Christina Antza

Papageorgiou General Hospital

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i-10 index

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Vasilios Kotsis

Papageorgiou General Hospital

133

Stella Stabouli

Aristotle University of Thessaloniki

Ioannis Doundoulakis

National and Kapodistrian University of Athens

Christos V. Rizos

University of Ioannina

Evangelos Liberopoulos

National and Kapodistrian University of Athens

ΚΤ

Κωνσταντίνος Τζιόμαλος

Aristotle University of Thessaloniki

Ioannis Skoumas

National and Kapodistrian University of Athens

Genovefa Kolovou

Onassis Cardiac Surgery Center

E. Zacharis

University Hospital of Heraklion

Lοukianos S. Rallidis

National and Kapodistrian University of Athens

Cooperative Institutions

European Atherosclerosis Society

623

Aristotle University of Thessaloniki

124

National and Kapodistrian University of Athens

Inserm

Papageorgiou General Hospital

Hippocration General Hospital

AHEPA University Hospital

Ippokrateio General Hospital of Thessaloniki

University College London

Ospedale Policlinico San Martino

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Exploring the correlation between triglyceride levels and atherosclerotic cardiovascular disease prevalence in adults with familial hypercholesterolemia: Insights from a cross-sectional analysis in the HELLAS-FH registry

Journal of clinical lipidology (2025)

Panagiotis Anagnostis Christos V. Rizos Georgé Liamis Lοukianos S. Rallidis Ioannis Skoumas

Cross-sectional study

Atherosclerotic cardiovascular disease

10.1016/j.jacl.2024.12.017

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Coexistence of cardiovascular risk factors in patients with familial hypercholesterolemia: Data from the HELLAS-FH registry

Atherosclerosis (2020)

Christos V. Rizos Moses Elisaf Ioannis Skoumas Lοukianos S. Rallidis Κωνσταντίνος Τζιόμαλος

Atherosclerotic cardiovascular disease

10.1016/j.atherosclerosis.2020.10.660

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Comparison of the SphygmoCor XCEL device with applanation tonometry for pulse wave velocity and central blood pressure assessment in youth

Journal of Hypertension (2018)

Stella Stabouli Nikoleta Printza C. Zervas John Dotis Katerina Chrysaidou

Vascular phenotype by assessing carotid-femoral pulse wave velocity (cf-PWV) and central SBP (cSP) in the young could be used as an intermediate cardiovascular outcome measure. Tonometry is considered the gold-standard technique, but its use is challenging in clinical practice, especially when used in children. The purpose of this study was to validate cf-PWV and cSP assessment with novel oscillometric device (SphygmoCor XCEL) in children and adolescents.cf-PWV and cSP were measured in 72 children and adolescents aged 6-20 years. Measurements were performed by applanation tonometry and by the SphygmoCor XCEL device at the same visit under standardized conditions. Regression analysis and Bland-Altman plots were used for comparison of the tonometer-based with oscillometric-based method.Mean cf-PWV measured by applanation tonometry was 4.85 ± 0.81 m/s and measured by SpygmoCor XCEL was 4.75 ± 0.81 m/s. The mean difference between the two devices was 0.09 ± 0.47 m/s (P = NS). cSP measured by SpygmoCor XCEL was strongly correlated with cSP measured by applanation tonometry (R = 0.87, P < 0.001). Mean cSP measured by applanation tonometry was 103.23 ± 9.43 mmHg and measured by SpygmoCor XCEL was 103.54 ± 8.87 mmHg. The mean cSP difference between the two devices was -0.30 ± 3.34 mmHg (P = NS), and fulfilled the AAMI criterion 1. The estimated intersubject variability was 2.17 mmHg.The new oscillometric SphygmoCor XCEL device provides equivalent results for cf-PWV and cSP values to those obtained by tonometry in children and adolescents. Thus, the SphygmoCor XCEL device could be appropriate for assessing cf-PWV and cSP in the pediatric population.

Applanation tonometry

Pulse Wave Analysis

Mean difference

10.1097/hjh.0000000000001819

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EXTERNAL VALIDATION STUDY OF THE EARLY VASCULAR AGING AMBULATORY SCORE (EVAAS)

Journal of Hypertension (2021)

Christina Antza Ioannis Doundoulakis Evangelos Akribos Stella Stabouli Vasilios Kotsis

Objective: The Early Vascular Aging Ambulatory score (EVVAs) identify hypertensive patients with Early Vascular Aging using ambulatory blood pressure monitoring values and classic cardiovascular risk factors. Our aim was to validate the EVAAs externally in a new population-based cohort study. Design and method: This cohort study included all consecutive patients (N = 789, 45.87 ± 23.27, 45.4% men), who referred to the Hypertension-24hour Ambulatory Blood Pressure Monitoring Center of Excellence, at the 3rd Internal Medicine Department of Aristotle University for elevated BP and consented to participate to the study. Carotid-femoral pulse wave velocity (c-f PWV) was measured in all patients. EVA was defined as c-f PWV values higher than the expected for age average values according to European population data. We evaluated the predictive power of the original EVVAs. Results: The calculated sensitivity and specificity for EVAAS was 98% and 75% respectively. The EVVAs has a high positive predictive value (PPV) of 95%. The negative predictive value (NPV) was slightly lower at 92%. Receiver operating characteristic curve, including the area under the curve, was 0.951 which indicates a very high accuracy. Conclusions: The external validation of the EVVAs yields high sensitivity and PPV in an independent population. The EVAAs should now be evaluated for its predictive value regarding cardiovascular mortality and morbidity. Finally, the prediction of EVA, assessed by EVAAs, could be used to guide early lifestyle or pharmaceutical interventions in order to prevent future CV events.

10.1097/01.hjh.0000745360.75696.5e

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A gut feeling about children’s exposure to hypertensive disorders of pregnancy in utero

European Journal of Preventive Cardiology (2019)

Ioannis Doundoulakis Christina Antza Vasilios Kotsis George Giannakoulas

10.1177/2047487319857213

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P5324Children with familial hypercholesterolemia: lipid profile, treatment and evaluation of different formulas for calculating low-density lipoprotein cholesterol: an analysis from the HELLAS-FH registry

European Heart Journal (2019)

Evangelos Liberopoulos Christos V. Rizos Anastasia Garoufi Genovefa Kolovou Vasilios G. Athyros

Abstract Introduction There is limited data on cardiometabolic characteristics and treatment of underage patients with familial hypercholesterolemia (FH). Accurate estimation of low-density lipoprotein cholesterol is essential to tailor hypolipidemic treatment. Purpose To report lipid profile and current treatment of underage patients with FH in Greece as recorded in the HELLAS-FH registry. Also, to compare the Friedewald with the Martin/Hopkins equation, (which provides a customized estimation of VLDL-C) and the Dahlen's formula [(which adjusts the LDL-C measurements for the amount of cholesterol in Lp(a)]. Methods Underage patients with FH were evaluated. Lipid profile, current treatment regimen as well as LDL-C levels as assessed with different formulas were evaluated. Results A total of 191 children were included (51.0% boys, 11.0±3.5 years old). Children at baseline had mean LDL-C as calculated by the Friedewald equation (LDL-CF) 233±65 mg/dL and median Lp(a) 15.3 (IQR 8–51) mg/dL. A total of 59.2% of subjects were receiving hypolipidemic treatment, mainly statins (29.4%) and sterols/stanols (25.5%). Children on hypolipidemic therapy had mean LDL-CF 183±98 mg/dL with 22.1% achieving an LDL-C≤130 mg/dL. When LDL-C was calculated based on the Martin-Hopkins equation (LDL-CM/H) respective values were 180±58 mg/dL and 24.8%. When LDL-C was corrected for Lp(a) [= LDL-CM/H − (Lp(a) * 0.30)], LDL-C was 174±105 mg/dL with 33.3% of patients within the LDL-C target. Conclusions Nearly two-thirds of children were receiving some kind of hypolipidemic treatment at the time of registration. For those on treatment, LDL-C goal is achieved by one in five, which rises to 1 in 3 when LDL-C is corrected for Lp(a) levels.

Lipid Profile

Regimen

Low-density lipoprotein

10.1093/eurheartj/ehz746.0293

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LDL levels as a predictor of arterial stiffness: A cross-sectional study

Atherosclerosis (2017)

Christina Antza Ioannis Doundoulakis S. Stabouli Vasilios Kotsis

Cross-sectional study

10.1016/j.atherosclerosis.2017.06.179

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Obesity and cardiovascular risk

Journal of Hypertension (2018)

Vasilios Kotsis Jens Jordan Dragan Micić Nick Finer Deborah R. Leitner

Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications. Epidemiology and mechanisms of obesity-induced hypertension, diabetes and dyslipidemia will be reviewed and the role of lifestyle modification and treatment strategies in obesity will be updated and analyzed. The best treatment options for people with obesity, hypertension, diabetes and dyslipidemia will discussed.

Dyslipidemia

Stroke

10.1097/hjh.0000000000001730

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Citations (103)

Overweight/obesity and prevalent atherosclerotic cardiovascular disease in patients with heterozygous familial hypercholesterolemia: An analysis from HELLAS-FH registry

Atherosclerosis (2023)

Fotios Barkas Christos V. Rizos Georgé Liamis Ioannis Skoumas Anastasia Garoufi

Stroke

10.1016/j.atherosclerosis.2023.06.849

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Comparison of validation protocols for blood pressure measuring devices in children and adolescents

Frontiers in Cardiovascular Medicine (2022)

Stella Stabouli Athanasia Chainoglou Kleo Evripidou Carla Simão Christina Antza

Accuracy of blood pressure (BP) measurement is important for the evaluation of hypertension in children and adolescents, and it is critically dependent upon the accuracy of the BP measuring device. A device that could pass validated protocols with reliable accuracy would be desirable in clinical and research settings. Several scientific organizations have published recommendations on the validation of different BP measuring devices. Most of them focus on adults but separate recommendations and validation criteria for BP devices intended for use in children and adolescents are included in some validation protocols. In this review, we compare the validation criteria for BP measuring devices among consensus documents from different scientific organizations focusing on the pediatric population and we discuss the evidence gaps targeting the needs for validated BP measuring devices in children and adolescents. We also highlight common pitfalls in the validation studies of BP measuring devices in children and adolescents using the example of office BP devices.

10.3389/fcvm.2022.1001878

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Citations (5)