Yu Xi

First Affiliated Hospital of Soochow University

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Chunxiang Zhu

National University of Singapore

Albert Chin

National Yang Ming Chiao Tung University

Mingbin Yu

Agency for Science, Technology and Research

M.F. Li

Southern University of Science and Technology

Miao Sun

Liaoning Shihua University

D.S.H. Chan

Centre d'Études et de Recherches sur le Développement International

Likui Lu

First Affiliated Hospital of Soochow University

S.C. Rustagi

Sirim Berhad

Dim‐Lee Kwong

Agency for Science, Technology and Research

H.F. Lim

Ajou University

Cooperative Institutions

National University of Singapore

Soochow University

First Affiliated Hospital of Soochow University

Institute of Microelectronics

Agency for Science, Technology and Research

Shanghai Jiao Tong University

Nanjing Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Singapore Science Park

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The applications and advances of CRISPR-Cas9 in medical research

Briefings in Functional Genomics (2016)

Xiaojie Lu Hongmei Sun Yong Xu Yu Xi Biao Gu

10.1093/bfgp/elw036

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Citations (1)

High Performance ALD HfO 2-Al 2O 3 Laminate MIM Capacitors for RF and Mixed Signal IC Applications

International Electron Devices Meeting (2003)

Hang Hu Shi Jin Ding H.F. Lim Chunxiang Zhu M. F. Li

for RF and Mixed Signal IC Applications Hang Hu, Shi-Jin Ding, HF Lim, Chunxiang Zhu, M.F. Li , S.J. Kim, XF Yu, JH Chen, YF Yong, Byung Jin Cho, D.S.H. Chan, Subhash C Rustagi, MB Yu, CH Tung, Anyan Du, Doan My, PD Foo, Albert Chin, Dim-Lee Kwong SNDL, Dept. of ECE, National Univ. of Singapore, Singapore, 119260 Tel: 65-6874 8930, Fax: 65-6779 1103 Email: elezhucx@nus.edu.sg Institute of Microelectronics, Singapore, 117685, Dept. of Electronics Eng., National Chiao Tung Univ., Taiwan Dept. of Electrical & Computer Eng., Univ. of Texas, Austin, TX 78712, USA

Microelectronics

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R/S Analysis on Calendar Spread of CSI—300 Index Futures

Science Technology and Engineering (2010)

Yu Xi

The emperial research of the 1 minute data of the calendar spread of CSI—300 Index futures utilizing Hurst exponent and V statistics based on R/S analysis gives its Hurst exponent in(0.4,0.5) and the average loop cycle between(8,20) minutes.Such an outcome indicates that the calendar spread reflects a fractal market character with low-level anti-persistence.Because of the impact from arbitrage,the past tendency in calendar spread brings counter-effect in future,which is different from long-term memory of stock spot market.

Hurst exponent

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3-acetyl-11-keto-beta-boswellic acid decreases the malignancy of taxol resistant human ovarian cancer by inhibiting multidrug resistance (MDR) proteins function

Biomedicine & Pharmacotherapy (2019)

Jin Lü Yingchun Wang Zhujun Shi Yinan Wu Wu Dongchen

Recurrence of ovarian cancer is mainly due to multidrug resistance (MDR). 3-acetyl-11-keto-beta-boswellic acid (AKBA) could reverse the multidrug resistance in human ileocecal adenocarcinoma cells, but whether AKBA could modulate acquired MDR in ovarian cancer needs to be elucidated. The current study examined the effect of AKBA on ovarian cancer MDR using a Taxol resistant human ovarian cancer cell line A2780/Taxol. Cell proliferation, migration and invasion, the intracellular accumulation of Rhodamine 123 and expression of MDR proteins were studiedin vitro. Furthermore, the effect of AKBA on oncogenicity of A2780/Taxol cells in nude mice xenograft model was studied. The results showed that apart from its cytostatic and apoptosis-induction effect, AKBA could restrain A2780/Taxol cell migration and invasion. In addition, AKBA improved the sensitivity of A2780/Taxol cells to Taxol apparently, and the reversal of MDR by AKBA was evident by increasing intracellular Rhodamine 123 in cells. Furthermore, the anti-cancer potential of AKBA was evidenced as that AKBA treatment significantly slowed tumor growth and decreased the expression of P-gp, LRP, BCRP and MRP. Above results indicated that AKBA might be a potential compound to reverse MDR in human ovarian cancer.

Rhodamine 123

10.1016/j.biopha.2019.108992

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Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Molecular Cancer (2023)

Zhennan Yuan Yingpu Li Sifan Zhang Xueying Wang He Dou

The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis. Anticancer treatments including adjuvant therapies and targeted therapies are effective in eliminating cancer cells but in a limited number of patients. Increasing evidence suggests that the extracellular matrix (ECM) plays an important role in tumor development through changes in macromolecule components, degradation enzymes and stiffness. These variations are under the control of cellular components in tumor tissue via the aberrant activation of signaling pathways, the interaction of the ECM components to multiple surface receptors, and mechanical impact. Additionally, the ECM shaped by cancer regulates immune cells which results in an immune suppressive microenvironment and hinders the efficacy of immunotherapies. Thus, the ECM acts as a barrier to protect cancer from treatments and supports tumor progression. Nevertheless, the profound regulatory network of the ECM remodeling hampers the design of individualized antitumor treatment. Here, we elaborate on the composition of the malignant ECM, and discuss the specific mechanisms of the ECM remodeling. Precisely, we highlight the impact of the ECM remodeling on tumor development, including proliferation, anoikis, metastasis, angiogenesis, lymphangiogenesis, and immune escape. Finally, we emphasize ECM "normalization" as a potential strategy for anti-malignant treatment.

Tumor progression

10.1186/s12943-023-01744-8

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Citations (311)

Application of CRISPR/Cas9 in Alzheimer’s Disease

Frontiers in Neuroscience (2021)

Likui Lu Yu Xi Yongle Cai Miao Sun Hao Yang

Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disorder clinically characterized by cognitive impairment, abnormal behavior, and social deficits, which is intimately linked with excessive β-amyloid (Aβ) protein deposition along with many other misfolded proteins, neurofibrillary tangles formed by hyperphosphorylated tau protein aggregates, and mitochondrial damage in neurons, leading to neuron loss. Currently, research on the pathological mechanism of AD has been elucidated for decades, still no effective treatment for this complex disease was developed, and the existing therapeutic strategies are extremely erratic, thereby leading to irreversible and progressive cognitive decline in AD patients. Due to gradually mental dyscapacitating of AD patients, AD not only brings serious physical and psychological suffering to patients themselves, but also imposes huge economic burdens on family and society. Accordingly, it is very imperative to recapitulate the progress of gene editing-based precision medicine in the emerging fields. In this review, we will mainly focus on the application of CRISPR/Cas9 technique in the fields of AD research and gene therapy, and summarize the application of CRISPR/Cas9 in the aspects of AD model construction, screening of pathogenic genes, and target therapy. Finally, the development of delivery systems, which is a major challenge that hinders the clinical application of CRISPR/Cas9 technology will also be discussed.

10.3389/fnins.2021.803894

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Citations (34)

Manipulating and measuring polarizations conversion of electromagnetic wave by anisotropic metamaterials

College Physics (2009)

Yu Xi

Reflected from anisotropic metamateiral slab,polarization states of electromagnetic wave can be manipulated with great freedom,and may have complete polarization conversion under certain conditions.In this paper we present our designing and performing of an experiment aimed at measuring the polarization conversion of electromagnetic wave,based on the laboratory's microwave system.We show the result of our experiment as we found considerable polarization conversion at certain frequencies.We also purpose a new approach to enhance the polarization conversion ratio(PCR)and have testified it through experiment.Numerical simulations are employed to compare with the experimental result.

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Relationship between miR-34a/SIRT1 expression and cataract in rats

Chin J Clinicians(Electronic Edition) (2017)

Qingshan Ji Yu Xi Siqin Sun Yuechun Wen Genjie Ke

Objective To detect the changes in the expression levels of miR-34a/SIRT1 and P53 in cataract lens in rats. Methods Thirty-six lenses from SD rats were divided into three groups: clear lenses of young and old rats and cataractous lenses. Expression of miR-34a/SIRT1 mRNA in the clear lenses of young and old rats and cataractous lenses was detected by real-time RT-PCR, and SIRT1 and P53 expression was detected by Western blot. Results Real-time PCR analysis showed that miR-34a expression was significantly up-regulated, accompanied by down-regulation of SIRT1 mRNA expression in rat cataractous lenses (t = 12.60, P = 0.0002; t = 3.299, P = 0.03, respectively). miR-34a expression was significantly lower (t = 9.609, P = 0.0007) and SIRT1 mRNA expression was significantly higher (t = 7.242, P = 0.0019) in clear lenses of old rats than in clear lenses of old lenses. Western blot analysis showed that SIRT1 protein expression was significantly down-regulated, accompanied by up-regulated expression of acetylated P53 protein in rat cataractous lenses (t = 8.924, P = 0.0009; t = 9.280, P = 0.0008, respectively). SIRT1 protein expression was significantly higher (t = 3.419, P = 0.0345) and acetylated P53 protein expression was significantly lower (t = 4.768, P = 0.0089) in clear lenses of old rats than in clear lenses of old lenses. Conclusion High expression of miR-34a is related to cataract in rats, possibly by decreasing SIRT1 protein expression and promoting the acetylation of P53. Key words: Cataract; miR-34a/SIRT1; P53; Lens

Crystallin

10.3877/cma.j.issn.1674-0785.2017.13.005

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Interface traps at high doping drain extension region in sub-0.25-/spl mu/m MOSTs

IEEE Electron Device Letters (2001)

G. Chen M.F. Li Yu Xi

A huge bulk (or drain) current I/sub b/ (or I/sub d/) peak versus gate voltage was observed for the 0.25-μm or sub-0.25-μm metal-oxide-semiconductor field effect transistors (MOSTs) with high doping concentration source/drain extension, when the drain-bulk p-n junction is forward biased. This current is increased under Fowler-Nordheim (FN) or channel hot carrier (CHC) stress and is identified as thermal-trap-tunneling electron current at the drain extension-gate overlap region. It is extremely sensitive that one interface trap will induce 0.1 pA current increment of peak I/sub b/ (or I/sub d/).

Trap (plumbing)

10.1109/55.919239

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Potency Increase of Spiroketal Analogs of Membrane Inserting Indolyl Mannich Base Antimycobacterials Is Due to Acquisition of MmpL3 Inhibition

ACS Infectious Diseases (2020)

Ming Li Zheng Yen Phua Yu Xi Zhujun Xu Samuel Agyei Nyantakyi

Chemistry campaigns identified amphiphilic indolyl Mannich bases as novel membrane-permeabilizing antimycobacterials. Spiroketal analogs of this series showed increased potency, and the lead compound

10.1021/acsinfecdis.0c00121

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Citations (15)