Xiaodan Zhai

Huazhong University of Science and Technology

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Lixia Xiao

Huazhong University of Science and Technology

Le Zhang

Huazhong University of Science and Technology

Pei Xiao

University of Surrey

Weiping Teng

China Medical University

Zhongyan Shan

First Hospital of China Medical University

Guanghua Liu

Huazhong University of Science and Technology

Tao Jiang

Huazhong University of Science and Technology

Cong Liu

Second Xiangya Hospital of Central South University

Yongze Li

Institute of Biophysics

Lulu Chen

Huazhong University of Science and Technology

Cooperative Institutions

China Medical University

Huazhong University of Science and Technology

First Hospital of China Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Fourth Affiliated Hospital of China Medical University

Chinese Academy of Sciences

Wuhan National Laboratory for Optoelectronics

Peking University

University of Surrey

Central South University

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Reference Intervals for Serum Thyroid-Stimulating Hormone Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis

Frontiers in Endocrinology (2021)

Xichang Wang Yongze Li Xiaodan Zhai Haoyu Wang Fan Zhang

Objective The aim of our study was to compare the reference intervals (RIs) [median (2.5 th -97.5 th percentiles)] for thyroid-stimulating hormone (TSH) between subgroups stratified by ethnicity and iodine status in a global context. Design and Methods Primary data were derived from a recently published cross-sectional study in mainland China. Secondary data were obtained from online databases. The RIs for TSH were calculated in the reference population according to the National Academy of Clinical Biochemistry (NACB) standard and in the disease-free population. A meta-analysis of ethnicity- and iodine status-specific TSH RIs was performed. Results The primary data showed that the TSH RI (mU/L) in the disease-free population was 2.33 (0.67, 7.87), which is wider than the published RI [2.28 (0.74, 7.04)] in the reference population. The meta-analysis showed that whether in the reference or disease-free population, the RIs in Yellows were much higher than those in Caucasians. In the reference population, the median and 2.5 th percentile in the iodine-sufficient subgroup were both lower than the iodine-deficient or more-than-adequate subgroup, while the 97.5 th percentile showed a positive trend with increasing sufficiency of iodine. However, in the disease-free population, the iodine-sufficient subgroup had a lower median and 97.5 th percentile but higher 2.5 th percentile than the iodine-deficient subgroup. Conclusion Yellows have a higher TSH RI than Caucasians. In the reference population, both the median and 2.5 th percentile TSH in the iodine-sufficient population were the lowest among the different iodine status subgroups, while the 97.5 th percentile of TSH showed an upward trend with increasing iodine sufficiency.

Thyroid-stimulating hormone

Subgroup analysis

Thyroid disease

10.3389/fendo.2021.660277

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Citations (9)

Puzzle in the diagnosis and treatment of subclinical hypothyroidism in the elderly

Zhonghua neifenmi daixie zazhi (2014)

Xiaodan Zhai

Based on laboratory tests,subclinical hypothyroidism is diagnosed and defined as an elevated serum TSH concentration with FT4 within reference range.Alterations in thyroid function are associated with aging.All available studies show that prevalence of subclinical hypothyroidism increases with aging,especially in women.However,some studies advise that serum TSH reference range for older people should be modified,because serum TSH elevates with aging.Therefore,when to and how to treat subclinical hypothyroidism in the elderly has been debating fiercely.At present,levothyroxine sodium treatment is generally recommended when TSH is raised more than 10 mIU/L.When TSH level is between the upper limit of the reference range and 10 mIU/L,treatment should depend on symptoms,history and risk factors of cardiovascular disease.Therapeutic objective should be individualized,depending on age,cardiac function,and other conditions. Key words: Elderly; Subclinical hypothyroidism ; Diagnosis ; Treatment

Subclinical infection

Levothyroxine

Reference range

Elderly people

10.3760/cma.j.issn.1000-6699.2014.12.022

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Citations (1)