D. Junghans

University of Rostock

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Holger Kaftan

Helios Klinikum Erfurt

Achim Beule

University Hospital Münster

W. Hosemann

Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde

Achim Göpferich

University of Regensburg

W.‐D. Pfeiffer

Universität Greifswald

Peter Langer

University of Rostock

H Bernhardt

Universität Greifswald

M Knoke

Seattle Pacific University

G Schwesinger

Universität Greifswald

G Lorenz

Defense Health Agency

Cooperative Institutions

Universität Greifswald

Universitätsmedizin Greifswald

University of Rostock

University of Regensburg

Institut für Hygiene und Umwelt

University of Applied Sciences Stralsund

Medical University of Vienna

Universitäts-HNO-Klinik Heidelberg

Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde

Leibniz Institute for Catalysis

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Traumatische Trommelfellperforationen

HNO (2004)

Holger Kaftan W. Hosemann D. Junghans Achim Göpferich E. Schindler

10.1007/s00106-004-1126-9

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Citations (13)

ChemInform Abstract: Cyclization of 4‐Phenylthiosemicarbazide with Phenacylbromide Revisited. Formation of 1,3,4‐Thiadiazines and of Isomeric 1,3‐Thiazoles.

ChemInform (2015)

W.‐D. Pfeiffer D. Junghans Ashot S. Saghyan Peter Langer

Abstract Previously reported condensation of phenacyl bromide (I) with phenylthiosemicarbazide (II) gave mainly the corresponding 1,3,4‐thiadiazine (III) while formation of 2‐phenylimino‐4‐phenyl‐2,3‐dihydro‐1,3‐thiazol‐3‐amine (IV) needs harsher conditions, e.

10.1002/chin.201504128

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Candidosis and aspergillosis as autopsy findings from 1994 to 2003

Mycoses (2005)

G Schwesinger D. Junghans Guido Schröder H Bernhardt M Knoke

We analysed the autopsy records of the Greifswald University Institute of Pathology (located in Eastern Germany) in respect of findings of candidosis and aspergillosis from 1994 to 2003. We also present eight immature aborted fetuses and premature infants with a mycosis. In a total of 2027 autopsies we found 164 cases of invasive candidosis and aspergillosis (8.1%) including a combination of both on four occasions. Other authors cited between 0.7 and 7.3%. In these 10 years in our material mycoses and in particular candidosis increased in spite of slightly decreased numbers of autopsies. The differences comparing the 5-years periods (1994-98 and 1999-2003) are highly significant for both mycoses and candidosis. They are not significant for aspergillosis. A similar relationship was observed in the distribution of mycotic organs and causative origin for candidosis alone. In the last 5 years the gastrointestinal and respiratory tracts, including the peritoneum, were more frequently infected by Candida. Non-haematological neoplasia and pneumonia as basic diseases more often appeared in cases of candidosis. All eight immature aborted fetuses and premature infants suffered from candidosis. The survey confirms the importance of autopsy as a tool for education and quality control in medical diagnostic and therapeutic activity in the field of mycoses, too.

10.1111/j.1439-0507.2005.01101.x

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Citations (42)

Allelic loss, MIB-1 labeling index and HPV-DNA as supportive diagnostic markers in epithelial hyperplasticlaryngeal lesions

Pathology - Research and Practice (2004)

Britta Kleist D. Junghans G Lorenz Micaela Poetsch

10.1016/s0344-0338(04)80510-7

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Traumatische Trommelfellperforationen

Holger Kaftan W. Hosemann D. Junghans Achim Göpferich Ehrenfried Schindler

10.1007/s00106-004-1126-9

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Citations (14)

Cyclization of 4‐Phenylthiosemicarbazide with Phenacylbromide Revisited. Formation of 1,3,4‐Thiadiazines and of Isomeric 1,3‐Thiazoles

Journal of Heterocyclic Chemistry (2013)

W.‐D. Pfeiffer D. Junghans Ashot S. Saghyan Peter Langer

The cyclization of 4‐phenylthiosemicarbazide with phenacylbromide, carried out in refluxing ethanol, afforded 1,3,4‐thiadiazine 1 as the major product. In contrast to a previous report, 2‐phenylimino‐4‐phenyl‐2,3‐dihydro‐1,3‐thiazol‐3‐amine ( 2 ) and not 2‐hydrazono‐3,4‐diphenyl‐2,3‐dihydro‐1,3‐thiazole ( 8 ) was formed as a side‐product. This product is the main product when the reaction is carried out in concentrated hydrochloric acid. Our findings were independently confirmed by independent syntheses of the isomeric products and by a thorough study of their reactivity. It is important to note that the product distribution of the cyclization of thiosemicarbazides with haloketones strongly depends on the substitution pattern and on the reaction conditions.

Thiazole

Hydrochloric acid

Reactivity

10.1002/jhet.2007

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Citations (10)

Frequency of mycoses in autopsy material

Pathology - Research and Practice (2004)

D. Junghans G Schwesinger G Lorenz H Bernhardt M Knoke

Histopathological examination

10.1016/s0344-0338(04)80704-0

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