Geraldo Barroso Cavalcanti

Universidade Federal do Rio Grande do Norte

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Aldair Sousa Paiva

Universidade Federal do Rio Grande do Norte

Hugo Diogenes De Oliveira Paiva

Fundação Faculdade de Medicina

Rodrigo Villar Freitas

Universidade Federal do Rio Grande do Norte

Victor lima Soares

Laboratório DNA Center

Gustavo Henrique de Medeiros Oliveira

Universidade Estadual de Maringá

Valéria Sf Sales

Universidade Federal do Rio Grande do Norte

Frank Bahia

Dany Gkc Silva

Universidade Federal do Rio Grande do Norte

Taissa Moura Oliveira

Hospital Universitário Onofre Lopes

Raquel Ciuvalschi Maia

Instituto Nacional do Câncer

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Universidade Federal do Rio Grande do Norte

164

Universidade de São Paulo

Instituto Nacional do Câncer

Hospital Universitário Onofre Lopes

Universidade Federal do Rio Grande

Universidade Federal do Rio de Janeiro

Instituto Nacional del Cáncer

Universidade Federal de São Paulo

Fundação Oswaldo Cruz

Universidade Estadual de Campinas (UNICAMP)

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Updating recommendations of the Brazilian Group of Flow Cytometry (GBCFLUX) for diagnosis of acute leukemias using four-color flow cytometry panels

Hematology Transfusion and Cell Therapy (2021)

Miriam Perlingeiro Beltrame Elizabeth Xisto Souto Mihoko Yamamoto Felipe Magalhães Furtado Elaine Sobral da Costa

Flow cytometry has become an increasingly important tool in the clinical laboratory for the diagnosis and monitoring of many hematopoietic neoplasms. This method is ideal for immunophenotypic identification of cellular subpopulations in complex samples, such as bone marrow and peripheral blood. In general, 4-color panels appear to be adequate, depending on the assay. In acute leukemias (ALs), it is necessary identify and characterize the population of abnormal cells in order to recognize the compromised lineage and classify leukemia according to the WHO criteria. Although the use of eight- to ten-color immunophenotyping panels is wellestablished, many laboratories do not have access to this technology.In 2015, the Brazilian Group of Flow Cytometry (Grupo Brasileiro de Citometria de Fluxo, GBCFLUX) proposed antibody panels designed to allow the precise diagnosis and characterization of AL within available resources. As many Brazilian flow cytometry laboratories use four-color immunophenotyping, the GBCFLUX has updated that document, according to current leukemia knowledge and after a forum of discussion and validation of antibody panels.Recommendations for morphological analysis of bone marrow smears and performing screening panel for lineage (s) identification of AL were maintained from the previous publication. The lineage-oriented proposed panels for B and T cell acute lymphoblastic leukemia (ALL) and for acute myeloid leukemia (AML) were constructed for an appropriate leukemia classification.Three levels of recommendations (i.e., mandatory, recommended, and optional) were established to enable an accurate diagnosis with some flexibility, considering local laboratory resources and patient-specific needs.

Immunophenotyping

Cytometry

10.1016/j.htct.2021.04.001

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Citations (3)

A IMPORTÂNCIA DA RECICLAGEM E DA COLETA SELETIVA NA ÓTICA DE UMA COMUNIDADE DA CIDADE DE IMPERATRIZ - MA - BRASIL

Revista Integralização Universitária (2009)

Ezequiel Cavalcante Albuquerque Geraldo Barroso Cavalcanti Aurean de Paula Carvalho Anésio Mendes de Sousa Bianca Caroline da Cunha Germano

A segunda maior cidade do estado doMaranhao, Imperatriz, apresentaproblemas quanto a gestao dos residuossolidos, o que ocasiona riscos a saudep u b l i c a e a o me i o amb i e n t e ,principalmente pela ausencia deprogramas de reciclagem local. Assim opresente estudo objetivou avaliar osaspectos da reciclagem sob a otica dapopulacao local, bem como a existencia deprogramas no referido municipio.

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Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population

Molecular Cytogenetics (2013)

Erica Aires Gil Tirzah Braz Petta Lajus Taissa Maria Oliveira de Moura Juliana Mendonça Freire Andrea Luciana Araújo da Cunha Fernandes

Cytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native Brazilians, with the influx of Portuguese colonizers, Black African slaves, and recent European, Arab and Japanese immigration. The purpose of this prospective, multicentric study was to assess the sociodemographic, clinic and cytogenetic characteristics of the children treated for ALL in the Northeast region of Brazil. This study includes thirty patients between 4 months and 17 years old treated for ALL from January 1st, 2009 to November 30th, 2010. Cytogenetic analysis showed that in nineteen out of thirty patients (64%) presented some chromosome abnormalities, in which 53% corresponds to numerical abnormalities, 21% structural and numerical abnormalities, and 26% only structural changes. Moreover, seven patients presented complexes karyotype not yet described in the literature. Taken together these results show the importance of the cytogenetic analysis in ALL pediatric patients and illustrates that the studied population presented unexpected complexes karyotypes which were correlated to poor outcome. The results demonstrate the importance of banding cytogenetics for ALL diagnosis despite the use of most modern techniques such as FISH and aCGH, and provide reliable insight into the ALL in Brazil.

Ancestry-informative marker

10.1186/1755-8166-6-37

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Importance of Flow Cytometry in the Differential Diagnosis of Hairy Cell Leukemia in the State of Rio Grande Do Norte, Brazil

Blood (2020)

Aldair Sousa Paiva Alessandra Suelen Jardim Silva Victor lima Soares Gustavo Henrique de Medeiros Oliveira Lenilton Silva DA Silva Júnior

CD5

Immunophenotyping

Lymphocytosis

Terminal deoxynucleotidyl transferase

Immunoglobulin D

10.1182/blood-2020-143225

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Conventional Cytogenetic and Flow Cytometry Analysis in Pediatric Patients with Acute Lymphoblastic Leukemia (ALL) in a Brazilian Population

Blood (2017)

Erica Aires Gil Gioconda Dr Leão Andrea Lac Fernandes Roberto C Vasconcelos Aldair Sousa Paiva

Immunophenotyping

Acute lymphocytic leukemia

Hematology

10.1182/blood.v130.suppl_1.5011.5011

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Citations (1)

Molecular Analysis of Factor V, Prothrombin and Methylenetetrahydrofolate Redutase in Thrombolic Patients

Blood (2018)

Aldair Sousa Paiva Hugo Diogenes De Oliveira Paiva Geraldo Barroso Cavalcanti Gioconda Dr Leão Marcos Dias Leão

Factor V

Heterozygote advantage

Prothrombin G20210A

10.1182/blood-2018-99-118777

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USO DE HIDROGEL DE ÁLCOOL POLIVINÍLICO: REVISÃO BIBLIOGRÁFICA

Anuário Pesquisa e Extensão Unoesc Videira (2021)

Amanda Rayla dos Santos Macêdo Emanuel Monteiro Brasil José Heriberto de Oliveira Nascimento Geraldo Barroso Cavalcanti Dany Geraldo Kramer

O Alcool Polivinilico (PVA) e um polimero artificial biocompativel e importante sistema para a liberacao controlada de medicamentos. Assim, objetivou-se discorrer sobre a utilizacao do hidrogel de Alcool polivinilico (PVA) e suas aplicacoes microbiologicas. Trata-se de uma revisao de literatura integrativa sobre a tematica. Observou-se que o PVA pode ser mesclado com outros polimeros como a quitosana para a constituicao de hidrogel ou filme, na qual se incorporam antimicrobianos para liberacao controlada. Dentre os resultados favoraveis a atividade antimicrobiana de sistemas com PVA, o mais frequente foi contra as bacterias Staphylococcus aureus e Escherichia coli. Assim, esses sistemas demonstram-se alternativas de baixo custo e eficiencia para uso frente a resistencia bacteriana

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Contrasting features of MDR phenotype in leukemias by using two fluorochromes: Implications for clinical practice

Leukemia Research (2006)

Flavia da Cunha Vasconcelos Geraldo Barroso Cavalcanti Karina L. Silva Ernesto de Meis Jolie Kiemlian Kwee

P-glycoprotein

Rhodamine 123

Efflux

10.1016/j.leukres.2006.07.016

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Citations (36)