Alper Kafkaslı

İstanbul Eğitim ve Araştırma Hastanesi

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Kemal Sarıca

Biruni University

ÖY

Özgür Yazıcı

Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi

CŞ

Cahit Şahin

Education Training And Research

Rahim Horuz

Istanbul Medipol University

Murat Tuncer

Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi

Mustafa Bilal Hamarat

University of Health Science

Mustafa Boz

Cleveland Clinic London

CÇ

Cihangir Çetinel

Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi

Bilal Eryıldırım

Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi

ÖC

Önder Cangüven

Hamad Medical Corporation

Cooperative Institutions

Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi

Sağlık Bilimleri Üniversitesi

İstanbul Eğitim ve Araştırma Hastanesi

Istanbul University

University of Health Science

Haseki Eğitim ve Araştırma Hastanesi

Ministry of Health

Universidad CES

University of Health Sciences

Hacettepe University

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Traumatic masturbation and erectile dysfunction: A matched case–control study

International Journal of Urology (2023)

Utku Can Alper Kafkaslı Alper Çoşkun Cengiz Çanakçı Erdinç Dinçer

To identify atypical masturbatory behaviors (AMB) and to reveal their effects on both sexual and masturbational erection hardness in men with erectile dysfunction (ED).Patients with ED and healthy controls were questioned about their masturbation habits. Accordingly, "rubbing in a prone position," "pressure on penis," and "masturbation through clothes" were included in the traumatic masturbation syndrome (TMS) group. Erection hardness score (EHS) is used to measure the erectile functions during masturbation (mast), foreplay (presex), and sexual intercourse (sex), separately.The data of 448 participants, 266 (59%) from the patient group, and 182 (41%) from the control group were analyzed. The mean ages were 30 years in both groups (p = 0.734). The rate of "rubbing in a prone position" and "penile pressure" while masturbating was higher in patients than the controls (10.2% vs. 6%, p = 0.024 and 8.6% vs. 3.3%, p = 0.0002, respectively). Patients had 2.2-fold (odds ratio, 2.21; 95% confidence interval, 1.40-3.47; p = 0.001) increased risks of having at least one AMB, compared with controls. In the secondary analysis, the patient group was divided into 2 subgroups according to having TMS (ED + TMS) or not (ED). The percentage of patients with EHS≥3 during masturbation was higher than those during sex and presex in the "ED + TMS" group (60.2%, 38.8%, and 37.2%, respectively, p = 0.0001; n = 98). Comparing the percentage of patients with EHS≥3 during mast, presex, and, sex was found to be similar in the "ED" group (58.9%, 56.5%, and 56%, respectively, p = 0.753; n = 168).Atypical masturbatory behaviors are more common in young men presenting with erectile dysfunction. These patients have higher erection hardness scores during masturbation compared to partnered sex.

Sexual intercourse

10.1111/iju.15279

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Citations (2)

Testosterone status is not associated with bladder cancer parameters in adult male patients: results of a prospective controlled study

The Aging Male (2021)

Alper Kafkaslı Özgür Yazıcı Utku Can Erdinç Dinçer Oktay Akça

This controlled study assessed whether there was a correlation between serum total testosterone levels and bladder cancer (BCa) in terms of tumor grade and stage as objective measures in adult men.Our prospectively-designed study included 257 patients who were diagnosed with primary BCa and its surgery between January 2017 and January 2020. Hundred and forty patients who had surgery in the same period with TUR for prostate or endoscopic ureteral stone treatment were included in the study as a control group. All patients in the study and control groups were male. The age range of the patients was between 34 and 90 years old. In order to examine groups, fasting blood glucose, lipid profile, albumin, total testosterone, and vitamin D levels of all patients included in the study.The relationship between tumor aggression and total testosterone level was investigated with a multinomial logistic regression model, where the control group was accepted as a reference, following adjustment for potential confounding variables, including age and serum albumin levels. Testosterone level was not found to be associated with any of the categories that determine tumor aggressiveness (p > 0.05).In the present study, there was no correlation between any categories that determine tumor aggressiveness of BCa and total testosterone levels in adult men. It is obvious that our findings should be supported and further investigations are needed.

10.1080/13685538.2020.1808968

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Relationship between serum Asymmetrical Dimethylarginine level and urolithiasis

Eastern Journal Of Medicine (2020)

Özgür Yazıcı Kadriye Aydın Şule Temizkan Fehmi Narter Akif Erbin

Asymmetric dimethylarginine

10.5505/ejm.2020.08870

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Citations (2)

E79 The role of medical therapy in the treatment of lower urinary system symptoms following ureteroscopic lithotripsy

European Urology Supplements (2013)

Bilal Eryıldırım Murat Tuncer Cahit Şahin Alper Kafkaslı Cihangir Çetinel

Medical Therapy

Ureteroscopy

10.1016/s1569-9056(13)61745-5

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Contemporary Management of Medium-Sized (10–20 mm) Renal Stones: A Retrospective Multicenter Observational Study

Journal of Endourology (2015)

Murat Can Kiremit Selçuk Güven Kemal Sarıca Ahmet Öztürk İbrahim Buldu

Purpose: To evaluate contemporary management approaches to medium-sized (10–20 mm) renal stones. Patients and Methods: A total of 935 patients treated for medium-sized renal stones (10–20 mm) between July 2012 and March 2014 were included in the study program. Contemporary minimally invasive approaches applied in the management of such stones were evaluated and compared. Results: The cohort consisted of 561 male (60%) and 374 female (40%) patients. Of the 935 patients with medium-sized renal calculi, 535 (57.2%) were treated with shockwave lithotripsy (SWL), 201 (21.4%) with retrograde intrarenal surgery (RIRS), 110 (11.7%) with minimally invasive percutaneous nephrolithotomy (miniperc), and the remaining 89 (11.7%) patients with micropercutaneous nephrolithotomy (microperc). In the SWL group, stones were located mostly in the pelvis (51%), while in the miniperc and microperc groups, they were located mainly in the lower pole (46%, 53%, respectively). Stone-free rates after a single session were 77.2%, 86.1%, 88.8%, and 83.6% in the SWL, RIRS, microperc, and miniperc groups, respectively. Although no serious complications (above Clavien level III) were noted in any of the groups evaluated, Clavien I to II complications were common in the miniperc group. Conclusion: Although SWL is the preferred treatment option for patients with medium-sized (10–20 mm) renal stones, endourologic methods also have been found to have a significant role. Relatively lower complication rates along with higher stone-free status observed with the RIRS technique compared with percutaneous approaches have made this method a valuable option in the management of such stones in recent years.

Renal pelvis

Nephrology

Nephrostomy

10.1089/end.2014.0698

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The Association Between Mean Platelet Volume, Platelet Distribution Width, Platelet Count and Varicocele

Journal of Reconstructive Urology (2020)

Özgür Yazıcı Alper Kafkaslı Utku Can

Objective: The relationship between the increase in the mean platelet volume, which is the determinant of platelet activation, and vascular pathologies is known. Therefore, in order to elucidate varicocele etiopathogenesis, we aimed to examine whether there is an any connection among MPV and varicocele. Material and Methods: 348 patients who underwent unilateral varicocelectomy in our clinic between 2013 and 2019 were prospectively comprised in the study. Patient's age, MPV in complete blood count, platelet distribution width (PDW), platelet count (PC) and mean varicose vein diameters were recorded. These parameters were compared between patient groups (Group 1 is level 1 varicocele patients; Group 2 is level 2 varicocele patients and Group 3 is level 3 varicocele patients), which were divided according to the varicocele grades determined by scrotal Doppler USG and it was checked whether there was a difference between the groups. Results: Mean age of the patients was 27.6±7.1 years. While 44 of 348 patients had varicocele was right-sided, the remaining 304 patients had left-sided varicocele. Varicocele was Grade 3 in 71 (20.5%) patients, Grade 2 in 239 (68.7%) and Grade 1 in the remaining 38 (10.9%). The mean VVD (mm) value for all groups was 4.2±1.2. There was no significant difference between the groups in terms of age and TS (p=0.056 and p=0.071, respectively). There was a statistically significant difference between three groups in terms of PDW and MPV values (p=0.025 and p=0.018, respectively). Group 3 was significantly higher for both parameters than Group 1. According to the spearman correlation coefficient calculated by using VVD and PC, PDW, and MPV parameters, it was found that the VVD showed a significant positive correlation with PDW and MPV (r=0.190, p=0.002 and r=0.201, p=0.001 respectively). Conclusion: Based on the importance of the vascular component in the pathophysiology of varicocele, it should be emphasized that it supports the hypothesis that varicocele may be a component of systemic venous anomalies.

Mean platelet volume

10.5336/urology.2020-76294

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Factors affecting success in the treatment of proximal ureteral stones larger than 1 cm with extracorporeal shockwave lithotripsy in adult patients

Urolithiasis (2020)

Yavuz Güler Akif Erbin Alper Kafkaslı Çağdaş Gökhun Özmerdiven

Extracorporeal shockwave lithotripsy

Extracorporeal

Renal pelvis

10.1007/s00240-020-01186-7

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Citations (17)

MP67-07 THE PROTECTIVE EFFECTS OF PROPOLIS ON OXIDATIVE STRESS AND CRYSTAL DEPOSITION WITH HYPEROXALURIA INDUCED TUBULAR CELL INJURY IN RAT MODEL

The Journal of Urology (2016)

Fehmi Narter Alper Kafkaslı Oğuz Öztürk Özgür Yazıcı Mustafa Bilal Hamarat

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology II1 Apr 2016MP67-07 THE PROTECTIVE EFFECTS OF PROPOLIS ON OXIDATIVE STRESS AND CRYSTAL DEPOSITION WITH HYPEROXALURIA INDUCED TUBULAR CELL INJURY IN RAT MODEL Kamil Fehmi Narter, Alper Kafkasli, Oguz Ozturk, Ozgur Yazici, Bilal Hamarat, Sukran Sarikaya, and Kemal Sarica Kamil Fehmi NarterKamil Fehmi Narter More articles by this author , Alper KafkasliAlper Kafkasli More articles by this author , Oguz OzturkOguz Ozturk More articles by this author , Ozgur YaziciOzgur Yazici More articles by this author , Bilal HamaratBilal Hamarat More articles by this author , Sukran SarikayaSukran Sarikaya More articles by this author , and Kemal SaricaKemal Sarica More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1323AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Oxidative stress (OS) can be effective in the kidney stone formation. We aimed to evaluate the degree of crystalization (CaOx) as well as oxidant (ROS)/antioxidant status in the kidney tissues, serum samples and possible protective effect of verapamil (V) or propolis (P)(honey-bee antioxidant product) on hyperoxaluric rat model. METHODS A total of 60 SD rats (350 g) were divided into the 6 study groups contained 8 rats during early (7 days) and late (28 days) follow-up. Control group;12 rats. Ethylene glycol (EG) group (0.75%, drinking water) Verapamil group (EG+1 mg/kg V, feeding tube) Propolis group (EG+50 mg/kg P, feeding tube) Histopathological evaluations of crystalization in kidney tissue;Light microscopy 10% formalin/24 h, paraffin,4-lm- section, stain HE). After the homogenization tissue samples were equilibrated to 1 mg tissue/1 ml Phosphate Buffered Saline. Blood samples were centrifuged in 3000 rpm/5 min. ELISA tests of catalase (CAT), superoxide dismutase (SOD), total glutathione (GSH), nitric oxide (NO), malonil dialdehid (MDA), total anti-oxidant capacity (TAOC) have been used to evaluate oxidant/antioxidant status of tissue and serum samples (YH-Biosearch). The statistical analyses;GraphPad Prism 6.0 software, multiple t-tests and statistical significance the Sidak-Bonferroni method, α=1.000%. RESULTS Statistically significant results were indicated on graphs. ELISA tissue and serum levels (Fig.1) of all parameters were shown. Crystalization (CaOx) in V group (mild), in P group (Limited) and in without any protective agent (EG group)(extensive, dense) at late phase (Fig 2). Although, both V and P did tend to limit the degree of crystaliazation, it was significantly lower in P group than V group. CONCLUSIONS As a result of our study, the limitation of both crystalization and OS might be instituted by propolis. As clinical application of propolis in the prophylaxis of stone disease might limit the formation, especially in recurrent stone formers. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e883 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Kamil Fehmi Narter More articles by this author Alper Kafkasli More articles by this author Oguz Ozturk More articles by this author Ozgur Yazici More articles by this author Bilal Hamarat More articles by this author Sukran Sarikaya More articles by this author Kemal Sarica More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Propolis

10.1016/j.juro.2016.02.1323

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Efficacy of Local Agents Used in Premature Ejaculation Treatment

Research Square (Research Square) (2024)

Mustafa Bilal Hamarat Alper Kafkaslı Onur Küçüktopçu Berk Karatas

Abstract Premature ejaculation is a common sexual dysfunction in men. Some topical anesthetic agents are used in the treatment to reduce the hypersensitivity of the glans. The number of patients in studies showing the effectiveness of topical agents is limited. This study aimed to evaluate the effects of a eutectic mixture of lidocaine and prilocaine-containing local anesthetic creams(EMLA), lidocaine spray, and benzocaine condoms on ejaculation, which are widely used in Turkey in premature ejaculation patients. Between November 2020 and December 2022, 273 male patients who were admitted to the andrology policlinic of the hospital and diagnosed with PE for life were included in the study. Age, body mass index, marriage periods, intercourse durations, relationship frequency, comorbidities, duration of intravaginal ejaculation latency time(IELT) before and 2 months after treatment and side effects of the patients after treatment were prospectively collected. Patients were divided into 3 groups. Group 1 consisted of patients using EMLA cream, respectively; group 2 consisted of patients using lidocaine spray, and group 3 consisted of patients using benzocaine condoms. 59 people in group 1, 126 in group 2, and 88 in group 3 were included in the study. Pre-treatment IELT values of Groups 1, 2, and 3 were 32.5+17.7 sec, 29.8+17.9 sec, and 30.1+13.9 s, respectively. Post-treatment IELT values were 104.5+135.81 sec, 144.1+179.8 sec, and 75.1+50.4 s, respectively. In all three groups, post-treatment IELT values were significantly higher than before treatment. Our study found that spray and EMLA cream significantly increased IELT duration compared to condoms. Although local treatments used in premature ejaculation are effective in the short term, further studies showing long-term efficacy are needed.

Premature ejaculation

Ejaculation

10.21203/rs.3.rs-4006624/v1

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A prospective and randomised trial of efficacy and safety of transdermal oxybutynin versus oral oxybutynin in the management of children with overactive bladder

European Urology Open Science (2020)

A. Sevinc Ahmet Şahan Orkunt Özkaptan Alkan Çubuk Alper Kafkaslı

Oxybutynin

Tolterodine

10.1016/s2666-1683(20)33350-4

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