Hiroyuki Kumamoto

Tohoku University

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Kiyoshi Ooya

Tohoku University

Tetsu Takahashi

Southern Tohoku General Hospital

Kensuke Yamauchi

Tohoku University

Atsumu Kouketsu

Tohoku University

Seishi Echigo

Tohoku University

M. Oikawa

Chiba Cancer Center

Yoshinaka Shimizu

Tohoku University

Hitoshi Miyashita

Tohoku University

Shinnosuke Nogami

Tohoku University

Kousuke Ohki

Japan Association for Development of Community Medicine

Cooperative Institutions

Tohoku University

212

European Foundation for the Study of Chronic Liver Failure

197

Tohoku University Hospital

The University of Tokyo

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Osaka University

Showa University

Centro de Investigación Biomédica en Red

Hospital Clínic de Barcelona

Kyushu University

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Immunohistochemical localization of c-myc oncogene protein correlated with malignancy of oral epithelium.

Japanese Journal of Oral Biology (1991)

Hiroyuki Kumamoto Kiyoshi Ooya Hironobu Sasano

10.2330/joralbiosci1965.33.315

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Citations (1)

Biodegradation behaviors of magnesium(Mg)-based alloy nails in autologous bone grafts: In vivo study in rabbit skulls

Journal of Applied Biomaterials & Functional Materials (2022)

Yuta Yanagisawa Yoshinaka Shimizu Toshiji Mukai Yuya Sano Kenji Odashima

In this study, autologous bone grafts using bone-fixing nails made of magnesium-zinc-calcium ternary alloys were performed using rabbit skulls.Two types of nails for bone fixation were prepared: 2.5 mm width, 3 mm length and 2.5 mm width, 2 mm length. A disk-shaped bone with a diameter of 5 mm was resected from the parietal bone and fixed with a 3 mm long nail. As a control group, a 2 mm long nail was driven into the existing bone. The rabbits were sacrificed at 1, 4, 12, and 24 weeks after surgery. The resected samples were observed with micro X-ray CT, and embedded in methyl methacrylate to prepare non-decalcified specimens. The in vivo localization of elements was examined using energy-dispersive X-ray spectroscopy (EDS).Micro X-ray CT images of samples showed volume reduction due to degradation in both the bone graft and control groups. No significant difference in the amount of degradation between the two groups was observed, however characteristic degradation processes were observed in each group. The samples stained with alizarin red S showed amorphous areas around the nails, which were considered as corrosion products and contacted directly with the newly formed bones. EDS analysis showed that corrosion products were mainly composed of magnesium and oxygen at an early stage, while calcium and phosphorus were detected on the surface layer during the long-term observation.The degradation speed of the magnesium alloy nails varied depending on the shapes of the nails and surrounding tissue conditions. A calcium phosphate layer was formed on the surface of magnesium alloy nails, suggesting that the degradation rate of the nail was slow.

10.1177/22808000221095230

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Mandibular osteomyelitis showing remarkable bone resorption in association with Entamoeba gingivalis infection: Report of two cases

Journal of Oral and Maxillofacial Surgery Medicine and Pathology (2022)

Tsuyoshi Kurobane Shiro Mori Hitoshi Miyashita Hiroyuki Kumamoto Tetsu Takahashi

Sequestrum

Periodontium

10.1016/j.ajoms.2022.08.006

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A case of giant synovial chondromatosis with severe condylar resorption

Japanese Journal of Oral & Maxillofacial Surgery (2014)

Jun Kurihara Hitoshi Miyashita Yoko Yagishita Hiroyuki Kumamoto Hiroshi Nagasaka

The patient, a 75-year-old man, was referred to our hospital because of discomfort and tenderness of the right temporomandibular joint （TMJ） in April 2010. Computed tomographic （CT） images revealed a large tumor, while 3-dimensional CT showed bone destruction and remarkable deformities in the right mandibular condyle. Surgery was scheduled for September 2010 for a clinical diagnosis of a right mandibular condyle tumor. The tumor was resected surgically by extraoral vertical ramus osteotomy with a simultaneous high condylectomy, and the pathologic diagnosis was synovial chondromatosis of the TMJ. The excised tumor comprised cartilage, and the surface of the mass was covered by a fibrous capsule. Severe condylar resorption and remarkable condylar deformity were confirmed. During the 2.5 years since surgery, periodic observations have shown no evidence of recurrent abnormalities in the TMJ.

Chondromatosis

Joint capsule

10.5794/jjoms.60.50

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A case of pseudogout of the temporomandibular joint with progression to the subcutis, diagnosed using ultrasound-assisted fine needle aspiration cytology

Japanese Journal of Oral & Maxillofacial Surgery (2022)

Tomonari Kajita Shinnosuke NOGAMI Kenji Odashima Miyashita Hitoshi Hiroyuki Kumamoto

Pseudogout is arthrosis caused by the deposition of calcium pyrophosphate dehydrate (CPPD), most cases of which present in the knee, wrist or hand. We report a case of pseudogout with widespread progression from the superior joint space of the temporomandibular joint (TMJ) to the subcutaneous region. A 72-year-old man was referred to our hospital with the chief complaint of swelling around the right TMJ. The interincisal distance was 48 mm without pain. There was no history of TMJ disorder, trauma or systemic joint disease. Computed tomography and magnetic resonance imaging revealed an approximately 20 mm neoplastic lesion outside the right condylar head. Ultrasound-guided fine needle aspiration showed that there were crystalline materials with weak birefringence in the neoplastic lesion, leading to a diagnosis of pseudogout. He underwent a removal of the tumorous mass under general anesthesia. The result of histopathologic examination was similar to the cytological finding. Clinical symptoms disappeared after surgery. There have been no signs of recurrence in over 1-year of follow-up.

Pseudogout

Chondrocalcinosis

10.5794/jjoms.68.77

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Multiple organ failure associated with extensive metastatic calcification in a patient with an intermediate state of human T lymphotropic virus type I (HTLV‐I) infection: Report of an autopsy case

Pathology International (1998)

Hiroyuki Kumamoto Ryo Ichinohasama Takashi Sawai Hiroshi Naganuma Y Furukawa

A patient with an intermediate state of human T lymphotropic virus type I (WLV‐I) infection and in whom autopsy showed multiple organ failure (MOP associated with extensive metastatic calcification in systemic organs is described. A 56‐year‐old man presented with signs and symptoms of advanced cardiac insufficiency, respiratory disturbance and renal failure. Serologically, the anti‐human T lymphotropic virus type I (HTLV‐I) antibody tier and the levels of both calcium and parathyroid hormonerelated peptide (PTHrP) were dlstinctly elevated. These data suggested a diagnosis of adult T cell lymphoma/leukemia (ATLL). However, examination of a peripheral blood sample revealed only a few atypical lymphoid cells (3%) associated with mild leukocytosis (white blood cell count, 13.7 × 10 3 /mm 3 ). Lymph node swelling was systemic but mild, with some nodes up to 10 mm In diameter. The patient died of MOF. Adult T cell leukemla/lymphoma was unable to be diagnosed definitively because of the short duration of laboratory abnormalities and because of the discrepancy between the laboratory data and the magnitude of lymphoprollferation in both the lymph nodes and peripheral blood. At autopsy, the most conspicuous finding was extensive metastatic calcification in the multiple organs, including the heart, lungs, kidneys, tongue, liver, pancreas, spleen and systemic arterial walls. Very small numbers of medium‐sized atypical lymphoid cells admixed with small reactive lymphocytes were Identified in multiple organs, with no evidence of massive Infiltration. Molecular analyses could not detect monoclonal Integratlon of HTLV‐I provirus DNA or monoclonality of T cell lineage cells. Parathyroid hormone‐related peptide was demonstrated In the cytoplasm of the atypical lymphoid cells on lmmunohls‐tochemical examination. The bone trabeculae generally showed distinct evidence of resorption associated with marked proliferation of osteoclasts. These findings suggested that the hypercalcemia in the present case was categorized as humoral hypercalcemia of malignancy rather than local osteolytic hypercalcemia.

Leukocytosis

Metastatic calcification

10.1111/j.1440-1827.1998.tb03912.x

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Citations (23)

Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) and heat shock proteins (HSPs) in ameloblastomas

Journal of Oral Pathology and Medicine (2002)

Hiroyuki Kumamoto Takahiro Suzuki Kiyoshi Ooya

Abstract Background: To clarify the possible role of nitric oxide (NO) and stress proteins in oncogenesis and cytodifferentiation of odontogenic epithelium. Inducible NO synthase (iNOS) and heat shock proteins (HSPs) were analyzed in ameloblastomas as well as in tooth germs. Methods: Specimens of seven tooth germs, 36 benign ameloblastomas and five malignant ameloblastomas were examined by immunohistochemistry using antibodies against iNOS and 27‐, 60‐ and 70‐kDa HSPs (HSP27, HSP60 and HSP70). Results: Immunoreactivity for iNOS was detected in normal and neoplastic odontogenic epithelial cells and was higher in malignant ameloblastomas than in tooth germs and benign ameloblastomas. HSP27 was expressed constitutively in all odontogenic epithelial cells in tooth germs and benign and malignant ameloblastomas. Expression of HSP60 and HSP70 was detected in normal and neoplastic odontogenic epithelial cells and was prominent in cells neighboring the basement membrane. HSP60 reactivity showed no apparent difference between normal and neoplastic odontogenic epithelium, whereas HSP70 expression was slightly higher in benign and malignant ameloblastomas than in tooth germs. Conclusions: Activation of iNOS might be associated with malignant potential of epithelial odontogenic tumors. Elevated expression of HSP70 is considered to be involved in neoplastic transformation of odontogenic epithelial cells.

HSP60

Neoplastic transformation

Malignant Transformation

Hsp27

Odontogenic tumor

10.1034/j.1600-0714.2002.00014.x

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Citations (30)

Case report of mammary analog secretory carcinoma of the parotid gland

Pathology International (2011)

Shigemi Ito Eiichi Ishida Alena Skálová Kazuto Matsuura Hiroyuki Kumamoto

Mammary Analog Secretory Carcinoma (MASC) is a new entity of malignant salivary gland tumors that morphologically resembles mammary secretory carcinoma and carries the identical ETV6‐NTRK3 fusion gene. We report our first case of MASC in Japan occurring in the parotid gland of a 37‐year‐old female patient with a t (12; 15) (p13; q25) translocation. Histologically, the tumor was composed of monomorphic cuboidal cells with low‐grade vesicular nuclei and pale eosinophilic cytoplasm, and formed microcystic and tubular spaces with periodic acid‐Schiff‐positive secretion. Immunohistochemically, the tumor cells tested positive for cytokeratin, vimentin, and S‐100 protein. MASC is a morphological mimicker of acinic cell carcinoma, but is a distinct neoplasm characterized by a specific chromosomal translocation. An accumulation of similar case studies is mandatory in order to clarify biological behaviors.

Mammary carcinoma

Secretory IgA

10.1111/j.1440-1827.2011.02759.x

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Citations (47)

Assessment of protein expression and gene status of human epidermal growth factor receptor (HER) family molecules in ameloblastomas

Journal of Oral Pathology and Medicine (2012)

M. Oikawa Yasuhiro Miki Yoshinaka Shimizu Hiroyuki Kumamoto

To evaluate roles of human epidermal growth factor receptor (HER) family molecules in ameloblastomas, protein expression and gene status were analyzed in odontogenic tissues.Sixty five ameloblastomas, 10 dental follicles, and 11 dentigerous cysts were immunohistochemically examined with antibodies against epidermal growth factor receptor (EGFR) and HER2, HER3, and HER4. Amplification of EGFR and HER2 was evaluated by chromogenic in situ hybridization (CISH). In 18 ameloblastomas, EGFR exons 19 and 21 were analyzed by direct DNA sequencing.Immunohistochemical reactivity for EGFR and HER2, HER3, and HER4 was detected in odontogenic epithelium. Expression of EGFR and HER4 was remarkable in these odontogenic tissues, as compared with that of HER2 and HER3. The level of HER2 immunoreactivity was significantly lower in ameloblastomas than in dental follicles and dentigerous cysts. Follicular ameloblastomas showed significantly higher expression of HER2 and HER4 than plexiform ameloblastomas. Reactivity for EGFR and HER3 was slightly stronger in recurrent ameloblastomas than in primary ameloblastomas. CISH did not reveal obvious amplification of EGFR or HER2 in ameloblastomas; however, EGFR and HER2 gene signals were significantly higher in follicular ameloblastomas than in plexiform ameloblastomas. Direct DNA sequencing of EGFR did not show any gene alteration in ameloblastomas.Expression of HER family molecules, especially EGFR and HER4, in odontogenic tissues suggests that growth signals mediated by these receptor molecules contribute to cell proliferation, survival, and differentiation in both normal and neoplastic odontogenic epithelial tissues. Some of these molecules might be useful for predicting outcomes in patients with ameloblastomas.

CISH

10.1111/jop.12024

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What Does Politics Bring to Okinawa?

Japanese Sociological Review (2016)

Hiroyuki Kumamoto

本稿の目的は, 普天間基地移設問題を事例に, 米軍基地をめぐる政治が沖縄に何をもたらしてきたのか明らかにすることである. 補完性原理を理念的背景にもつ地方自治法第1条の2が定めている国家存立事務には, 外交や防衛が含まれている. それを根拠に, 政府は, 沖縄県の強い反対があるにもかかわらず, 名護市辺野古区への普天間代替施設の建設を進めている.

10.4057/jsr.67.432

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