Three steps of two novel ligands of Indomethacin hydrazide based Schiff bases ligands were synthesized. For our targeted ligands, first we synthesized Indomethacin Ethyl Ester (RCOOC 2 H 5 ), This ester was further reacted with hydrazine hydrate to produce Indomethacin acid hydrazide (RCONHNH 2 ). Finally, this hydrazide condensed with o -Vanillin and p -Vanillin to get targeted compounds. Structure confirmation was characterized based on IR, 1 H-NMR and 13 C-NMR spectroscopy. Keywords: NSIADs, Indomethacin, o -Vanillin, p- Vanillin, acid hydrazide, Hydrazone, transition metal complexes, Hydrazide Base Schiff Bases.
