Ryosaku Takashina

Kyoto Prefectural University of Medicine

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Hamao Ijichi

Kyoto University

Hakuo Takahashi

Kansai Medical University

Rieko Shikuma

University of Alabama

Kazuo Takeda

Research Organization for Information Science and Technology

Hideaki Yamazaki

Tokai University

Manabu Yoshimura

Ube (Japan)

Manabu Yoshimura

Kawasaki University of Medical Welfare

Susumu Sasaki

Niigata University

Hiroshi Ashizawa

Shizuoka Cancer Center

Hiroshi Okajima

Kumamoto University

Cooperative Institutions

Kyoto Prefectural University of Medicine

Kyoto University

Nantan General Hospital

The University of Tokyo

Shiga University

Fujita Health University

Japan Industrial Safety and Health Association

Nihon University

Kagoshima University

Jikei University School of Medicine

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[Role of adrenal catecholamines on the synthesis of renal catecholamines].

PubMed (1986)

Hideaki Yamazaki Manabu Yoshimura S Kanbara Ryosaku Takashina K. Takeda

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Citations (1)

9 YEARS FOLLOW UP STUDY IN THE CHANCE HYPERTENSION OBTAINED IN ONE MEDICAL EXAMINATION : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society

Japanese Circulation Journal-english Edition (1984)

Ken Takeda Hideaki Okajima Shunichi Yoneda H. Tomioka ISAO IYODA

Circulation (fluid dynamics)

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The Effect of Dopaminergic Antagonists on Plasma Aldosterone in Normal Subjects and Patients with Hypopituitarism

Folia Endocrinologica Japonica (1984)

Rieko Shikuma Manabu Yoshimura Ryosaku Takashina Hideaki Yamazaki Seiichi Kambara

Although angiotensin II, ACTH and potassium are generally acknowledged as major factors in regulating the influences on aldosterone secretion, it has recently been reported that dopamine is a potent inhibitor of aldosterone secretion in man and animals. In the present study, we investigated the effect of two kinds of dopaminergic receptor antagonists, metoclopramide and sulpiride, on plasma aldosterone concentration (PAC) and serum prolactin (PRL) in man. Normotensive volunteers and patients with hypopituitarism were injected with metoclopramide (10 mg i.v.) or sulpiride (10 mg i.m.). In normal volunteers, metoclopramide increased both PAC and PRL levels, and showed a maximum level at 30 minutes after injection. In patients with hypopituitarism, PAC tended to increase without change of PRL, which suggested that the increase in PAC by metoclopramide might have a direct inhibitory effect on the dopaminergic receptor in the adrenal gland. Moreover another antagonist, sulpiride also increased PRL but contrary tended to decrease PAC. These results suggested that PRL responses to both inhibitors were mediated by dopaminergic antagonist activity at the level of pituitary receptors. However dopamine-induced modulation of aldosterone secretion may be different from that of PRL at dopaminergic receptors. These results suggested that modulatory inhibition of aldosterone secretion by dopamine may be affected by difference of affinity of dopamine to receptor as organ specificity, or different affinity of metoclopramide and sulpiride to adrenal dopamine receptor.In conclusion, dopamine antagonist metoclopramide increased both PAC and PRL level, but the other antagonist, sulpiride, increased PRL and tended to decrease PAC.

10.1507/endocrine1927.60.9_1041

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Studies on Central Cholinergic Vasopressor Mechanims in Spontaneously Hypertensive Rats

Japanese Heart Journal (1982)

Atsushi Inoue Hakuo Takahashi Kazuo Takeda Hiroshi Ashizawa Rieko Shikuma

10.1536/ihj.23.433

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SYMPATHO-ADRENAL hyperactivity during shaking stress in awake spontaneously hypertensive rats

Japanese Heart Journal (1983)

Hiroshi Okajima Kazuo Takeda H Yamasaki Ryosaku Takashina Rieko Shiguma

10.1536/ihj.24.837

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[Role of the adrenal medulla in elevation of blood pressure induced by sodium loading].

PubMed (1986)

Hideaki Yamazaki Manabu Yoshimura S Kanbara Ryosaku Takashina Hitoshi Takahashi

Elevation (ballistics)

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Enhanced Pressor Responses to Intracisternal Injection of Hypertonic Saline and It's Brain mechanisms in urethane Anesthetized SHR

Japanese Heart Journal (1982)

Kazuo Takeda Hiroshi Asizawa Hakuo Takahashi Atsushi Inoue Rieko Shikuma

Hypertonic saline

10.1536/ihj.23.436

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Irregular isoantibodies in the sera of patients undergoing chronic hemodialysis

Jinko Toseki Kenkyukai kaishi/Jinkō Tōseki Kenkyūkai kaishi (1982)

Shuji Katoh Norihiko Maebo Masaaki Kohda Tadashi Nakanishi M Yoshiga

血液透析療法の確立により, 慢性血液透析患者の長期生存が可能となるにつれ, 種々合併症が問題とされている.この1つとして, 慢性血液透析患者に認められる不規則抗体について検討することを目的とした. スクリーニング法には食塩水法, アルブミン法, 抗グロブリン法, ブロメリン法を併用し, 血液透析導入前, 導入後は3-6か月ごとにスクリーニングを行い, 不規則抗体の存在する場合には同定検査を行った.その結果, 全く輸血歴がなく, 臨床症状もない2名の慢性血液透析患者に不規則抗体を検出した. 症例1は抗HI抗体であり, 抗体価は2倍であった. また, 患者の血液型はA1, Rh1rh (CcDee), NNss, Le(a+b-), P2で, 直接抗グロブリン試験は陰性であった. さらに, 成人O群赤血球を用いた寒冷凝集反応が32倍であることから, 本患者に検出された不規則抗体は抗HI特異性をもつ寒冷凝集素と考えられた.症例2は抗P1抗体で, 抗体価は2倍であった. また, 患者の血液型はA1, Rh1Rh1 (CCDee), MMss, Le(a-b-), P2で, 直接抗グロブリン試験は陰性であった.本邦では慢性血液透析患者に不規則抗体が認められたとの報告はきわめて少ない. しかし, 著者らの検討では慢性血液透析患者では従来, 最も不規則抗体が高頻度に認められるとされている経産婦群より高い. しかも, 慢性血液透析患者に不規則抗体が存在する場合, 患者が将来, 輸血, 手術, 腎移植等に遭遇する機会を考慮すると, 臨床上, きわめて重要な意義をもつことが予想される.以上から, 慢性血液透析患者では不規則抗体のスクリーニングの必要性が痛感される.

Isoantibodies

10.4009/jsdt1968.15.33

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Effect of prostaglandin E1 on renin and aldosterone in hypertensive patients.

Endocrinologia Japonica (1979)

Manabu Yoshimura Hakuo Takahashi Ryosaku Takashina Yoshihiro Kajita Tadayoshi Miyazaki

The effect of prostaglandin E1 (PGE1) on plasma renin activity (PRA) and plasma aldosterone concentration (PAC) was studied in the hypertensive subjects treated with or without 75 mg indomethacin or 60 mg propranolol for a week. Subsequent to the treatment with indomethacin for a week, PRA and PAC levels were decreased as compared to the control, without changes in the blood pressure and heart rate. During the infusion of PGE1, the blood pressure was decreased and the pulse rate was increased. PRA and PAC levels were also elevated. These changes of parameters were not different between the control and the indomethacin-treated subjects. PRA and PAC were suppressed after the treatment with propranolol. With the infusion of PGE1, the level of PRA was not significantly elevated, while, PAC was significantly increased by the infusion of 100 ng/Kg/min of PGE1. During the infusion of PGE1, the blood pressure was decreased while the pulse rate was increased in the subjects treated with propranolol. However, the elevation of the pulse rate was less remarkable than the control. These data indicate that PGE1 have important roles in the regulation of the release of renin and aldosterone. These findings also suggest that PGE1 may act to stimulate the secretion of aldosterone in man.

Plasma renin activity

Prostaglandin E1

10.1507/endocrj1954.26.481

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Citations (4)

[Dopaminergic modulation of salt sensitivity in essential hypertension].

PubMed (1984)

Rieko Shikuma Seichi Kambara Manabu Yoshimura Ryosaku Takashina Hiroshi Yamasaki

Modulation (music)

Essential hypertension

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Citations (4)