Bruce Coxon

National Institutes of Health

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Vince Pozsgay

National Institutes of Health

Sam A. Margolis

National Institute of Standards and Technology

Hassan S. El Khadem

American University

Rachel Schneerson

National Institutes of Health

Alexander J. Fatiadi

National Institute of Standards and Technology

Neşe Sari

Advanced Bioscience Laboratories (United States)

Joanna Kübler-Kiełb

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Robert M. Davidson

Cedars-Sinai Medical Center

John B. Robbins

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Robert Schaffer

European X-Ray Free-Electron Laser

Cooperative Institutions

National Institute of Standards and Technology

National Institutes of Health

Material Measurement Laboratory

National Institute of Standards

United States Department of Commerce

National Institute of Diabetes and Digestive and Kidney Diseases

Eunice Kennedy Shriver National Institute of Child Health and Human Development

United States Food and Drug Administration

National Research Council Canada

Purdue University West Lafayette

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The conformations of cyclic compounds in solution—II

Tetrahedron (1964)

Bruce Coxon Lars Häll

Vicinal

Coupling constant

Cyclohexane conformation

10.1016/s0040-4020(01)99168-9

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Citations (55)

Two-dimensional J-resolved proton nuclear magnetic resonance spectrometry of hydroxyl-coupled .alpha.- and .beta.-D-glucose

Analytical Chemistry (1983)

Bruce Coxon

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-dimensional J-resolved proton nuclear magnetic resonance spectrometry of hydroxyl-coupled .alpha.- and .beta.-D-glucoseBruce. CoxonCite this: Anal. Chem. 1983, 55, 14, 2361–2366Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/ac00264a036https://doi.org/10.1021/ac00264a036research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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BETA (programming language)

10.1021/ac00264a036

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Citations (20)

Investigation by NMR Spectroscopy and Molecular Modeling of the Conformations of Some Modified Disaccharide Antigens forShigella DysenteriaeType 1

Journal of Carbohydrate Chemistry (1997)

Bruce Coxon Neşe Sari Laurence A. Mulard Pavol Kováč Vince Pozsgay

Abstract The O-polysaccharide of Shigella dysenteriae type 1 is made up of multiple repeats of the linear tetrasaccharide 3)-α-L-Rhap-(1→2)-α-D-Galp-(1→3)-α-D-GlcpNAc-(1→3)-α-L-Rhap-(1→, for which the antigenic determinant for a murine monoclonal IgM antibody is the disaccharide α-L-Rhap-(1→2)-α-D-Galp. This disaccharide and various analogs have been studied by 2D NOESY, ROESY, and TOCSY NMR spectroscopy, in conjunction with proton spin-lattice relaxation rate measurements, restrained molecular mechanics, and restrained molecular dynamics with simulated annealing. It has been found that replacement of any single hydroxyl group in the determinant by a hydrogen atom, or replacement of any single hydroxyl group in the Gal residue by a fluorine atom has little if any influence on the conformation of the resulting derivatives.

Disaccharide

Tetrasaccharide

Carbohydrate conformation

Trisaccharide

10.1080/07328309708006549

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Citations (8)

A nitrogen-15 n.m.r. study of some dehydro-l-ascorbic bis(phenylhydrazone) derivatives

Carbohydrate Research (1981)

Hassan S. El Khadem Bruce Coxon

10.1016/s0008-6215(00)85257-x

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Citations (10)

Structural and conformational studies of 2,7-anhydro-l-glycero-β-d-manno-octulopyranose and its per-O-acetyl derivative

Carbohydrate Research (1990)

Michael G. Ambrose Alexander J. Fatiadi Bruce Coxon

Tricyclic

Quinazolinone

Derivative (finance)

Mitsunobu reaction

10.1016/0008-6215(90)80155-v

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Citations (1)

Laurance David Hall

Advances in carbohydrate chemistry and biochemistry (2011)

Bruce Coxon

Endowment

Graduate students

10.1016/b978-0-12-385520-6.00002-9

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Two-Dimensional Proton Chemical Shift Correlated NMR Spectroscopy of Digitoxose¹

Journal of Carbohydrate Chemistry (1984)

Bruce Coxon

Abstract The hydroxyl proton coupled 1H NMR spectra of solutions of β-d-digitoxopyranose and of an equilibrated mixture of the four ring forms of d-digitoxose in dimethylsulfoxide-d 6 have been assigned completely by two-dimensional, proton chemical shift correlated NMR spectroscopy and spin decoupling at 400 MHz. Analysis of resolution enhanced, one-dimensional 1H NMR spectra yielded an almost complete set of CH and OH proton-proton coupling constants for the four ring forms. The free aldehydo form of d-digitoxose in dimethylsulfoxide-d 6 solution has been detected by means of its characteristic H-l quartet at 6 9.687. Quantitative analysis of the equilibrated mixture of the five forms of d-digitoxose gave the composition:- α-pyranose, β-pyranose, α-furanose, β-furanose, aldehydo form, 11.2, 67.3, 8.4, 13.0, and 0.1%, respectively. The 4 C 1 chair conformations have been assigned to the α- and β-pyranose forms by analysis of the coupling constants and are discussed qualitatively in terms of their relative stabilities.

Pyranose

Furanose

Chemical shift

Proton NMR

Coupling constant

Carbon-13 NMR satellite

10.1080/07328308408057916

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Citations (12)

Utility of coupled-HSQC experiments in the intact structural elucidation of three complex saponins from Blighia sapida

Carbohydrate Research (2011)

Eugene P. Mazzola Ainsley Parkinson Edward J. Kennelly Bruce Coxon Linda Saxe Einbond

Aglycone

Proton NMR

Monosaccharide

10.1016/j.carres.2011.02.019

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Citations (27)

ChemInform Abstract: NITROGEN-15 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY OF NEOMYCIN B AND RELATED AMINOGLYCOSIDES

Chemischer Informationsdienst (1983)

Robert E. Botto Bruce Coxon

Neomycin

10.1002/chin.198322352

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Conjugates of Group A and W135 Capsular Polysaccharides ofNeisseria meningitidisBound to RecombinantStaphylococcus aureusEnterotoxin C1: Preparation, Physicochemical Characterization, and Immunological Properties in Mice

Infection and Immunity (2005)

Zhigang Jin Gregory A. Bohach Joseph Shiloach Scott E. Norris Darón I. Freedberg

Neisseria meningitidis groups A (GAM) and W135 capsular polysaccharides (CPs) were bound to recombinant Staphylococcus aureus enterotoxin C1 (rSEC). The CPs were activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate and then bound to adipic acid dihydrazide derivatives of rSEC. Syntheses were conducted with native GAM CP (GAMP), W135 CP (W135P), and ultrasonicated or hydrazine-treated W135P at various concentrations of reactants, pHs, and ionic strengths. The conjugates were characterized by compositional and serologic analyses, high-performance size-exclusion chromatography with multi-angle laser light scattering detection, and immunogenicity in 5- to 6-week-old mice. Conjugates injected subcutaneously in phosphate-buffered saline elicited immunoglobulin G (IgG) responses against their respective CPs and rSEC, whereas GAMP and W135P alone did not induce detectable CP antibodies. The O-acetyl content of W135P was low, and its removal had no adverse effect upon the conjugate's immunogenicity. Reduction of the molecular size of W135P by treatment with hydrazine improved the immunogenicity of W135P-rSEC. IgG anti-CP elicited by the conjugates showed complement-dependent bactericidal activity against their respective organisms, and IgG anti-rSEC neutralized the T-cell proliferative activity of native SEC. A bivalent formulation of GAMP-rSEC and W135P-rSEC elicited IgG anti-CP at comparable levels to those induced by the conjugates administered separately.

Conjugate

10.1128/iai.73.12.7887-7893.2005

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Citations (7)