Richard P. Newman

Clinical Physiology Associates

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Peter A. LeWitt

Wayne State University

Donald B. Calne

University of British Columbia

Norman L. Foster

University of Utah

Thomas N. Chase

MacEwan University

Richard S. Burns

Auburn University

Thomas Larsen

Aarhus University

Borivoj Vojnovic

University of Oxford

L. Jacobs

Great Ormond Street Hospital for Children NHS Foundation Trust

Lawrence Jacobs

Anne Arundel Medical Center

Elizabeth J. B. Manning

Florey Institute of Neuroscience and Mental Health

Cooperative Institutions

National Institutes of Health

National Institute of Neurological Disorders and Stroke

University of Oxford

CRUK/MRC Oxford Institute for Radiation Oncology

Cancer Research UK

Medical Research Council

Cleveland Clinic

University at Buffalo, State University of New York

National Institute of Mental Health

Harvard University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Bromocriptine and lisuride in dystonias

Neurology (1984)

Stephen M. Stahl Philip A. Berger Richard P. Newman Peter Le Witt

Lisuride

10.1212/wnl.34.1.135-a

Cite

Citations (11)

Metoprolol in Essential Tremor

Archives of Neurology (1980)

Richard P. Newman L. Jacobs

The tremor of a patient with debilitating essential tremor who could not take propranolol (because of severe asthma) was dramatically reduced when metoprolol tartrate was administered in standard doses. Metoprolol appears to be an excellent alternative antitremor drug to propranolol in such patients.

Metoprolol Tartrate

10.1001/archneur.1980.00500580092022

Cite

Citations (34)

Paroxysmal Choreoathetosis due to Hypoglycemia

Archives of Neurology (1984)

Richard P. Newman William R. Kinkel

Acquired paroxysmal choreoathetosis may result from various structural and metabolic disorders.¹We report on a diabetic patient in whom choreoathetosis was a manifestation of hypoglycemia.

REPORT OF A CASE

A 45-year-old woman with long-standing insulin-dependent diabetes mellitus appeared at the emergency room with a severe headache, nausea, and emesis. She was given an injection of 0.5 mL of hydromorphone hydrochloride and after 1½ hours she suddenly became stuporous. Fifteen minutes later she was more awake but very confused. She suddenly manifested vigorous choreoathetosis of all four extremities, opisthotonus, and facial grimacing. There was hypotonia of the extremities, but no evidence of weakness. Deep tendon reflexes were absent in the lower extremities. There was no diaphoresis, tremor, or tachycardia. The remainder of the neurologic examination results were normal. The patient had no history of drug ingestion, specifically haloperidol or phenothiazines, and there was no family history of neurologic disorder.

Choreoathetosis

Hydromorphone

10.1001/archneur.1984.04050150123033

Cite

Citations (63)

Treatment of resting tremor by beta-adrenergic blockade

American Heart Journal (1984)

Norman L. Foster Richard P. Newman Peter A. LeWitt Marjorie Gillespie Thomas N. Chase

Nadolol

Resting tremor

10.1016/0002-8703(84)90603-3

Cite

Citations (7)

Effortful and automatic memory

Neurology (1984)

Richard P. Newman Herbert Weingartner Sheila A. Smallberg Donald B. Calne

With advancing age, there are changes in both cognitive functions and neurotransmitter metabolism. Dopamine plays a role in learning, memory, and related cognitive processes. We evaluated the effects of supplemental dopamine in precursor form (levodopa) on various aspects of memory in elderly normal volunteers in a controlled, double-blind study. Access to semantic memory and automatic processes were unaffected, but levodopa reliably facilitated effortful memory processing. Levodopa may be useful clinically in attenuating impairments in effortful cognitive tasks. Different neural systems probably mediate different forms of cognition.

Neurotransmitter Systems

10.1212/wnl.34.6.805

Cite

Citations (63)

Episodic hyperhidrosis, hypothermia, and agenesis of corpus callosum

Neurology (1983)

Peter A. LeWitt Richard P. Newman Harry S. Greenberg Leslie L. Rocher Donald B. Calne

Episodic hyperhidrosis and hypothermia are the primary symptoms of a rare central nervous system disorder of thermoregulation which is often associated with agenesis of the corpus callosum and can present in childhood or adult years. During attacks, patients may exhibit confused, withdrawn, and lethargic behavior and ataxia or other neurologic symptoms. A 21-year-old man with temperature chronically between 30 and 32 °C transiently responded to phenobarbital and to cyproheptadine therapy. A 34-year-old woman with frequent, brief episodes of hypothermia and hyperhidrosis improved with chlorpromazine treatment. Episodic thermoregulatory disturbance has been atttributed to “vagal attacks” or “diencephalic epilepsy,” but the pathophysiology remains undefined.

10.1212/wnl.33.9.1122

Cite

Citations (60)

EMD 23,448: Effects of a putative dopamine autoreceptor agonist in chorea

Journal of Neural Transmission (1985)

Richard P. Newman Carol A. Tamminga Th. N. Chase Peter A. LeWitt

Autoreceptor

Pramipexole

10.1007/bf01253057

Cite

Citations (3)

A unique protein in normal human cerebrospinal fluid.

Clinical Chemistry (1983)

Nicholas M. Papadopoulos Peter A. LeWitt Richard P. Newman M I Raphaelson T. N. Chase

On analysis of cerebrospinal fluid (CSF) samples from normal volunteer donors by high-resolution zone electrophoresis on agarose gel, an electrophoretically homogeneous protein band consistently appeared in the gamma-globulin region. Application of immunofixation electrophoresis in attempts to identify the band with use of monospecific antibodies against individual human serum proteins and against heavy- and light-chain immunoglobulins as well as polyvalent antisera did not produce a positive immunoprecipitation reaction with the protein band. The serum samples from these subjects did not show similar bands. Therefore, we conclude that this protein band is a normally occurring protein that is unique to CSF.

Immunofixation

Immunoprecipitation

Myeloma protein

Serum protein electrophoresis

Agarose gel electrophoresis

Cerebrospinal fluid proteins

Agarose

10.1093/clinchem/29.10.1842

Cite

Citations (5)

Tetrahydrobiopterin in dystonia

Neurology (1986)

Peter A. LeWitt Leonard P. Miller Robert A. Levine Walter Lovenberg Richard P. Newman

The pteridine cofactor of tyrosine and tryptophan hydroxylases, tetrahydrobiopterin (BH4), is concentrated in the striatum and other sites of brain monoamine synthesis and is a regulatory factor in the rate-limiting step of catecholamine synthesis. CSF content was decreased in eight patients with dystonic disorders (mean, 13.0 +/- 0.8 pmol/ml CSF compared with 20.6 +/- 1.4 in age-matched normals). We gave several trials of synthetic BH4 intravenously to 10 dystonic patients with benefit for 2 subjects with diurnally fluctuating dystonia, 1 with hemidystonia and parkinsonism, and 1 with generalized torsion dystonia. The findings of biopterin abnormality and the observed clinical improvements may point to a role for the cofactor in the pathogenesis and, possibly, the treatment of some forms of primary dystonia.

Biopterin

Putamen

GTP cyclohydrolase I

Tetrabenazine

10.1212/wnl.36.6.760

Cite

Citations (62)

Hyperbaric Chamber Treatment-Reply

Archives of Neurology (1981)

Richard P. Newman Elizabeth J. B. Manning

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal

10.1001/archneur.1981.00510020094020

Cite

Citations (0)