Yongzhen Mo

Central South University

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Zhaoyang Zeng

Central South University

Wei Xiong

Central South University

Guiyuan Li

Central South University

Can Guo

Central South University

Yumin Wang

Central South University

Qianjin Liao

Hunan Normal University

Qijia Yan

Xiangya Hospital Central South University

Zhaojian Gong

Second Xiangya Hospital of Central South University

Bo Xiang

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Fuyan Wang

Hunan Cancer Hospital

Cooperative Institutions

Central South University

135

Hunan Cancer Hospital

Xiangya Hospital Central South University

Third Xiangya Hospital

Second Xiangya Hospital of Central South University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Chinese Academy of Sciences

Sun Yat-sen University

Fudan University

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Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA

Science China Life Sciences (2022)

Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou

10.1007/s11427-021-2089-8

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Citations (16)

Additional file 6 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Figshare (2022)

Yongzhen Mo Yumin Wang Yian Wang Xiangying Deng Qijia Yan

Additional file 6: Supplemental Table 6. The potential β-TrCP-interacting proteins in CNE2 cells identified by LC-MS/MS spectrometry after pull-down with β-TrCP antibody.

10.6084/m9.figshare.21285843

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Neutrophils: Accomplices in metastasis

Cancer Letters (2020)

Kunjie Zhu Panchun Li Yongzhen Mo Jie Wang Xianjie Jiang

Circulating tumor cell

Primary tumor

10.1016/j.canlet.2020.07.028

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Citations (22)

Circular RNAs in human cancer

Molecular Cancer (2017)

Yumin Wang Yongzhen Mo Zhaojian Gong Xiang Yang Mo Yang

CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique structure, they are more stable than linear RNAs. CircRNAs play important roles in the carcinogenesis of cancer. The expression of circRNAs is correlated with patients' clinical characteristics, and circRNAs play a vital role in many aspects of malignant phenotypes, including cell cycle, apoptosis, vascularization, and invasion; metastasis as a RNA sponge, binding to RBP; or translation. Therefore, it is meaningful to further study the mechanism of interactions between circRNAs and tumors. The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.

Circular RNA

10.1186/s12943-017-0598-7

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Citations (345)

CircARHGAP12 promotes nasopharyngeal carcinoma migration and invasion via ezrin-mediated cytoskeletal remodeling

Cancer Letters (2020)

Chunmei Fan Hongke Qu Fang Xiong Yanyan Tang Ting Tang

10.1016/j.canlet.2020.09.006

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Citations (60)

Additional file 7 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Figshare (2022)

Yongzhen Mo Yumin Wang Yian Wang Xiangying Deng Qijia Yan

Additional file 7: Supplemental Table 7. Proteomic analysis of circPVT1-regulated proteins in CNE2 cells after transfected with the circPVT1overexpression or empty vectors, followed by LC-MS/MS spectrometry.

Circular RNA

10.6084/m9.figshare.21285846

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Additional file 3 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Figshare (2022)

Yongzhen Mo Yumin Wang Yian Wang Xiangying Deng Qijia Yan

Additional file 3: Supplemental Table 3. Probes for fluorescence in situ hybridization and RNA pulldown, siRNAs, primers for qRT-PCR and vector construction.

10.6084/m9.figshare.21285834

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Bioinformatics Analysis of the Signaling Pathways and Genes of Gossypol Induce Death of Nasopharyngeal Carcinoma Cells

DNA and Cell Biology (2021)

Kunjie Zhu Junshang Ge Yi He Panchun Li Xianjie Jiang

Gossypol has been reported to exhibit antitumor effects against several human cancers. However, the anticancer effects of gossypol on nasopharyngeal carcinoma (NPC) have not been investigated. Against this backdrop, the present study was designed to evaluate the anticancer effects of gossypol against NPC cells and to identify the signaling pathways involved through bioinformatic analysis. Gossypol-inhibited death of NPC cells is concentration-dependent. To explore the underlying mechanism for gossypol's antitumor effect, microarray of gossypol-treated and -untreated NPC cells was performed. A total of 836 differentially expressing genes (DEGs) were identified in gossypol-treated NPC cells, of which 461 genes were upregulated and 375 genes were downregulated. The cellular components, molecular functions, biological processes, and signal pathways, in which the DEGs were involved, were identified by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The Gene Set Enrichment Analysis (GSEA) predicted upstream transcription factors (TF) ETS2 and E2F1 that regulate DEGs. Weighted Gene Co-expression Network Analysis (WGCNA) was performed to identify a class of modules and genes related to DNA repair and cell cycle. TNFRSF10B, a receptor for death in NPC cells, was knocked down. The results suggested that the ability of NPC cells to resist gossypol killing was enhanced. In addition, to further investigate the possible molecular mechanisms, we constructed a transcriptional regulatory network of TNFRSF10B containing 109 miRNAs and 47 TFs. Taken together, our results demonstrated that gossypol triggered antitumor effects against NPC cells, indicating its applicability for the management of NPC.

Gossypol

KEGG

10.1089/dna.2020.6348

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Gossypol induces apoptosis of multiple myeloma cells through the JUN-JNK pathway.

PubMed (2020)

Luyuan Zhang Sinan Sun Yumin Wang Yongzhen Mo Fang Xiong

Multiple myeloma (MM) is one of the most common hematologic neoplastic diseases. Gossypol was once used as a male contraceptive but is considered a novel antitumor agent. This study aimed to reveal the gossypol-induced apoptosis mechanism and its hub genes. Gossypol-induced MM cell apoptosis is concentration- and time-dependent. Of a total of 532 differentially expressed genes, 273 genes were upregulated and 259 genes were downregulated in gossypol-treated MM cells. Through KEGG and WGCNA analyses, the apoptosis-associated module was identified, and JUN was identified as the hub gene. The expression of the JUN protein product c-Jun was downregulated in MM cell lines compared to that in normal plasma cells. High-risk MM patients had a lower expression of JUN. High-expression JUN group patients had a lower risk of death. JUN overexpression in MM cells induced potent cell death and growth inhibition by a caspase-dependent apoptotic mechanism. DR5 is one of the upstream receptors of the JNK pathway, and shRNA knockdown of DR5 can partially reverse gossypol-induced apoptosis. A total of 1017 genes were coexpressed with JUN in MM patients. These genes are mainly involved in other JNK-associated signaling pathways, such as the IL6, EGF and PDGF signaling pathways. In conclusion, JUN is identified as the hub gene in gossypol-induced apoptosis, and gossypol can activate caspase-dependent apoptosis through the JNK pathway by targeting c-Jun and other JNK-associated pathways. DR5 and IL6 are also involved in this mechanism.

Gossypol

c-jun

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Transfer RNA-derived small RNAs in tumor microenvironment

Molecular Cancer (2023)

Mei Yang Yongzhen Mo Daixi Ren Shun Liu Zhaoyang Zeng

Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in organisms. With certain modifications and under specific conditions, tRNAs can be sheared and fragmented into small non-coding RNAs, also known as tRNA-derived small RNAs (tDRs). With the development of high-throughput sequencing technologies and bioinformatic strategies, more and more tDRs have been identified and their functions in organisms have been characterized. tRNA and it derived tDRs, have been shown to be essential not only for transcription and translation, but also for regulating cell proliferation, apoptosis, metastasis, and immunity. Aberrant expression of tDRs is associated with a wide range of human diseases, especially with tumorigenesis and tumor progression. The tumor microenvironment (TME) is a complex ecosystem consisting of various cellular and cell-free components that are mutually compatible with the tumor. It has been shown that tDRs regulate the TME by regulating cancer stem cells, immunity, energy metabolism, epithelial mesenchymal transition, and extracellular matrix remodeling, playing a pro-tumor or tumor suppressor role. In this review, the biogenesis, classification, and function of tDRs, as well as their effects on the TME and the clinical application prospects will be summarized and discussed based on up to date available knowledge.

10.1186/s12943-023-01742-w

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Citations (29)