Findings from cross-sectional studies on the association between coffee consumption and odds of obesity are inconsistent. We aimed to perform a meta-analysis of earlier cross-sectional studies on the association between coffee consumption and odds of obesity. The online databases of PubMed, ISI Web of Science, Scopus, Science Direct, and EMBASE were systematically searched to identify relevant publications up to April 2023. Cross-sectional studies that considered coffee as the exposure and general and abdominal obesity as the outcome were included. Studies that had reported odds ratios (ORs) as effect size were included in the meta-analysis. To pool data, a random-effects model was used. In total, 23 studies were included in our systematic review. Twelve publications on general obesity and 15 publications on abdominal obesity were examined in the meta-analysis. Overall, 207551 individuals aged ≥19 years were included. With regards to general obesity, pooling 13 effect sizes from 12 cross-sectional studies showed that coffee intake was not associated with odds of general obesity (overall OR: 1.11; 95% CI: 0.92, 1.33). In subgroup analysis by gender, we found a significant positive association between coffee consumption and odds of general obesity in women (OR: 1.84; 95% CI: 1.51, 2.24). Concerning abdominal obesity, combining 18 effect sizes from 15 studies, we failed to find a significant association between coffee consumption and odds of abdominal obesity (OR: 1.03; 95% CI: 0.92, 1.15). No significant association was found between coffee intake and odds of obesity. However, gender-stratified analyses revealed significant relationships.
It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. This study was planned to determine the effects of green cardamom on blood glucose, lipids and oxidative stress status in type 2 diabetic patients.
Background To the best of our knowledge, no previous study has reported findings on the effects of low-carbohydrate diet (LCD) on adiponectin concentration.Objective The current systematic review and dose-response meta-analysis was carried out to systematically review the available controlled clinical trials about the effect of LCD on adiponectin level in adults.Methods Literature searches of PubMed/Medline, Scopus and Web of Sciences were conducted up to August 2019. Randomized controlled trials (RCTs) which assessed the effect of LCD on the adiponectin level were selected.Results Eleven studies, including 1047 participants (LCD = 534 and control = 513), were included in the meta-analysis. Proportion of carbohydrate from calorie was from 4 to 34%. Time of the follow-up varied between studies and ranged from 6 to 152 weeks. LCD intake mildly but significantly increased adiponectin (0.02 µg/ml, 95% CI: 0.01 to 0.03, P < 0.001). Dose-response analysis indicated a nonlinear association between the percentage of carbohydrate and change in adiponectin level from baseline (P = 0.04). After subgroup analysis based on the proportion of carbohydrate from calorie, there was a significant increase in adiponectin concentration in studies that prescribed <30% of calorie from carbohydrates (0.12 µg/ml, 95% CI: 0.07–0.18). In contrast, diets which consisted ≥30% of carbohydrates had no significant effect on adiponectin (0.50 µg/ml, 95% CI: −0.46 to 1.48). Also, meta-regression analysis revealed that age (β = 0.04, P = 0.15), baseline BMI (β= −0.15, P = 0.15), time of follow-up (β = 0.01, P = 0.17), percentage of carbohydrates (β = 0.004, P = 0.90), percentage of protein (β= −0.12, P = 0.08), percentage of fat (β = 0.20, P = 0.61) and baseline adiponectin (β = 0.001, P = 0.97) are not sources of heterogeneity.Conclusion This systematic review and meta-analysis demonstrated a mild but significant effect of LCD on adiponectin concentration compared to control groups.
Abstract Objective: Previous studies on the association between glycaemic index (GI) and glycaemic load (GL) in relation to breast cancer risk are contradictory. The aim of this study was to examine the association between dietary GI and GL and risk of breast cancer in Iranian women. Design: Population-based case–control study. Dietary GI and GL were assessed using a validated Willett-format 106-item semi-quantitative FFQ. Setting: Isfahan, Iran. Participants: Cases were 350 patients with newly diagnosed stage I–IV breast cancer, for whom the status of breast cancer was confirmed by physical examination and mammography. Controls were 700 age-matched apparently healthy individuals who were randomly selected from general population. Results: After controlling for potential confounders, individuals in the highest tertile of dietary GI had 47 % higher odds of breast cancer than women in the lowest tertile (OR: 1·47; (95 % CI 1·02, 2·12)). Stratified analysis by menopausal status showed such association among postmenopausal women (OR: 1·51; (95 % CI 1·02, 2·23)). We found no significant association between dietary GL and odds of breast cancer either before (OR: 1·35; (95 % CI 0·99, 1·84)) or after adjustment for potential confounders (OR: 1·24; (95 % CI 0·86, 1·79)). In addition, stratified analysis by menopausal status revealed no significant association between dietary GL and odds of breast cancer. Conclusions: Our findings showed a significant positive association between dietary GI and odds of breast cancer. However, we observed no significant association between dietary GL and odds of breast cancer.
Abstract This systematic review and meta-analysis was done to review earlier publications on the association between dietary acrylamide intake and risk of breast, endometrial and ovarian cancers. We performed a systematic search in the online databases of PubMed, ISI Web of Science and Scopus for relevant publications up to August 2020. Prospective cohort studies that considered dietary acrylamide as the exposure variable and breast, endometrial or ovarian cancer as the main outcome variable or as one of the outcome variables were included in this systematic review and meta-analysis. A total of fourteen cohort studies were included in the meta-analysis. We found no significant association between dietary acrylamide intake and the risk of breast (relative risk (RR) 0·95; 95 % CI 0·90, 1·01), endometrial (RR 1·03; 95 % CI 0·89, 1·19) and ovarian cancers (RR 1·02; 95 % CI 0·84, 1·24). In addition, we observed no significant association between dietary acrylamide intake and the risk of breast, endometrial and ovarian cancers in different subgroup analyses by smoking status, menopausal status, BMI status and different types of breast cancer. In conclusion, no significant association was found between dietary acrylamide intake and the risk of breast, endometrial and ovarian cancers.
Purpose/introduction: There is no study on the association of empirically derived food-based dietary inflammatory index (FDII) and risk of psychological disorders. We investigated the association between FDII and odds of psychological disorders in Iranian adults.Methods and materials: In this cross-sectional study, data on dietary intakes of 3363 Iranian adult participants were collected using a validated dish-based 106-item semi-quantitative food frequency questionnaire. FDII score was constructed based on participants' dietary intakes of 28 pre-defined food groups. The Iranian validated version of Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (GHQ) was used to assess psychological disorders. Depression, anxiety and psychological distress were defined based on standard criteria.Results: After controlling for potential confounders, participants in the top quintile of FDII score had a greater odds of depression (OR: 1.49; 95% CI: 1.08–2.06), anxiety (OR: 1.92; 95% CI: 1.24–2.96), and psychological distress (OR: 1.55; 95% CI: 1.10–2.19) compared with those in the bottom quintile. When we did the analyses stratified by gender, we found a significant positive association between FDII score and depression (OR: 1.57; 95% CI: 1.04–2.35), anxiety (OR: 1.99; 95% CI: 1.19–3.34), and psychological distress (OR: 1.68; 95% CI: 1.10–2.56) among women comparing the highest and the lowest quintiles. We found no significant association between FDII score and psychological disorders in men.Conclusion: We found that greater FDII score was positively associated with psychological disorders. In the gender-stratified analysis, this was seen in women but not in men.
Studies on the association between coffee consumption and risk of lung cancer have been conflicting. The aim of this study was to systematically review the current evidence on the association between coffee consumption and risk of lung cancer and to quantify this association by performing a meta-analysis. A comprehensive systematic search was performed on online databases up to July 2023 investigating the association between coffee consumption and risk of lung cancer. All prospective cohort studies reporting odds ratios (ORs), rate or risk ratios (RRs), or hazard ratios (HRs) and 95% confidence intervals (CIs) in this context were included. The overall effect size was calculated using the random-effects model and statistical between-studies heterogeneity was examined using Cochrane's Q test and I
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