Brigitte Renoux

Institut de Chimie des Milieux et des Matériaux de Poitiers

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Sébastien Papot

Institut de Chimie des Milieux et des Matériaux de Poitiers

Jean‐Pierre Gesson

Université de Poitiers

Jonathan Clarhaut

Université de Poitiers

Thibaut Legigan

Sorbonne Université

Isabelle Tranoy‐Opalinski

Université de Poitiers

Pauline Poinot

Institut de Chimie des Milieux et des Matériaux de Poitiers

Elodie Péraudeau

Institut de Chimie des Milieux et des Matériaux de Poitiers

Ulrich Cortes

Centre Hospitalier Universitaire de Poitiers

Anaïs Balbous

Université de Poitiers

Michel Wager

Centre Hospitalier Universitaire Amiens-Picardie

Cooperative Institutions

Centre National de la Recherche Scientifique

147

Université de Poitiers

Inserm

Institut de Chimie des Milieux et des Matériaux de Poitiers

Université Paris Cité

Centre Hospitalier Universitaire de Poitiers

Institut Curie

Université de Strasbourg

Université Paris-Saclay

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

A New Synthesis of Trifluorinated Compounds via 1,1-Dichloro-1-alkenes in Superacid.

ChemInform (2007)

Anne-Céline Cantet Jean‐Pierre Gesson Brigitte Renoux Marie‐Paule Jouannetaud

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Superacid

10.1002/chin.200745040

Cite

Citations (0)

ChemInform Abstract: Synthesis of the THF Moiety of Annonacin Based on Aldolization and Baeyer‐Villiger Oxidation.

ChemInform (1997)

Jean‐Pierre Gesson Brigitte Renoux Els Schulten

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Moiety

10.1002/chin.199746245

Cite

Citations (0)

Inside Cover: A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier (ChemMedChem 12/2011)

ChemMedChem (2011)

Marion Grinda Jonathan Clarhaut Isabelle Tranoy‐Opalinski Brigitte Renoux Arnaud Monvoisin

The inside cover picture shows a nontoxic targeting system programmed for the selective delivery of three different cytotoxic agents to the tumor site. This system includes a chemical amplifier that transforms a single tumor-associated enzymatic triggering event into the release of a highly toxic drug cocktail. For more details, see the Communication by Sébastien Papot et al. on p. 2137 ff.

Glucuronide

10.1002/cmdc.201190053

Cite

Citations (0)

Enzyme‐Cleavable Linkers for Protein Chemical Synthesis through Solid‐Phase Ligations

Angewandte Chemie International Edition (2021)

Skander Abboud Mehdi Amoura Jean‐Baptiste Madinier Brigitte Renoux Sébastien Papot

The total synthesis of long proteins requires the assembly of multiple fragments through successive ligations. The need for intermediate purification steps is a strong limitation, particularly in terms of overall yield. One solution to this problem would be solid-supported chemical ligation (SPCL), for which a first peptide segment must be immobilized on a SPCL-compatible solid support through a linker that can be cleaved under very mild conditions to release the assembled protein. The cleavage of SPCL linkers has previously required chemical conditions sometimes incompatible with sensitive protein targets. Herein, we describe an alternative enzymatic approach to trigger cleavage under extremely mild and selective conditions. Optimization of the linker structure and use of a small enzyme able to diffuse into the solid support were key to the success of the strategy. We demonstrated its utility by the assembly of three peptide segments on the basis of native chemical ligation to afford a 15 kDa polypeptide.

Linker

Native chemical ligation

Cleavage (geology)

Chemical Ligation

Solid-Phase Synthesis

Peptide Synthesis

Chemical modification

10.1002/anie.202103768

Cite

Citations (9)

Data Supplement from Selective Release of a Cyclopamine Glucuronide Prodrug toward Stem-like Cancer Cell Inhibition in Glioblastoma

Anaïs Balbous Brigitte Renoux Ulrich Cortes Serge Milin Karline Guilloteau

Supplementary Figure 3: CGP-2 decreased nestin mRNA expression.

Cyclopamine

Glucuronide

10.1158/1535-7163.22502278

Cite

Citations (0)

beta-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: An update

HAL (Le Centre pour la Communication Scientifique Directe) (2014)

Isabelle Tranoy‐Opalinski Thibaut Legigan Romain Barat Jonathan Clarhaut Mikaël Thomas

Beta-glucuronidase

Cancer Chemotherapy

BETA (programming language)

10.1016/j.ejmech2013.12.045

Cite

Citations (1)

Data from Selective Release of a Cyclopamine Glucuronide Prodrug toward Stem-like Cancer Cell Inhibition in Glioblastoma

Anaïs Balbous Brigitte Renoux Ulrich Cortes Serge Milin Karline Guilloteau

<div>AbstractRecent data suggest that inhibition of the Hedgehog pathway could be a therapeutic target for glioblastoma. Alkaloid cyclopamine inhibits Hedgehog signaling, depleting stem-like cancer cells derived from glioblastoma. However, this compound is toxic for somatic stem cells, preventing its use for clinical applications. In this study, we tested a derivatization product of cyclopamine in the form of cyclopamine glucuronide prodrug (CGP-2). This compound was used in vitro and in vivo toward glioblastoma-initiating cells (GIC). Results obtained in vitro indicate that CGP-2 is active only in the presence of β-glucuronidase, an enzyme detected in high levels in necrotic areas of glioblastomas. CGP-2 decreased proliferation and inhibited the self-renewal of all GIC lines tested. Hedgehog pathway blockade by 10 μmol/L of CGP-2 induced a 99% inhibition of clonogenicity on GICs, similar to cyclopamine treatment. Combination of CGP-2 with radiation decreased clonogenic survival in all GIC lines compared with CGP-2 alone. In a subcutaneous glioblastoma xenograft model, a two-week CGP-2 treatment prevented tumor growth with 75% inhibition at 8 weeks, and this inhibition was still significant after 14 weeks. Unlike cyclopamine, CGP-2 had no detectable toxic effects in intestinal crypts. Our study suggests that inhibition of the Hedgehog pathway with CGP-2 is more effective than conventional temozolomide adjuvant, with much lower concentrations, and seems to be an effective therapeutic strategy for targeting GICs. Mol Cancer Ther; 13(9); 2159–69. ©2014 AACR.</div>

Cyclopamine

Glucuronide

10.1158/1535-7163.c.6537043

Cite

Citations (0)

Dietary docosahexaenoic acid proposed to sensitize breast tumors to locally delivered drug

Clinical Lipidology (2010)

Stéphan Chevalier Caroline Goupille Karine Mahéo Isabelle Domingo Charles Dussiau

The important factor determining breast cancer outcome is tumor cell sensitivity to cytotoxic agents. Most anticancer drugs lack intrinsic anti-tumor selectivity, provoking adverse effects in healthy nontumor tissues. As a result, drugs cannot always be delivered to the tumor at doses sufficient to induce tumor shrinkage, increasing the risk of the development of cellular drug resistance by tumor cells. Two main approaches are currently being investigated to reduce the toxicity in nontumor tissue by using a prodrug locally delivered through biochemical activation in the tumor environment, and for specifically increasing the sensitivity of tumors to anticancer drugs by modifying the tumor tissue through dietary supplementation. Both approaches have their own limitations that would be alleviated by combining them in order to better treat breast cancers. Specifically, the potential benefit of bringing together a glucuronide prodrug with dietary supplementation using polyunsaturated fatty acids, and in particular the docosahexaenoic acid (22:6n-3), is discussed. This article also addresses the effects of the interaction of docosahexaenoic acid and breast cancer in terms of clinical outcome and mechanistic features.

10.2217/clp.10.12

Cite

Citations (5)

Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid

Journal of Controlled Release (2017)

Elodie Péraudeau Laurent Cronier Arnaud Monvoisin Pauline Poinot Coralie Mergault

Folate receptor

Valproic Acid

Combination therapy

10.1016/j.jconrel.2017.11.011

Cite

Citations (16)