Differential evaluation was carried out of hypertrophy as a factor possibly of compensatory or that of furthering disturbances of the coronary circulation and contractile function of the myocardium. Echocardiography, radionuclide ventriculography tests with physical loads revealed that only moderate hypertrophy of the left ventricle in IHD patients with hypertensive disease (grade II) may be considered as one of the compensatory factors maintaining the functional state of the left ventricle myocardium.
It was established that left ventricular hypertrophy in patients with ischemic heart disease associated with hypertensive disease reflects a functionally more intact myocardium than similar hypertrophy in analogous patients without hypertensive disease. Hypertrophy of the left ventricle in patients with ischemic heart of different severity may be considered an index of myocardial lesion and this should be considered in the treatment tactics.
An analysis of the dynamics of diastolic rigidity, contractile function of the left ventricle and physical load tolerance under the effect of single intakes of phynoptin and corinfar and their course use in patients with IHD showed that they were more effective in case of increased mass of the myocardium. This indicates that increased mass of the myocardium is an additional indication to calcium antagonists in these patients.
