Amy E. Sparks

University of Toledo

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Bradley J. Van Voorhis

University of Iowa

116

Karen M. Summers

University of Iowa Health Care

Craig H. Syrop

University of Iowa

E. Hakan Duran

University of Iowa Health Care

Ginny L. Ryan

University of Washington

J. Bruce Redmon

University of Minnesota

Anuja Dokras

Hospital of the University of Pennsylvania

Shanna H. Swan

Hofstra University

Jay Sandlow

Medical College of Wisconsin

Patrick Ten Eyck

University of Iowa

Cooperative Institutions

Cornell University

240

University of Córdoba

222

University of Iowa

127

University of Iowa Hospitals and Clinics

Inserm

Harvard University

National Institutes of Health

University of North Carolina at Chapel Hill

Johns Hopkins University

Centro Medicina della Riproduzione

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Exposure to prenatal life events stress is associated with masculinized play behavior in girls

NeuroToxicology (2014)

Emily S. Barrett J. Bruce Redmon Christina Wang Amy E. Sparks Shanna H. Swan

Prenatal Stress

Perceived Stress Scale

Association (psychology)

10.1016/j.neuro.2013.12.011

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Citations (36)

Prenatal Intravenous Magnesium at 30-34 Weeks’ Gestation and Neurodevelopmental Outcomes in Offspring

JAMA (2023)

Caroline A Crowther Pat Ashwood Philippa Middleton Andrew J. McPhee Thach Tran

Importance Intravenous magnesium sulfate administered to pregnant individuals before birth at less than 30 weeks’ gestation reduces the risk of death and cerebral palsy in their children. The effects at later gestational ages are unclear. Objective To determine whether administration of magnesium sulfate at 30 to 34 weeks’ gestation reduces death or cerebral palsy at 2 years. Design, Setting, and Participants This randomized clinical trial enrolled pregnant individuals expected to deliver at 30 to 34 weeks’ gestation and was conducted at 24 Australian and New Zealand hospitals between January 2012 and April 2018. Intervention Intravenous magnesium sulfate (4 g) was compared with placebo. Main Outcomes and Measures The primary outcome was death (stillbirth, death of a live-born infant before hospital discharge, or death after hospital discharge before 2 years’ corrected age) or cerebral palsy (loss of motor function and abnormalities of muscle tone and power assessed by a pediatrician) at 2 years’ corrected age. There were 36 secondary outcomes that assessed the health of the pregnant individual, infant, and child. Results Of the 1433 pregnant individuals enrolled (mean age, 30.6 [SD, 6.6] years; 46 [3.2%] self-identified as Aboriginal or Torres Strait Islander, 237 [16.5%] as Asian, 82 [5.7%] as Māori, 61 [4.3%] as Pacific, and 966 [67.4%] as White) and their 1679 infants, 1365 (81%) offspring (691 in the magnesium group and 674 in the placebo group) were included in the primary outcome analysis. Death or cerebral palsy at 2 years’ corrected age was not significantly different between the magnesium and placebo groups (3.3% [23 of 691 children] vs 2.7% [18 of 674 children], respectively; risk difference, 0.61% [95% CI, −1.27% to 2.50%]; adjusted relative risk [RR], 1.19 [95% CI, 0.65 to 2.18]). Components of the primary outcome did not differ between groups. Neonates in the magnesium group were less likely to have respiratory distress syndrome vs the placebo group (34% [294 of 858] vs 41% [334 of 821], respectively; adjusted RR, 0.85 [95% CI, 0.76 to 0.95]) and chronic lung disease (5.6% [48 of 858] vs 8.2% [67 of 821]; adjusted RR, 0.69 [95% CI, 0.48 to 0.99]) during the birth hospitalization. No serious adverse events occurred; however, adverse events were more likely in pregnant individuals who received magnesium vs placebo (77% [531 of 690] vs 20% [136 of 667], respectively; adjusted RR, 3.76 [95% CI, 3.22 to 4.39]). Fewer pregnant individuals in the magnesium group had a cesarean delivery vs the placebo group (56% [406 of 729] vs 61% [427 of 704], respectively; adjusted RR, 0.91 [95% CI, 0.84 to 0.99]), although more in the magnesium group had a major postpartum hemorrhage (3.4% [25 of 729] vs 1.7% [12 of 704] in the placebo group; adjusted RR, 1.98 [95% CI, 1.01 to 3.91]). Conclusions and Relevance Administration of intravenous magnesium sulfate prior to preterm birth at 30 to 34 weeks’ gestation did not improve child survival free of cerebral palsy at 2 years, although the study had limited power to detect small between-group differences. Trial Registration anzctr.org.au Identifier: ACTRN12611000491965

10.1001/jama.2023.12357

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Citations (17)

EDUCATING PATIENTS ABOUT PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY(PGT-A) -A PILOT STUDY

Fertility and Sterility (2024)

Prapti Singh Karen M. Summers Alithea Zorn Nour Chanouha Renata Thoeny

10.1016/j.fertnstert.2024.05.117

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The effects of smoking on ovarian function and fertility during assisted reproduction cycles

Obstetrics and Gynecology (1996)

Bradley J. Van Voorhis Jeffrey D. Dawson Dale W. Stovall Amy E. Sparks Craig H. Syrop

To investigate the effects of cigarette smoking on ovarian function and fertility in women undergoing assisted reproduction cycles.We assessed the effects of smoking on ovarian function and fertility in a cohort of 499 women. Questionnaires were designed to quantify past smoking exposure and to determine whether the woman was smoking during the treatment cycle. Ovarian function characteristics and pregnancy rates were compared among current smokers, past smokers, and nonsmokers.Compared with nonsmokers, both current and past smokers have reduced gonadotropin-stimulated ovarian function. A history of increasing tobacco exposure was associated with decreasing serum estradiol concentrations, numbers of retrieved oocytes, and numbers of embryos. On average, for every 10 pack-years of cigarette smoking, 2.5 fewer mature oocytes and 2.0 fewer embryos were obtained. Women who smoked during their treatment cycle had approximately a 50% reduction in implantation rate and ongoing pregnancy rate compared with women who had never smoked. Women who quit smoking before their treatment cycle had the same pregnancy rate as nonsmokers.Cigarette smoking is associated with a prolonged and dose-dependent adverse effect on ovarian function. Smoking appears to have a more transient toxic effect on fertility, because current smokers, but not past smokers, had a markedly reduced pregnancy rate after treatment cycles compared with nonsmokers. Women should quit smoking before assisted reproduction cycles.

10.1016/0029-7844(96)00286-4

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Citations (141)

Differentially expressed genes in preimplantation human embryos: potential candidate genes for blastocyst formation and implantation

Journal of Assisted Reproduction and Genetics (2016)

Erika Munch Amy E. Sparks Jesús González Bosquet Lane K. Christenson Eric J. Devor

The aim of this study was to determine which genes and gene pathways are differentially expressed when comparing human blastocysts with cleavage-stage embryos.We individually assessed gene expression in preimplantation human embryos at cleavage (n = 3) and blastocyst (n = 3) stages. Gene expression patterns were then validated in publically available datasets and then independently validated in vitro with additional human embryos using TaqMan gene expression assays. Immunolocalization studies were conducted to identify protein expression in intact blastocyst-stage embryos.Compared to cleavage-stage embryos, blastocyst-stage embryos differentially expressed 51 genes (p < 0.001), with overrepresentation in amoebiasis pathways and pathways in cancer. Of these 51 genes, 21 were found to be independently validated in a separate, publically available dataset, with a substantial agreement with our initial findings (κ = 0.8). In an independent set of cleavage- and blastocyst-stage embryos, we validated that six of eight tested genes were differentially expressed (p < 0.05) by RT-qPCR. Immunofluorescence studies documented the presence of two studied proteins in the trophectoderm of blastocyst-stage embryos.Differentially expressed genes may be implicated in the invasion and proliferation of the early embryo. Our research highlights specific genes that may be further studied for their role in the implantation process and additionally raises questions about localized gene and/or protein expression in the trophectoderm, which could affect protocols for, and interpretation of, trophectoderm biopsies performed in in vitro fertilization cycles.

Blastomere

10.1007/s10815-016-0745-x

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Citations (16)

Semen quality at cryobanking before oncologic treatment

Yasuyo Matsumoto Lévai Írisz Sakae Goto Hidehisa HASHIMOTO S. Kokeguchi

Source

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An Evaluation of the Effect of Anesthetic Technique on Reproductive Success After Laparoscopic Pronuclear Stage Transfer

Survey of Anesthesiology (1995)

R. D. VINCENT Craig H. Syrop Bradley J. Van Voorhis D.H. Chestnut Amy E. Sparks

VINCENT JR, R. D.; SYROP, C. H.; VAN VOORHIS, B. J.; CHESTNUT, D. H.; SPARKS, A. E. T.; MCGRATH, J. M.; CHOI, W. W.; BATES, J. N.; PENNING, D. H.Author Information

BATES

10.1097/00132586-199512000-00010

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A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates

Fertility and Sterility (2007)

Ginny L. Ryan Amy E. Sparks C. Sipe Craig H. Syrop Anuja Dokras

Blastocyst Transfer

Single Embryo Transfer

10.1016/j.fertnstert.2007.03.001

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Citations (126)