Pramod Kadu

Shri Vile Parle Kelavani Mandal

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Pravin Popatrao Kale

Shri Vile Parle Kelavani Mandal

Kedar S. Prabhavalkar

Shri Vile Parle Kelavani Mandal

Bhakti Sawant

Shri Vile Parle Kelavani Mandal

Mirza Ilyas Rahim Baig

University of Mumbai

Ruchita Ravindra Dhangar

Shri Vile Parle Kelavani Mandal

Santosh Yele

Narsee Monjee Institute of Management Studies

Pradip Bawane

Shri Vile Parle Kelavani Mandal

Tanwi Choche

Tanvi Parmar

Shri Vile Parle Kelavani Mandal

Janhavi Naik

Vishwakarma University

Cooperative Institutions

Shri Vile Parle Kelavani Mandal

Narsee Monjee Institute of Management Studies

University of Mumbai

Rashtrasant Tukadoji Maharaj Nagpur University

Vishwakarma University

Helios Hospital Berlin-Buch

Charité - Universitätsmedizin Berlin

National Institute of Pharmaceutical Education and Research

Indian Institute of Technology Bhilai

United Arab Emirates University

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Formulation and evaluation of clarithromycin gastroretentive dosage form

Journal of chemical and pharmaceutical research (2014)

Dheeraj L. Patingrao Pramod Kadu

Floating matrix tablets of clarithromycin were developed to prolonged gastric residence time and thereby increase drug availability. The tablets were formulated by wet granulation technique, using polymers such as Guar Gum, HPMC-K15M and HPMC-K100M, and other standard excipient. Tablets were evaluated for physical characteristics viz, hardness, percentage friability, floating capacity, weight variation and content uniformity. Further, tablets were evaluated for in-vitro release characteristics for 12hr. Increasing the polymer ratio the FLT was increase but the drug release was decreased.

Friability

Granulation

Guar gum

Excipient

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Citations (3)

Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice

Neurology Research International (2018)

Jegan Sakthivel Nadar Pravin Popatrao Kale Pramod Kadu Kedar S. Prabhavalkar Ruchita Ravindra Dhangar

Hesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT 1 /MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depression because of its dopamine and norepinephrine reuptake inhibition. The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, ‘hesperidin alone’, ‘agomelatine alone’, hesperidin+agomelatine, ‘bupropion alone’, hesperidin+bupropion, and agomelatine+bupropion for 14 days. The immobility period was analysed 30 min after the treatment in forced swim and tail suspension tests. Dopamine and serotonin levels were analysed in hippocampus, cerebral cortex, and whole brain using HPLC with fluorescence detector. Hesperidin plus agomelatine treated group was better in terms of decrease in immobility period and increase in dopamine and serotonin levels when compared to their respective monotherapy treated groups.

Bupropion

Agomelatine

10.1155/2018/9828639

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Citations (14)

Assessment of antidiabetic activity of combination of Murraya koenigii leaves extract and Vitis vinifera seeds extract in alloxan-induced diabetic rats

Journal of Reports in Pharmaceutical Sciences (2020)

Pravin Popatrao Kale ShreyaM Palwankar Pramod Kadu Kedar S. Prabhavalkar

Background: Murraya koenigii is a well-known curry leaf tree. Its leaves are used as a spice in food recipe in India. Its related antidiabetic activity is attributed to alpha glucosidase activity of carbazole alkaloids. The proanthocyanidins present in Vitis vinifera contribute to its hyperglycemic activity through antioxidant effect and preservation of β-cell function. Aims and Objective: The aim of this study was to assess antidiabetic effect of the combination of M. koenigii leaves extract and V. vinifera seeds extract. Materials and Methods: A total of 36 animals were randomly selected for the study and were divided in six different groups: control group, alloxan (130 mg/kg; intraperitoneal [i.p.]) treated group, alloxan (130 mg/kg) treatment + M. koenigii leaves extract (300 mg/kg; per oral [p.o.]) treated group, alloxan (130 mg/kg) i.p. treatment + V. vinifera seeds extract (200 mg/kg; p.o.) treated group, alloxan (130 mg/kg) + M. koenigii leaves extract (150 mg/kg; p.o.) treatment + V. vinifera seeds extract (100 mg/kg; p.o.) treated group, and alloxan (130 mg/kg) treatment + glibenclamide (5 mg/kg; i.p.) treated group. Treatment was given for 21 days after induction of diabetes. Result: The combination treated group showed a significant reduction in serum glucose levels when compared to individual test extracts. It also attenuated the elevated activity of alkaline phosphatase enzyme in diabetic rats as compared with the healthy controls. The combination treatment showed reversal of the serum glutamic oxaloacetic transaminase (P < 0.001) and serum glutamic pyruvic transaminase (P < 0.001) levels. It also significantly decreased cholesterol level to near normalcy (P < 0.001). Conclusion: The findings of this study suggest additive antidiabetic effect of the combination of M. koenigii leaves extract and V. vinifera seeds extract.

Alloxan

Murraya

Transaminase

Phytotherapy

10.4103/jrptps.jrptps_50_19

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Citations (6)

Use of In silico tools for screening buffers to overcome physical instability of Abatacept

Transplant Immunology (2022)

Janhavi Naik Duttraj Kulkarni Pramod Kadu Aditya Pandya Pravin Popatrao Kale

Abatacept

Docking (animal)

Deamidation

Buffer (optical fiber)

10.1016/j.trim.2022.101551

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Citations (1)

Copper-lowering agents as an adjuvant in chemotherapy

Indian Journal of Pharmacology (2021)

Pramod Kadu Bhakti Sawant Pravin Popatrao Kale Kedar S. Prabhavalkar

Copper is an important element essential for metabolism and normal human body function. Although it is an essential element, related imbalance leads to toxic effects. Studies have proved that there is an increase in copper level in cancer cells. Evidences suggest the link between increase in copper levels and progression of various types of cancers. Different strategies have been utilized to decrease the level of copper in various types of cancer cells. However, it was observed that cell machinery involved in copper homeostasis plays critical factor in lowering copper levels in cancer cells. The outcomes of many monotherapies consisting copper-lowering agents for the treatment of different types of cancers showed that the inhibition of single factor is not sufficient to inhibit the growth of cancer cells. The combination of copper-lowering agent with chemotherapeutic agent showed synergistic effect. Interestingly, the presence of copper-lowering agent in such combinations significantly improved the efficacy of chemotherapeutic agent. The present work has focused on the discussion of outcomes of studies involving anti-copper agent and chemotherapeutic agent and related future strategies.

Cancer Chemotherapy

Homeostasis

10.4103/ijp.ijp_68_20

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Citations (9)

Copper-lowering agents as an adjuvant in chemotherapy.

Pramod Kadu Bhakti Sawant Pravin Popatrao Kale Kedar S. Prabhavalkar

Cancer Chemotherapy

Homeostasis

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Citations (4)

Mechanisms of emerging resistance associated with non-antibiotic antimicrobial agents: a state-of-the-art review

The Journal of Antibiotics (2023)

Mirza Ilyas Rahim Baig Pramod Kadu Pradip Bawane Kartik T. Nakhate Santosh Yele

Efflux

Biocide

Anti-Infective Agents

10.1038/s41429-023-00649-4

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Citations (13)

Self-emulsifying Drug Delivery System of Rosuvastatin Calcium

International Journal of Pharmacy (2017)

Madhura Mestry Meenal Rane Pramod Kadu Snehal More

Running title: Self-emulsifying drug delivery system of Rosuvastatin Calcium. Introduction: Oral route is the preferred route for higher patient compliance. Rosuvastatin Calcium is BCS class II drug and its oral bioavailability is 20%. To overcome this problem, studies were performed to enhance the solubility of the Rosuvastatin Calcium in order to improve the bioavailability. Materials and methods: Different permutations and combinations of oils such as Castor oil, Cottonseed oil, Olive oil, Soyabean oil, Olyl alcohol, Peceol, Rice bran and Sunflower oil, surfactants Tween 20, Tween 80, Kollisolve PEG 400, Cremophore RH 40, Cremophore EL and co-surfactants PEG 200, PEG 400, Transcutol HP were tried in order to deduce the compatible oils and (co)surfactants to prepare pseudo-ternary phase diagram. Results and discussion: The optimized batch of Rosuvastatin Calcium SEDDS was prepared using Peceol (10%), Tween-20 (30%) and Transcutol (30%) having average particle size 76.88nm, polydispersibility index 0.555 and zeta potential of -24.5 mV. In addition, drug entrapment in the optimized batch was found to be 95.89%. The stability studies data of 3 months shows that the emulsion was stable for at least 3 months with drug entrapment 91.60 ± 0.02%. The formulation showed approximately 95% drug release within 15 min as compared to the pure drug, which showed drug release of 36.56% in phosphate buffer pH 6.8. Conclusion: From the above study, it can be concluded that SEDDs can be a promising approach to improve the solubility and in order to improve the oral bioavailability of Rosuvastatin Calcium.

Rosuvastatin Calcium

PEG 400

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Citations (1)

FORMULATION AND EVALUATION OF NOVEL ANTI-BACTERIAL CIPROFLOXACIN LOADED NIOSOMAL CREAM

International Research Journal of Pharmacy (2015)

Vishal Suresh Rokade Pramod Kadu

The development of Ciprofloxacin loaded niosomes using combination of Span-60 and Lipotin A, to increase the local effect of Ciprofloxacin on the bacterial infected skin.Ciprofloxacin encapsulated niosomes were formulated by thin film hydration technique using rotary vacuum evaporator and were incorporated into cream base.The formulation was optimized by changing the ratio of Span 60 and Lipotin A, based on maximum entrapment efficiency and drug retention using ex-vivo drug diffusion study.The selected optimized formulation was subjected to in-vitro study and antibacterial activity study which was compared with the conventional Ciprofloxacin cream.Ciprofloxacin loaded Niosomal cream with 70-90% entrapment efficiency was successfully developed using combination of span60 as non-ionic surfactant and Lipotin A as a dispersing agent.The optimized Ciprofloxacin loaded niosomal cream was found to show maximum drug retention with 71.49% within 12 hours, which has been require for local effect.It also provided more antibacterial activity and sustained release of drug by in-vitro study with 46.22% diffusion within 8 hours, as compared to conventional Ciprofloxacin cream.Thus, the developed Ciprofloxacin loaded niosomal cream was considered to be an enhanced topical delivery of ciprofloxacin through skin with sustained action, with maximum retention for prolong effect and thereby, providing successful local treatment of various bacterial skin infections.

10.7897/2230-8407.068104

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Citations (8)

Critical Strategies for Drug Precipitation Inhibition: A Review with the Focus on Poorly Soluble Drugs

Current Drug Delivery (2022)

Pramod Kadu Tanvi Parmar Pravin Popatrao Kale

An oral route for drug administration is a more suitable route because of its ease of administration, pain avoidance, patient compliance, accommodation of various types of drug molecules, etc. But there are many factors affecting the oral absorption of the drugs. The main factor associated with oral absorption is drug solubility. Many new chemical molecules are poorly soluble in nature and can be included in BCS classes II and IV. For the administration of these drugs through the oral route, it was found that solubility is the rate limiting step. The low solubility of these drugs tends to cause precipitation in the gastrointestinaltract (GIT), affecting their bioavailability. Drug precipitation may be triggered by many factors such as insolubility of the drug in co-solvent, drug-excipient interactions, physiochemical properties of the drug, sudden change in the pH of the environment, incompatibility with the surfactant, etc. Precipitation of a drug may occur in two stages, formation of nucleation and crystal growth. To overcome precipitation, there are many strategies such as the use of polymers, the addition of surfactants, modulating drug loading and solubilizing capacity, change in the pH of the environment, etc. In this review, the causes of precipitation and diverse strategies of precipitation inhibition are critically reviewed.

10.2174/1567201819666220427123101

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Citations (1)