Justyna Morylowska-Topolska

Medical University of Lublin

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Hanna Karakuła‐Juchnowicz

Medical University of Lublin

Paweł Krukow

Medical University of Lublin

Marta Makara‐Studzińska

Vincent Pol University

Marta Flis

Gdansk University of Physical Education and Sport

Dariusz Juchnowicz

Medical University of Lublin

Anna Urbańska

Pomeranian Medical University

Kamil Jonak

Lublin University of Technology

Karol Wróblewski

Rzeszów University

Michał Próchnicki

Medical University of Lublin

Joanna Róg

Warsaw University of Life Sciences

Cooperative Institutions

Medical University of Lublin

Instytut Medycyny Wsi im. Witolda Chodźki

Medical University of Warsaw

Medical University of Silesia

Maria Curie-Skłodowska University

Institute of Psychiatry and Neurology

Medical University of Lodz

Nicolaus Copernicus University

Charité - Universitätsmedizin Berlin

Polskie Towarzystwo Gastroenterologii

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Determination of some psychotropic drugs in serum and saliva samples by HPLC-DAD and HPLC MS

Journal of Pharmaceutical and Biomedical Analysis (2016)

Anna Petruczynik Karol Wróblewski Małgorzata Szultka‐Młyńska Bogusław Buszewski Hanna Karakuła‐Juchnowicz

Levomepromazine

Diethylamine

Aripiprazole

10.1016/j.jpba.2016.01.004

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Citations (39)

The coexistence of pituitary macroadenoma and schizophrenia – practical therapeutic implications based on the case report and the literature review

Pharmacotherapy in Psychiatry and Neurology (2021)

Piotr Hałajko Justyna Morylowska-Topolska Ryszard Sitarz Kaja Karakuła Alicja Forma

Introduction. Antipsychotic drugs may increase serum prolactin levels. This effect is the strongest in patients treated with risperidone and amisulpride. Aim. This paper (1) presents a case report of an active pituitary macroadenoma diagnosed in a patient receiving a long-term olanzapine treatment; and (2) discusses its practical therapeutic implications based on the literature review. Case report. A 28-year-old male patient had been treated with olanzapine for paranoid schizophrenia since 2008. In December 2016, an unsuccessful attempt to discontinue the drug was made as the patient had been in remission for the past few years. The attempt ended in March 2017 with psychiatric hospitalisation. MRI of the head and a prolactin test revealed a pituitary macroadenoma. The medication was changed from olanzapine to aripiprazole, but the patient’s mental status deteriorated. Ziprasidone was initiated, which resulted in symptomatic remission. The MRI scans of the head that were made in the following months showed no tumour progression. As prolactin levels were stably high, the patient received quinagolide therapy. In addition, small doses of clozapine and psychotherapy were added to the ongoing treatment. Conclusions. The present case report shows that (1) routine imaging tests should be performed as part of the diagnostic procedure in first-episode psychosis; (2) prolactin levels should be measured both before and during therapy; and (3) early and close interdisciplinary cooperation is needed to develop common therapeutic recommendations that could be applied in difficult and non-typical clinical cases, such as the one described herein.

Amisulpride

Ziprasidone

Aripiprazole

Paranoid schizophrenia

10.33450/fpn.2020.12.001

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[The influence of sociodemografic and medical variables on severity of anxiety and depressive symptoms during particular trimesters of pregnancy].

PubMed (2014)

Justyna Morylowska-Topolska Marta Makara‐Studzińska Jan Kotarski

The aim of the study was to research the effect of selected socio-demographic and medical variables on the severity of symptoms of anxiety and depression in different trimesters of pregnancy.The study was prospective, longitudinal, the group consisted of 314 adult pregnant women. To assess the prevalence of depressive and anxiety symptoms the Hospital Anxiety and Depression Scale (HADS) was used. The results were statistically analyzed. To assess the normal distribution the Shapiro-Wilk test was used. Non-parametric tests: Mann Whitney U test and Kruskal Wallis ANOVA were used due to the distribution of the variables tested against the intergroup comparisons that deviate from the normal distribution.Only the assessment of the financial and housing situation given by the respondents was related to the severity of symptoms of anxiety and depression in the course of the entire pregnancy. The unmarried respondents had greater severity of depressive symptoms in the first and third trimesters. Other socio-demographic variables were not associated with the severity of symptoms of anxiety and depression in different trimesters of pregnancy. Medical variables (associated with an obstetric-gynecological history), such as a history of miscarriage, complications in a previous pregnancy, the mode of delivery in a previous pregnancy, generally did not affect the severity of symptoms of anxiety and depression during pregnancy. Only major symptoms of depression during the third trimester were associated with complications in a previous pregnancy. An unplanned pregnancy turned out to be one of the most crucial variables determining higher severity of anxiety and depression during pregnancy.The knowledge of socio-demographic and medical factors associated with the severity of symptoms of anxiety and depression during pregnancy may facilitate better monitoring the groups of women being particularly vulnerable to the occurrence of these disorders. The introduction of screening tests regarding anxiety and depression during pregnancy, being carried out systematically in the course of pregnancy provides an opportunity for earlier diagnosis and more rapid implementation of good practice.

Depression

Longitudinal Study

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Citations (9)

Bioelements and eating disorders - aspects of the quality of live

Journal of Elementology (2012)

Marta Makara‐Studzińska Justyna Morylowska-Topolska Anna Koślak Anna Urbańska

10.5601/jelem.2010.15.2.405-412

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An overlooked issue: sexual dysfunctions in men addicted to alcohol

Current Problems of Psychiatry (2018)

Jakub Siembida Piotr Frończuk Justyna Morylowska-Topolska Aleksandra Siek Hanna Karakuła‐Juchnowicz

Introduction According to the data obtained in the EZOP Poland study (2015), the prevalence of alcohol dependence in lifetime in Poland amounts to about 2.2% of the population, entailing enormous social, family and personal harm, including health damage. It is estimated that about 72% of alcohol-dependent patients complain about one or more problems related to the sexual sphere, which may result from both the development of somatic complications in the course of alcohol dependence, and from psychiatric complications that themselves can lead to sexual dysfunction. There are reports and clinical observations indicating that the occurrence of sexual dysfunction (SD) can affect the shortening or interruption of the period of abstinence.Aim The aim of this work is to show sexual dysfunctions in alcohol-dependent men and to discuss the factors that may affect the occurrence of the above-mentioned dysfunctions.Material and methods The available literature was reviewed using Medline, Google Scholar and ScienceDirect browsers by entering the keywords: alcohol dependence, sexual dysfunction, comorbidity, alcohol-caused diseases and time descriptors: 1979-2016.Results• Alcohol dependence is associated with the occurrence of various types of sexual dysfunctions (SD).• The diagnosis of SD should take into account all possible causes that may lead to the development of SD in

Alcohol Dependence

Affect

10.2478/cpp-2018-0010

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Citations (3)

Lęk i depresja u kobiet leczonych z powodu niepłodności

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

Marta Makara‐Studzińska Justyna Morylowska-Topolska Artur Wdowiak Grzegorz Bakalczuk Szymon Bakalczuk

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The role of oxytocin in the pathogenesis and treatment of schizophrenia

Current Problems of Psychiatry (2017)

Katarzyna Jusiak Żaneta Brudkowska Maria Gołębiowska Justyna Morylowska-Topolska Beata Gołębiowska

Abstract Introduction: Until recently, oxytocin was mainly associated with the pathophysiology of childbirth and sexual functions, but lately this hormone has become the object of interest to psychiatry and psychology due to the significant influence of oxytocin on human behavior in the field of social and emotional functioning. Current scientific research focuses on the participation of oxytocin in the pathogenesis and therapy of mental disorders. Aim: The aim of the paper is to present, on the basis of available literature, the significance of oxytocin for various psychological functions, with particular emphasis on the influence of oxytocin on the course and clinical picture of schizophrenia. Method: Available articles from the Medline / PubMed database were analyzed, which were searched using keywords: oxytocin, schizophrenia, therapeutic use of oxytocin, social cognition, positive symptoms, negative symptoms and time descriptors: 2013-2017. There are included articles published in Polish and English. Results:The research results carried out so far suggest that oxytocin plays a significant role in modulating complex socio-emotional behaviors in schizophrenic patients. The existing research results also indicate a relationship between the dysregulation of the oxytocinergic system and the pathophysiology of schizophrenia. Many of the studies prove that there is a relationship between the level of oxytocin in the patients' blood plasma and the severity of the disease symptoms. Recent genetic studies indicate a possible relationship between polymorphism of oxytocin genesand polymorphism of oxytocin receptor genes and the risk of developing schizophrenia. Conclusions: Contemporary research on the therapeutic potential of oxytocin and its influence on the functioning of schizophrenia patients seem to be very promising and may contribute to increasing the effectiveness of treatment of schizophrenia and possibly other mental disorders, which in turn will improve the quality of life of patients in cognitive, social and emotional functioning.

Oxytocin receptor

10.1515/cpp-2017-0023

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DETERMINATION OF VENLAFAXINE, VILAZODONE AND THEIR MAIN ACTIVE METABOLITES IN HUMAN SERUM BY HPLC-DAD AND HPLC-MS.

PubMed (2017)

Anna Petruczynik Karol Wróblewski Małgorzata Szultka‐Młyńska Boguslaw Buszewsk Hanna Karakuła‐Juchnowicz

A high performance liquid chromatography (HPLC) method for simultaneous analysis of venlafaxine and its major metabolite 0-desmethylvenlafaxine and vilazodone and its methabolite M10 have been devel- oped and validated. Chromatography was performed on the Phenyl-Hexyl column with mobile phase containing methanol, acetate buffer at pH 3.5 and diethylamine. The application of stationary phase with 7r-7c moieties and mobile phase containing diethylamine as silanol blocker lets to obtain double protection against silanols and thus very high theoretical plate numbers were obtained. The good separation selectivity, good peaks' symmetry and very high systems efficiency for all investigated compounds were obtained in applied chromatographic system. The method is very efficient and suitable for the analysis of investigated drugs and their metabolites in human serum for patients' pharmacotherapy control.

Diethylamine

Active metabolite

Silanol

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Citations (6)

Socio-demographical and psychosocial determinants of anxiety symptoms in a population of pregnant women in the regions of central and eastern Poland.

PubMed (2013)

Marta Makara‐Studzińska Justyna Morylowska-Topolska Katarzyna Sygit Marian Sygit Małgorzata Goździewska

Until recently, depression and anxiety during pregnancy were a neglected medical problem. The purpose of this study was to determine the prevalence of symptoms of anxiety and depression during pregnancy and identification of the socio-demographic and psychosocial factors.The study was prospective and longitudinal, and the research group consisted of 314 adult pregnant women. To assess the prevalence of anxiety symptoms and depression, the Hospital Anxiety and Depression Scale (HADS) was applied. To assess the psychosocial variables the Rosenberg Self-Assessment Scale, Marital Communication Questionnaire and the Berlin Social Support Scale and authors' Socio-demographical questionnaire were used. To assess the normal distribution the Shapiro-Wilk test was used. For non-parametric tests the Mann Whitney U test and Kruskal Wallis ANOVA were used due to the distribution of the variables tested against the intergroup comparisons that deviate from the normal distribution.Co-existence of anxiety and depression in different trimesters amounted relatively to 12.7% in the first trimester, 10.8% in the second trimester and 12.4% in the third trimester of pregnancy. Symptoms of anxiety were often experienced by unmarried women, non-working women, and those respondents who estimated their housing and financial situation as being worse. Those most susceptible to depressive symptoms were tested women with primary education and those who assessed as worse their financial and housing situation. Higher self-esteem, good communication in a relationship, satisfying social support was associated with a lower incidence of anxiety symptoms during pregnancy. Higher self-esteem, good communication in a relationship, and satisfying social support was associated with a lower incidence of anxiety symptoms during pregnancy.

Marital status

Depression

Longitudinal Study

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Citations (23)

Demand for services provided for the disabled rural inhabitants in the Lublin Region

Medycyna Ogólna i Nauki o Zdrowiu (2010)

Marta Makara‐Studzińska Justyna Morylowska-Topolska Ewa Rudnicka-Drożak

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