John C.H. Steele

Augusta University

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Joseph T. DiPiro

Virginia Commonwealth University

Dale A. Schwab

Quest Diagnostics (United States)

Andrea J. Linscott

Ochsner Medical Center

Alice S. Weissfeld

Dermatology Specialists

Donna M. Wolk

American Society for Microbiology

Lynne Shore Garcia

Creighton University

Paul Bachner

Albert B. Chandler Hospital

Michael R. Lewis

University of Missouri

Vickie S. Baselski

University of Tennessee Health Science Center

John F. Fisher

Augusta University

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Augusta University

Augusta University Health

National Institutes of Health

Georgia Regents Medical Center

Centers for Disease Control and Prevention

University of Georgia

University of Alabama at Birmingham

National Institute of Allergy and Infectious Diseases

Veterans Health Administration

United States Department of Health and Human Services

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Enzootic Abortion.

The Veterinary Journal (1900) (1901)

John C.H. Steele

Enzootic

10.1016/s0372-5545(17)72932-x

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Clinical Review : Acute Bacterial Meningitis in Childhood

Clinical Pediatrics (1972)

J. Murray Peter Fleming C.S. Anglin John C.H. Steele Michitaka Fujiwara

When acute purulent meningitis is treated as a medical emergency, the diagnosis made early and the correct medications started im mediately in the proper dosages and by the proper routes, the chances for recovery are excellent. For antibiotic therapy to be most effective, attention must also be directed to anticipating the many complicating hazards, and preventing them. Ampicillin is the antibiotic of first choice. For the child who is allergic to penicillin, chloramphenicol is recommended until the causative organism is identified. The concomitant administration of sulphonamides, streptomycin or other antibiotics is unnecessary and may be harm ful except in the neonatal period when it is recommended to commence therapy with ampicillin and gentamicin. This report outlines in detail the authors' program for the specific and supportive treatment of bacterial meningitis and the preven tion and management of its major complications. The 100 cases most recently treated at The Hospital for Sick Children, Toronto, had a case fatality rate of 2.2 per cent.

10.1177/000992287201100809

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Growth of four microorganisms in polyethylene glycol-electrolyte lavage solution

American Journal of Health-System Pharmacy (1986)

Tina S. Akly Joseph T. DiPiro John C.H. Steele George A. Kemp

The growth of Staphylococcus epidermidis, Serratia marcescens, Pseudomonas aeruginosa, and Candida albicans in reconstituted polyethylene glycol-electrolyte lavage solution (PEG-ELS) stored under refrigeration and at room temperature was studied. A standard inoculum of each organism was added to one of four 4-L containers (one organism per container). From each container 28 aliquots of 25-mL each were removed and stored under refrigeration or at room temperature. One container was not inoculated and served as a control. Duplicate aliquots of the inoculated and the control solutions were filtered and incubated for quantification of organisms on days 0, 1, 2, 4, 8, 16, and 30. Solutions stored at room temperature supported the growth of S. marcescens and Ps. aeruginosa. The counts of these organisms increased to approximately 10(6) colony-forming units (CFU)/mL over 16 days. The counts of Staph. epidermidis in solutions stored at room temperature increased slightly over the first 24 hours and declined steadily to zero after day 4. C. albicans reached a maximum colony count of 5.84 cfu/mL on day 16 and steadily declined to 0.92 cfu/mL on day 30. Solutions stored under refrigeration did not support the growth of any microorganisms. Microbial growth was not detected in any of the control solutions over the 30-day study period. The polyethylene glycol-electrolyte lavage solution studied here should be refrigerated after reconstitution to minimize microbial growth. This solution may be used for up to 30 days after reconstitution when it is stored under refrigeration.

Bacterial growth

Colony-forming unit

10.1093/ajhp/43.12.3013

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The effect of plasmin on human plasma low density lipoprotein

Thrombosis Research (1979)

John C.H. Steele

Low-density lipoprotein

10.1016/0049-3848(79)90165-8

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Citations (19)

Preface

Clinics in Laboratory Medicine (1999)

John C.H. Steele

10.1016/s0272-2712(18)30098-2

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Rational formulary selection of antimicrobials.

PubMed (1987)

Joseph T. DiPiro John C.H. Steele

Formulary

Source

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The effect of hyperlipoproteinemia on thrombolysis: In vitro studies using purified lipoproteins from normolipemic donors

Thrombosis Research (1986)

John C.H. Steele M.T. Speidel A. Bleakley Chandler

Lipoprotein(a)

10.1016/0049-3848(86)90152-0

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Community-Acquired Methicillin-Resistant Staphylococcus aureus Necrotizing Fasciitis in an Infant

Clinical Microbiology Newsletter (2008)

Chase Baldwin Samsel Reda Bassali John C.H. Steele Kristina G. Hultén Dennis L. Murray

10.1016/j.clinmicnews.2008.10.003

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Lack of influence of commonly used drugs on bioassay indicator organisms

Antimicrobial Agents and Chemotherapy (1983)

Joseph T. DiPiro A. Thomas Taylor John C.H. Steele

Many commonly used pharmaceutical agents have been found to inhibit bacterial growth in vitro. Determinations of antimicrobial concentrations in sera of patients taking nonrecognized antibacterial agents could possibly be altered if bioassay systems are utilized for the determinations. We therefore attempted to determine the in vitro effect of commonly used drugs on bioassay indicator organisms. Fifty-one different agents (antihistamines, anticholinergics, central nervous system agents, cardiovascular agents, analgesics, steroids, muscle blockers, and other miscellaneous agents) were tested for inhibition or enhancement of the growth of Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, and Klebsiella pneumoniae. None of the agents tested exhibited any effect on standard in vitro bioassay organisms. Nortriptyline hydrochloride inhibited the growth of B. subtilis and M. luteus at a concentration of 500 micrograms/ml (zones of inhibition, 14 and 13 mm, respectively), but no inhibition was observed with concentrations of 50 micrograms/ml or lower.

Micrococcus luteus

10.1128/aac.23.5.703

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Molecular weight and hydrodynamic properties of apolipoprotein B in guanidine hydrochloride and sodium dodecyl sulfate solutions.

Journal of Biological Chemistry (1979)

John C.H. Steele Julie Reynolds

The apolipoprotein B polypeptide of human serum low density lipoprotein exists (after reduction of disulfide bonds) as a random coil with a molecular weight of 250,000 in concentrated solutions of guanidine hydrochloride. With intact disulfide bonds, there is a limited restraint on the polypeptide conformation in this denaturing solvent. In the presence of saturating amounts of bound sodium dodecyl sulfate, the apolipoprotein is dimeric and highly asymmetric. This work substantiates the monomeric molecular weight of 250,000 for apolipoprotein B reported by others (Smith, R., Dawson, J.R., and Tanford, C. (1972) J. Biol. Chem. 247, 3376-3381) and demonstrates that the dimeric state of the polypeptide extant in vivo is maintained in micellar detergent solution.

Guanidine

Sodium dodecyl sulfate

Random coil

Hydrochloride

10.1016/s0021-9258(17)37820-1

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Citations (79)