Chaowei Song

Jimei University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Wanbo Li

Ministry of Agriculture and Rural Affairs

Zhiyong Wang

Qingdao National Laboratory for Marine Science and Technology

Fang Han

Nanchang University

Zhiyong Wang

Jimei University

Zhiyong Wang

Carnegie Department of Plant Biology

Fang Han

Chinese People's Liberation Army

Zhenye Zhao

Jimei University

Yao Yang

Shanghai Ocean University

Ying Huang

Chinese Academy of Medical Sciences & Peking Union Medical College

Ying Huang

Jimei University

Cooperative Institutions

Jimei University

Ministry of Agriculture and Rural Affairs

Qingdao National Laboratory for Marine Science and Technology

Sun Yat-sen University

Henan Academy of Agricultural Sciences

Zhengzhou University

Hainan University

Kunming Medical University

Chinese Academy of Sciences

Harbin Institute of Technology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

The Landscape of Liver Chromatin Accessibility and Conserved Non-coding Elements in Larimichthys crocea, Nibea albiflora, and Lateolabrax maculatus

Marine Biotechnology (2022)

Chaowei Song Wanbo Li Zhiyong Wang

Lateolabrax

10.1007/s10126-022-10142-y

Cite

Citations (0)

The investigation of sex‐differential open chromatin in liver, spleen and gonads in Larimichthys crocea through ATAC ‐seq

Aquaculture Research (2022)

Chaowei Song Zhiyong Wang Wanbo Li

Sex dimorphism is a fascinating science problem, which includes phenotypic, transcriptomic and epigenetic differences in male and female. To explore the landscape of transcriptome and its regulation in different sex in the large yellow croaker (Larimichthys crocea), we investigated the open chromatin using ATAC-seq generated from livers, spleens and gonads in males and females. First, we found a male-specific open chromatin region upstream of the dax1 gene, which contained Nr2e1 binding footprint. Second, the motif of Nfy was significantly enriched in the open chromatins of male spleen, liver and testis using Homer. Third, the motifs of RA signal transduction and Nr2f6 were in the female-specific transcription factor footprints, which were only in ovary of the large yellow croaker, but not in the liver and spleen of female. Finally, we found a subset of super enhancers that drove the identity genes of specific cells within the testes and ovaries. In this study, the sex difference of fish was discussed from the perspective of open chromatin regions to fill the gap in this field.

10.1111/are.15882

Cite

Citations (1)

Epigenetic Analysis of Chromatin Accessibility and Immune Gene Expression Regulation in Large Yellow Croaker (Larimichthys Crocea) Following Iridovirus Infection

Fang Han Chaowei Song Ying Huang Zhiyong Wang

Iridovirus

10.2139/ssrn.4883740

Cite

Citations (0)

Transcriptomics and Proteomics Analysis Reveals Damage to the Intestine and Gill Of  <i>Larimichthys Crocea</i> Exposed to Iridovirus

Ying Huang Wanbo Li Zhenye Zhao Yao Yang Chaowei Song

The large yellow croaker (Larimichthys crocea) is an economically important marine aquaculture fish in China. Diseases caused by iridovirus infection have led to severe economic losses in the aquaculture of large yellow croaker, restricting the healthy development of the aquaculture industry. Studying the immune response activated by fish against pathogens can provide new insights into disease prevention and control. This study focuses on the large yellow croaker, analyzing the comprehensive response of mucosal immune-related organs (intestine and gills) under iridovirus infection from the perspectives of tissue pathology, transcriptome, and proteome. A comprehensive analysis of multi-omics data and histopathological results was conducted to study the changes in fish infected with iridovirus at the molecular, cellular, and organ levels. This study aims to select important genes related to the immune mechanism of large yellow croaker against iridovirus and elucidate the molecular regulatory mechanisms of fish mucosal immunity, providing a scientific basis for the prevention and control of fish diseases.

Iridovirus

10.2139/ssrn.4730364

Cite

Citations (0)

Chromatin accessibility and differentially expressed genes profiling in large yellow croaker (Larimichthys crocea) head kidney cells following iridovirus infection

Frontiers in Immunology (2025)

Chaowei Song Ying Huang Fang Han Zhiyong Wang

Introduction The large yellow croaker iridovirus (LYCIV) poses a significant threat to the aquaculture industry of Larimichthys crocea . Understanding the host defense response to LYCIV infection is crucial for developing effective strategies to mitigate its impact. Methods In this study, an epigenetic approach was employed to investigate dynamic changes in chromatin accessibility using the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). Additionally, RNA sequencing (RNA-seq) was used to analyze the expression pattern of immune response genes upon LYCIV infection. Results Substantial alterations in chromatin accessibility were observed, particularly in the regulatory regions of key immune-related genes. Significant changes in the expression of AP-1 transcription factors, including the Batf gene, were noted. CUT&Tag results revealed that AP-1 was significantly enriched in the open chromatin regions of cytokine genes, with Batf potentially regulating the cytokine genes LIF and CLCF1 . Discussion These findings suggest that AP-1 may play a crucial role in the defense response against viral infection by modulating inflammatory cytokines and contributing to cellular inflammatory responses. This study provides a comprehensive analysis of the epigenomic landscape and gene expression regulation during iridovirus infection in L. crocea , offering valuable insights for breeding programs aimed at combating iridovirus infections.

Epigenomics

10.3389/fimmu.2025.1513966

Cite

Citations (0)