The paper has developed and proposed a synthesis analysis method based on the robust satellite data analysis technique(RST) to detect seismic anomalies within the bi-angular advanced along-track scanning radiometer(AATSR) gridded brightness temperature(BT)data based on spatial/temporal continuity analysis. The proposed methods have been applied to analyze the Yushu(Qinghai, China) earthquake occurred on 14 th April 2010,and a full AATSR data-set of 8 years data from March2003 to May 2010 with longitude from 91°E to 101°E and latitude from 28°N to 38°N has been analyzed. Combining with the tectonic explanation of spatial and temporal continuity of the abnormal phenomena, the analyzed results indicate that the infrared radiation anomalies detected by the AATSR BT data with nadir view appear and enhance gradually along with the development and occurring of the earthquake, especially along the Ganzi-Yushu fault, Nu River fault and Jiali-Chayu fault; more infrared anomalies along the earthquake fault zone(Lancangjiang fault and Ning Karma Monastery-Deqin fault) are detected using the proposed synthesis analysis method, which can also characterize the activity of seismic faults more precisely.
AIM:To explore the association between AT-rich interactive domain 1A(ARID1A)protein loss by immunohistochemistry and both clinicopathologic characteristics and prognosis in patients with colorectal cancer.METHODS:We retrospectively collected clinicopathologic data and archived paraffin-embedded primary colorectal cancer samples from 209 patients,including 111patients with colon cancer and 98 patients with rectal cancer.The tumor stage ranged from stageⅠto stageⅣaccording to the 7th edition of the American Joint Committee on Cancer tumor-node-metastasis(TNM)staging system.All patients underwent resection of primary colorectal tumors.The expression of ARID1A protein in primary colorectal cancer tissues was examined by immunohistochemical staining.The clinicopathologic association and survival relevance of ARID1A protein loss in colorectal cancer were analyzed.RESULTS:ARID1A loss by immunohistochemistry was not rare in primary colorectal cancer tumors(25.8%).There were 7.4%,24.1%,22.2%and 46.3%of patients with ARID1A loss staged at TNM stageⅠ,Ⅱ,ⅢandⅣ,respectively,compared with 20.0%,22.6%,27.7%and 29.7%of patients without ARID1A loss staged at TNM stageⅠ,Ⅱ,ⅢandⅣ,respectively.In patients with ARID1A loss,the distant metastasis rate was 46.3%.However,only 29.7%of patients without ARID1A loss were found to have distant metastasis.In terms of pathologic differentiation,there were 25.9%,66.7%and 7.4%with poorly,moderately and well differentiated tumors in patients with ARID1A loss,and 14.2%,72.3%and 13.5%with poorly,moderately and well differentiated tumors in patients without ARID1A loss,respectively.ARID1A loss was associated with late TNM stage(P=0.020),distant metastasis(P=0.026),and poor pathological classification(P=0.035).However,patients with positive ARID1A had worse overall survival compared to those with negative ARID1A in stageⅣcolorectal cancer(HR=2.49,95%CI:1.13-5.51).CONCLUSION:ARID1A protein loss is associated with clinicopathologic characteristics in colorectal cancer patients and w
microRNAs(miRNAs) play an important regulatory role in the self-renewal and differentiation of stem cells. In this study, we examined the effects of miRNA-124(miR-124) overexpression in bone marrow-derived mesenchymal stem cells. In particular, we focused on the effect of overexpression on the differentiation of bone marrow-derived mesenchymal stem cells into neurons. First, we used GeneChip technology to analyze the expression of miRNAs in bone marrow-derived mesenchymal stem cells, neural stem cells and neurons. miR-124 expression was substantially reduced in bone marrow-derived mesenchymal stem cells compared with the other cell types. We constructed a lentiviral vector overexpressing miR-124 and transfected it into bone marrow-derived mesenchymal stem cells. Intracellular expression levels of the neuronal early markers β-III tubulin and microtubule-associated protein-2 were significantly increased, and apoptosis induced by oxygen and glucose deprivation was reduced in transfected cells. After miR-124-transfected bone marrow-derived mesenchymal stem cells were transplanted into the injured rat spinal cord, a large number of cells positive for the neuronal marker neurofilament-200 were observed in the transplanted region. The Basso-Beattie-Bresnahan locomotion scores showed that the motor function of the hind limb of rats with spinal cord injury was substantially improved. These results suggest that miR-124 plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells into neurons. Our findings should facilitate the development of novel strategies for enhancing the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation for spinal cord injury.
当前，南京南方火车站计划实现板岩房顶革新把太阳能电池模块正在集成到传统的房顶材料产生干净精力。Copperindiumgallium diselenide (CuIn1x Ga x Se2，帝国参谋总长) 是为薄电影太阳能电池的最有希望的材料之一。Se2 拍摄的 Cu (In1x Ga x ) 被一步舞收音机频率扔在低底层温度的磁控管劈啪作响过程。X 光检查衍射，拉曼，扫描电子显微镜学，精力散的 X 光检查光谱学，和电、光的大小被执行调查扔的电影。结果揭示那 320 驴的温度(Microp
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