Natalie Oxford

AndroScience (United States)

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Qiulong Huang

AndroScience (United States)

Margaret Just

AndroScience (United States)

Cherlyn Miranda

AndroScience (United States)

Shourong Li

Anhui Jianzhu University

Oscar Baterina

AndroScience (United States)

Castle Funatake

Thermo Fisher Scientific (Israel)

Ana V. Miletic

University of Zagreb

Dariusz Stepniak

Arena Pharmaceuticals (United States)

Nicolas Schrantz

R&D Systems (United States)

Brandi Atteberry

Volition (United States)

Cooperative Institutions

AndroScience (United States)

Thermo Fisher Scientific (Israel)

Thermo Fisher Scientific (United States)

Texas A&M University

Raytheon Technologies (Finland)

Abbott (United Kingdom)

Discovery Laboratories (United States)

Abbott (United States)

Anhui Jianzhu University

Beijing University of Chemical Technology

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Novel anti-Mer antibodies in macrophage phenotype analysis (INC2P.419)

The Journal of Immunology (2015)

Dariusz Stepniak Brandi Atteberry Shourong Li Oscar Baterina Natalie Oxford

Abstract Mer is a member of the TAM family of tyrosine kinase receptors that also includes Axl and Tyro3. Mer is expressed on a subset of anti-inflammatory macrophages and is involved in the removal of apoptotic cells. The engulfment of apoptotic cells relies on two soluble accessory molecules Protein S and Gas6 that bind to phosphatidylserine, which is found on the outer leaflet of the plasma membrane of cells undergoing apoptosis. Upon binding these ligands, Mer undergoes autophosphorylation at multiple tyrosine residues that activate the PI3K and Akt pathways. This then leads to the phagocytosis and clearance of apoptotic cells and also results in the direct inhibition of TLR-induced production of pro-inflammatory cytokines. Deficiency of Mer causes general autoimmunity, inflammation, and accumulation of apoptotic bodies. Because Mer expression strongly correlates with macrophage function, It can be used for phenotyping macrophage subpopulations. Here we use novel anti-Mer antibodies in flow cytometric analysis of macrophages and corroborate the expression of this receptor and its importance in distinguishing functional macrophage subsets.

GAS6

MERTK

10.4049/jimmunol.194.supp.55.13

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