences in total lipid content of DC before and after treatment.Conclusions: Conclusion: Beneficial actions of EN in paediatric CrD may include the inhibition of DC maturation and regulating DC activity by increasing intracellular levels of the immunosuppressive adipokine, adiponectin.

10.1093/ecco-jcc/jju027.135

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