Superfine ground calcium carbonate (GCC) produced by carbonate minerals is a widely used inorganic powder material. In order to get a finer GCC powder with narrow distribution span, the effect of rotational speed and media density on ground GCC were studied by dry grinding GCC in a planetary ball mill under different rotational speed and various media density. The grinding limit-particle size and distribution of grinding calcium carbonate were measured by centrifugal sedimentation granulometer. The structure of GCC was measured by X-ray diffraction. The result shows that low rotational speed and high-density media is conducive to get a product with smaller particle size and narrow size distribution; crystal plane (012) and (122) are more stable than (018) and (116).
ABSTRACT Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, particularly among complex high‐risk and indicated patients (CHIP). Revascularization is often beneficial for these patients; however, it requires thorough risk stratification and close multidisciplinary collaboration between cardiologists and cardiac surgeons to optimize outcomes. Personalized treatment plans, including percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), are crucial in this context. In this report, we present a case of a 70‐year‐old man with left main trunk bifurcation lesions, referred to as a “Four Forks Lesion,” who was successfully revascularized using a PCI strategy, resulting in a favorable prognosis.
Abstract Melanoma, the most aggressive skin cancer type, is challenging to treat due to its high metastatic potential and low response to conventional therapies. Innovative approaches, including combination therapies, are crucial for enhancing treatment efficacy while minimizing side effects. It is developed boronophenylalanine‐containing polydopaine (B‐PDA) nanoparticles by encapsulating boronophenylalanine in polydopamine through nitrogen‐boronate coordination, targeting both boron neutron capture therapy (BNCT) and photothermal therapy (PTT). With stability and biocompatibility under physiological conditions, these nanoparticles utilize the phenylalanine residues in BPA to target the overexpressed neutral amino acid transporter 1 (LAT1) in melanoma cells, resulting in enhanced cell‐specific targeting. B‐PDA nanoparticles demonstrated significant photothermal effects under external stimulation, inducing localized heating and triggering heterogeneous tumor cell death, thereby enhancing sensitivity to BNCT. Combining BNCT and PTT, the B‐PDA nanoparticles offer a promising strategy for melanoma treatment.
Smart healthcare sensor (SHS) belongs to a kind of patient-centered diagnostics, which highly revolutionizes traditional healthcare service and attracts great attention. However, widespread application of currently-reported SHS is severely limited due to non-ideal mechanical/electrical self-healing performance, too robust or weak skin-adhesion strength, and poor water resistance. A novel film-based SHS that composed of poly(3-hexylthiophene-2, 5-diyl)/butyl rubber (P3HT/BR), eutectic Gallium-Indium (E-GaIn), and polydimethylsiloxane-P3HT/BR (P-P3HT/BR) was proposed herein and employed for high-performance electrocardiogram (ECG) and electromyogram (EMG) monitoring. Specifically, viscosity characteristic and low glass transition temperature of BR, hooked chains of P3HT, and encapsulated E-GaIn jointly endowed the SHS with high self-healing efficiencies of 79.61%± 5.60% and 90.17% ± 3.76% to repair mechanical and electrical breakdowns autonomously, respectively. Meanwhile, skin adhesion mechanism of the SHS was mainly relied on mechanical friction caused by meshing force, thus resulting in a moderate adhesion or painless detachment with a skin-adhesion strength of 7.00 ± 0.70 kPa. More interestingly, extensive experimental results performed in pigs and humans demonstrated that the SHS achieved ECG and EMG monitoring with high accuracy and stable sensitivity underwater due to the designed hydrophilic/hydrophobic Janus surface. Overall, the as-fabricated SHS provided an outstanding biopotential monitoring and paved an ascendant way toward personalized healthcare in the new era.
Hydrogen peroxide reacts with V4+ on (011) exposed facet of 2D Zn3V3O8 nanosheets to produce a hydroxyl radical via a Fenton-like reaction and its peroxidase-like activity is applied to glucose colorimetric detection.
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