Iwona Ostaszewska-Puchalska

Higher School of Agribusiness

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B Zdrodowska-Stefanow

Medical University of Białystok

K Puciło

University Clinical Hospital In Bialystok

Marta Wilkowska-Trojniel

Jerzy Badyda

MultiMedica

Violetta Bułhak-Kozioł

University Clinical Hospital In Bialystok

Rościsław Bielecki

Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego

Zofia Galewska

Medical University of Białystok

M Baltaziak

Medical University of Białystok

Beata Kotowicz

The Maria Sklodowska-Curie National Research Institute of Oncology

Marianna Sokołowska

University Clinical Hospital In Bialystok

Cooperative Institutions

Medical University of Białystok

University Clinical Hospital In Bialystok

Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego

Centrum Onkologii

University of Białystok

Weatherford College

Jagiellonian University

Centralny Szpital Kliniczny

Asklepios Klinik Altona

Institute of Molecular Pathology and Pathomorphology

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Chlamydia trachomatis infections in women with adverse pregnancy outcome.

PubMed (2005)

Iwona Ostaszewska-Puchalska Marta Wilkowska-Trojniel B Zdrodowska-Stefanow Paweł Knapp

The aim of the study was to evaluate the prevalence of Chlamydia trachomatis (C. trachomatis) infection in women with adverse pregnancy outcomes.258 patients aged 18-43 yrs were enrolled into the study. Among them, 162 women have had spontaneous abortions in the past (group A), 81 had history of intrauterine death of the foetus (group B) and 15 women had experienced preterm deliveries (group C). The control group (group D) included 131 women who were in the second or third trimester of uncomplicated pregnancy. C. trachomatis was investigated in cervical and urethral smears using direct immunofluorescence or Ligase chain reaction (LCR) for direct testing and immunoenzymatic assay (EIA) for serological testing and detection of specific IgG antibodies.C. trachomatis was detected in 25.9% patients in group A, 35.8% in group B and 20% in group C and only in 12.7% in group D. IgG specific antibodies were present in 31.5%, 41.9%, 26.6% and 14.5% of patients in these groups respectively. The highest prevalence of chlamydial infections, regardless the diagnostic method used, was registered in the group of women with a history of 3 abortions (42.3% when direct testing and 45.5% when serological testing) while the lowest prevalence was in women who experienced only l abortion (23.2% and 28%).C. trachomatis infection in pregnancy affects its duration as it can lead to miscarriage, death of the foetus and preterm delivery.

Ligase chain reaction

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Subclinical prostatic inflammation attributable to Chlamydia trachomatis in a patient with prostate cancer.

PubMed (2005)

Rościsław Bielecki B Zdrodowska-Stefanow Iwona Ostaszewska-Puchalska M Baltaziak Robert Kozłowski

Chronic inflammation has long been linked to cancers with an infectious etiology. Subclinical intraprostatic inflammation is a frequent finding in prostatic specimens obtained during surgical procedures. Recent studies using biomolecular (amplification) methods showed that the incidence of cryptic bacterial infections of prostate gland may be underestimated. We present the case of 66 years old man with no symptoms of prostatitis in whom chronic Chlamydia trachomatis infection was diagnosed based on the patient's medical history and detection of chlamydial DNA in prostate biopsy specimen by means of ligase chain reaction. Two years later the patient was diagnosed with prostate cancer on repeated prostate biopsy.

Subclinical infection

Ligase chain reaction

Prostate biopsy

Etiology

Prostatic Diseases

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Mycoplasma hominis and Ureaplasma urealyticum infections in male urethritis and its complications.

Advances in Medical Sciences (2006)

B Zdrodowska-Stefanow Wioletta Marta Kłosowska Iwona Ostaszewska-Puchalska Violetta Bułhak-Kozioł Beata Kotowicz

Ureaplasma urealyticum

Mycoplasma hominis

Dysuria

Cervicitis

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The effect of Chlamydia trachomatis infection of the prostate gland on the concentration of citric acid

Archivum Immunologiae et Therapiae Experimentalis (2006)

B Zdrodowska-Stefanow Iwona Ostaszewska-Puchalska Jerzy Badyda Zofia Galewska

10.1007/s00005-006-0009-z

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Ureaplasma urealyticum and Mycoplasma hominis infection in women with urogenital diseases.

PubMed (2006)

B Zdrodowska-Stefanow Kłosowska Wm Iwona Ostaszewska-Puchalska Bułhak-Kozioł Beata Kotowicz

Ureaplasma urealyticum

Mycoplasma hominis

Outpatient clinic

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[Role of Chlamydia trachomatis infection in the pathology of male urogenital tract].

PubMed (2004)

Rościsław Bielecki B Zdrodowska-Stefanow Iwona Ostaszewska-Puchalska Robert Kozłowski K Puciło

Based on literature data, the authors have presented the informations on epidemiology, pathogenesis, clinical picture, diagnostics and treatment of Chlamydia trachomatis urogenital infections in men.

Chlamydia trachomatis infection

Chlamydial infection

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Incidence of Chlamydia trachomatis infection in patients with reactive arthritis

Reumatologia/Rheumatology (2015)

Iwona Ostaszewska-Puchalska B Zdrodowska-Stefanow Anna Kuryliszyn-Moskal Violetta Bułhak-Kozioł Marianna Sokołowska

Objectives: The aim of the study was to evaluate the incidence of Chlamydia trachomatis in patients with reactive arthritis (ReA) within the area of the Podlaskie province (north eastern Poland). Material and methods: The study concerned 323 patients including 132 women and 191 men diagnosed with ReA. The material for C. trachomatis was collected from the urethra in men and the cervical canal in women. Also, every patient was tested for the presence of anti-C. trachomatis IgG class antibodies, while 121 individuals were additionally tested for IgA class antibodies. In the direct studies, the direct immunofluorescence (DIF) method or polymerase chain reaction (PCR) was used. The immunoenzymatic method was used to detect anti-C. trachomatis antibodies. The control group in the case of direct studies comprised 125 individuals, while in the case of serology research it included 127 (IgG) and 109 (IgA) persons. Results: Chlamydia trachomatis infection in the urethral and cervical smears was found in 42 patients (13.0%) including 20 women (15.2%) and 22 men (11.5%). In the control group chlamydia was detected in 3 patients (2.4%) including 4% of women and 2% of men. IgA class antibodies were present in 10/121 (8.3%) patients, similarly in women and in men (8.2% and 8.3% respectively). In the control group the specific IgA class antibodies were found in 3/85 patients (3.5%). Anti-C. trachomatis IgG antibodies were found in 70/323 patients (21.7%), similarly in men and women. Conclusions: 1. Chlamydia trachomatis is a common bacterial factor observed in the genitourinary system of patients with ReA. The outcomes of studies within the Podlaskie province indicate less frequent presence of chlamydial infection compared with Dolnośląskie province. 2. No correlations between detecting the presence of C. trachomatis in the urogenital tract and the presence of specific antibodies in the serum of ReA patients were observed. 3. Concurrent direct studies of the urogenital tract and a serological blood test increase the chance of detecting C. trachomatis infection.

10.5114/reum.2015.51505

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Oculogenital Chlamydia trachomatis infections in adults

Iwona Ostaszewska-Puchalska B Zdrodowska-Stefanow K Puciło

The aim of the research was to determine the prevalence of C. trachomatis (C.t.) conjunctivitis and urogenital infections coexistence in adults. The study was carried out on 222 patients (109 women and 113 men) with clinical signs of conjunctivitis. Conjunctival swabs were taken from all patients for evaluation and urogenital swabs as well as blood from the patients with confirmed infection. Direct diagnostics of chlamydial infections involved IF and LCR methods while serologic diagnostics (specific IgG antibodies) used EIA and indirect IF methods. The control group for conjunctival swabs included 52 volunteers who did not have any ophthalmological symptoms while for the serological tests the control group consisted of 103 blood donors. Ocular C.t. infection was diagnosed in 42 out of 222 (18.9%) patients with conjunctivitis symptoms and in 2 out of 52 (3.8%) patients of the control group. Chlamydial conjunctivitis was mostly (70%) found in young people (18-30 yrs) and it was twice more common in women. It was usually bilateral and chronic. Urogenital C.t. infection was diagnosed in 24 out of 42 (57.1%) patients and it was more common in men (14 patients) than in women (10 patients). Only 4 out of 42 (9.5%) patients suffered from any urogenital symptoms. Specific IgG antibodies were found in the serum of 29 out of 42 (69%) patients with chlamydial conjunctivitis and only in 6 out of 103 (5.8%) patients of the control group. The diagnostics of the ocular infections, which are resistant to routine treatment, should involve the consideration of etiological role of C.t. Due to common urogenital chlamydial infection coexistence both sexual partners should be diagnosed and treated.

Chlamydial infection

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Antichlamydial antibodies and citric acid in patients with chronic prostatitis

Archivum Immunologiae et Therapiae Experimentalis (2007)

Iwona Ostaszewska-Puchalska B Zdrodowska-Stefanow Jerzy Badyda Zofia Galewska

The aim of the study was to evaluate the correlation between the presence of anti-C. trachomatis (C.t.) antibodies in serum and expressed prostatic secretions (EPS) and the concentration of citric acid in patients with chronic prostatitis. The study involved 34 men with chronic prostatitis. The leukocyte count, presence of anti-C.t. antibodies (IgA, IgG), and citric acid concentration were determined in the EPS. The serum was examined for IgM, IgA, and IgG anti-C.t. antibodies. Specific antibodies were determined using the EIA method. The concentration of citric acid was measured using the ultraviolet method. Inflammation of the prostate (≥10 PMN) was found in 61.8% of the patients. A reduction in citric acid concentration in the EPS was detected in 58.8% of the men. Specific serum antibodies were detected in 58.8% of the patients, including 23.5% with IgM, 32.4% with IgA, and 44.1% with IgG. In all patients, serum IgM and IgA antibody titers were low, while those of IgG antibodies were strongly positive in 46.7% of the patients. Anti-C.t. antibodies in the EPS were detected in 44.1% of the patients, including 32.4% with IgA and 35.3% with IgG. In contrast to serum, the titers of IgG antibodies in the EPS were low in all the patients, while those of IgA were strongly positive in 54.5% of cases. In patients with positive serological outcomes, 85% had reduced concentrations of citric acid. The occurrence of anti-C.t. antibodies is usually accompanied by a decrease in the concentration of citric acid in the prostatic secretion.

Immunoglobulin A

10.1007/s00005-007-0006-x

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Citations (4)

Prevalence of Chlamydia trachomatis infection in women with cervical lesions.

PubMed (2007)

Violetta Bułhak-Kozioł B Zdrodowska-Stefanow Iwona Ostaszewska-Puchalska Beata Maćkowiak-Matejczyk T M Pietrewicz

Cervicitis

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Citations (9)