Mohamed Samir

Cairo University

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Frank Peßler

Center for Experimental and Clinical Infection Research

Frauke Seehusen

University of Zurich

Robert Geffers

Helmholtz Centre for Infection Research

Ahmed A. H. Ali

Zagazig University

Hazem Ramadan

Mansoura University

Abdallah M. A. Merwad

Zagazig University

Fatma Abdallah

Zagazig University

Ragaa Abdelkader Ramadan

Alexandria University

Yasmine H. Tartor

Zagazig University

Eman Mostafa

Kafrelsheikh University

Cooperative Institutions

Zagazig University

Cairo University

Alexandria University

Mansoura University

All India Institute of Medical Sciences Bhopal

Benha University

Helmholtz Centre for Infection Research

Medizinische Hochschule Hannover

Menoufia University

Assiut University

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Metabolic profiling during COVID-19 infection in humans: Identification of potential biomarkers for occurrence, severity and outcomes using machine learning

PLoS ONE (2024)

Gamalat A. Elgedawy Mohamed Samir Naglaa Elabd Hala El‐Said Mohamed Enar

After its emergence in China, the coronavirus SARS-CoV-2 has swept the world, leading to global health crises with millions of deaths. COVID-19 clinical manifestations differ in severity, ranging from mild symptoms to severe disease. Although perturbation of metabolism has been reported as a part of the host response to COVID-19 infection, scarce data exist that describe stage-specific changes in host metabolites during the infection and how this could stratify patients based on severity.

Coronavirus

2019-20 coronavirus outbreak

10.1371/journal.pone.0302977

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Management of Shock - Recent Advances

IntechOpen eBooks (2022)

Sri Rama Ananta Padala Vaishali Waindeskar Ved Prakash Maurya Rakesh Mishra

Recent advancements have resulted in improved diagnosis and management of patients who present with shock in clinical practice. Shock can lead to decreased tissue perfusion and thus decreased oxygenation, resulting in poorer outcomes. Timely diagnosis and appropriate interventions are crucial to break the cascade of events and thus improve outcomes in patients with shock. This book presents a comprehensive overview of shock, including information on its etiology, detection, and management.

Etiology

10.5772/intechopen.100997

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Behaviour of Bone Marrow Stem Cells in Eyes of Rabbits With Chorioretinal Injuries Caused by Laser Red Diode 670nm

Rubens Camargo Siqueira Luis Emilio Abad G. K. BENSON Mohamed Samir

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Sacred Buildings and Brain Performance: The Effect of Sultan Hasan Mosque on Brain Waves of its Users

CREATIVE SPACE (2014)

Sally Essawy Basil Kamel Mohamed Samir

Which are the issues posed for the construction of a church in the urban fabric of the third millennium? Which are, currently, the places of worship -- more or less visible -- capable of attracting the faithful, not just the inhabitants but also migrants or visitors in transit? What kind of conflicts can the construction of a church, or more generally of a sanctified space, create in a neighbourhood and, which could be the conditions to avoid it? In some cases, places of worship contribute to reinforce the feeling of belonging and/or identity. They are also points of orientation in the cities, which exceed the scale of their communities, opening up to other confessions, also. They participate in urban life through many events (concerts, kermesses, theatrical plays) that we can qualify within culture. This paper interrogates the notion of sanctified space from the spatial point of view, through the analysis of the sanctified space built in Rome in the new place of urban centre, but also from the standpoint of dividual and collective representations. Between tradition and future, attractiveness and repulsion, beyond the symbolic dimension (brand) of the sanctified building, the text places the question of methodological processes that lead to the construction of a space, both real and virtual. In the final argument, the comparison between the Italian and French experiences can help to identify the differences between the two systems -- of a technical and sociological nature -- in order to identify the manner in which we can overcome the mono-functional and restrictive use of the worship sites, in favour of multi-functional uses, both internal and aggregated, thereby allow a wider ownership of these spaces, in the present era where the churches are gradually becoming more and more empty.

Worship

Argument (complex analysis)

Neighbourhood (mathematics)

The Symbolic

10.15415/cs.2014.12006

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Citations (14)

The Effect of Restoration of Lumbar Spine Lordosis During Fixation on Clinical Outcome of Patients

Zagazig University Medical Journal (2019)

abdurhman albriki adel Ismaeil Mansour Makia Mohamed Samir

Lumbar lordosis

10.21608/zumj.2019.16446.1471

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Antimicrobial Resistance, Genetic Diversity and Multilocus Sequence Typing of Escherichia coli from Humans, Retail Chicken and Ground Beef in Egypt

Pathogens (2020)

Hazem Ramadan Charlene R. Jackson Jonathan G. Frye Lari M. Hiott Mohamed Samir

Contamination of retail foods with foodborne pathogens, particularly the antimicrobial resistant ones, poses a persistent threat to human health. There is a dearth of information about the overlapping Escherichia coli (E. coli) lineages circulating among retail foods and humans in Egypt. This study aimed to determine the clonal diversity of 120 E. coli isolates from diarrheic patients (n = 32), retail chicken carcasses (n = 61) and ground beef (n = 27) from Mansoura, Egypt using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Simpson's index of diversity was calculated to compare the results of both typing methods. Antimicrobial resistance phenotypes, genotypes and phylogrouping of the isolates were also determined. Higher frequencies of antimicrobial resistance were found among chicken isolates compared to beef and human isolates; regardless of isolate source, the predominant antimicrobial resistances were found against ampicillin (87/120, 72.5%), tetracycline and sulfisoxazole (82/120, 68.3%, each), and streptomycin (79/120, 65.8%). None of the isolates displayed resistance to meropenem. The prevalent genes detected were tetA (64.2%), blaTEM (62.5%), sul1 (56.7%), floR (53.3%), sul2 (50%), strB (48.3%) and strA (47.5%) corresponding with resistance phenotypes. Alarmingly, blaCTX was detected in 63.9% (39/61) of chicken isolates. The majority of E. coli isolates from humans (90.6%), beef (81.5%) and chicken (70.5%) belonged to commensal phylogroups (A, B1, C). Using PFGE analysis, 16 out of 24 clusters (66.7%) contained isolates from different sources at a similarity level ≥75%. MLST results assigned E. coli isolates into 25, 19 and 13 sequence types (STs) from chicken, human and beef isolates, respectively. Six shared STs were identified including ST1011, ST156, ST48, ST224 (chicken and beef), ST10 (human and chicken) and ST226 (human and beef). Simpson's index of diversity was higher for MLST (0.98) than PFGE (0.94). In conclusion, the existence of common genetic determinants among isolates from retail foods and humans in Egypt as well as the circulation of shared STs indicates a possible epidemiological link with potential zoonotic hazards.

Multilocus sequence typing

10.3390/pathogens9050357

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Overexpression of miR-21-5p as a potential pathogenesis marker for ovarian endometriosis

The Journal of Basic and Applied Zoology (2025)

Mohamed E. Mahmoud Amr Ahmed WalyEldeen Mohamed Abdel samie Ahmed M. Sadek Sayed ElAkhras

Abstract Background Endometriosis is a benign gynecological disease characterized by the growth of endometrial cells beyond the uterus, forming endometriotic cyst tissues called ovarian endometriomas. MicroRNAs (miRNAs) are small, non-coding RNAs that epigenetically control the physiological and pathological processes of different diseases, including endometriosis. In this study, we screened the expression levels of 11-selected miRNAs, namely miR-21-5p, miR-200c-3p, miR-19a-3p, miR-203-3p, miR-181b-5p, miR-182-5p, miR-let7a-5p, miR-205-5p, miR-200b-3p, miR-16-5p, and miR-222-3p in ovarian endometriomas relative to eutopic endometrial tissues using quantitative real-time PCR (qPCR). In addition, the level of mRNA expression of lumican ( LUM ), an extracellular matrix proteoglycan (PG), and a putative target of miR-21-5p was quantified by qPCR. Results Our screening qPCR results showed that 9 miRNAs were upregulated (miR-21-5p, miR-200c-3p, miR-19a-3p, miR-203-3p, miR-181b-5p, miR-182-5p, miR-let7a-5p, miR-205-5p, and miR-200b-3p), whereas 2 miRNAs were downregulated (miR-16-5p and miR-222-3p) in ovarian endometriomas compared to eutopic endometrium. A significant overexpression of miR-21-5p in ovarian endometrioma was further independently verified by qPCR. Using bioinformatics tools, Gene Ontology Kyoto Encyclopedia of Genes and Genomes pathways, and protein–protein interactions, we identified differentially expressed genes and several pathways regulated by miR-21-5p that may contribute to endometriosis progression. Among them, LUM was found to be significantly diminished expressed in ovarian endometriomas compared to eutopic endometrium. Conclusion In conclusion, this study identified miR-21-5p and LUM as potential factors that may contribute to ovarian endometriomas’ pathogenesis.

Pathogenesis

10.1186/s41936-024-00414-5

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Inactivation of Avian Influenza Viruses by Chemical Disinfectants and the Influence of Faecal Matter

Alexandria Journal of Veterinary Sciences (2023)

Mohamed Samir Mariam Hassan Elbana Alaaeldin Mohamed Saad Amany Abass Gamelat K. Farag

Inactivation of avian influenza viruses (AIVs) using chemical disinfectants is an indispensable biosecurity measure during outbreaks. The efficiency of disinfection process depends on disinfectant type and presence or absence of organic matter. It is also not clear whether AIV pathotype could influence its tolerability to a given disinfectant. Here, we assessed the efficiency of formalin and caustic soda against high (H5N1) and low (H9N2) pathogenic AIVs in the presence and absence of wet faeces. Our results showed that the effectiveness of both disinfectants depends on the target virus with the low pathogenic H9N2 virus being generally more susceptible to disinfection than the high pathogenic H5N1 virus. Wet faeces slightly influenced disinfection action in a virus- and contact time- dependent manner. This study highlights the importance of eliminating faecal matter before initiating a disinfection process and indicates the influence of disinfectant type and AIVs pathotype when selecting the appropriate disinfectant.

Disinfectant

Biosecurity

10.5455/ajvs.134044

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A comparative study of antioxidative, antimicrobial, and anticancer activities of ginger and lemon peel extracts

Delta University Scientific Journal (2024)

Mohamed Samir Ebtehal A. El-Kholany Yasser M. Bakr Essam Shawky A. E. H. Khattab Mohamed I. Ghazy

Owing to their great quantity of various phytochemicals we aimed to investigate the phytochemical composition of ginger and lemon peel aqueous and ethanolic extracts, their potential antimicrobial activity, and anticancer properties. Ginger peel powder possesses the highest phytochemical content compared to lemon peels. The maximum phenolic and flavonoid contents of ginger were extracted in ethanolic extracts, which were documented as 20.65 mg GAE/g and 12.96 mg QC/g compared to lemon peel extracts. Additionally, ethanolic and aqueous ginger peel extracts exhibited superior antioxidant activity (96.91 and 95.77%, respectively) compared to lemon peel extract. HPLC fractionation further revealed the diverse phenolic and flavonoid compounds present in both peels, with ethanolic extracts consistently outperforming their aqueous ones. The ethanolic extracts of both ginger and lemon peels exhibit a higher degree of antimicrobial activity compared to their aqueous extract. Notably, the ethanolic extract of ginger peels demonstrates remarkable inhibition zones, particularly against gram-positive bacteria and gram-negative bacteria. On the other hand, ethanolic extracts of both peels exhibited potent cytotoxic effects against liver and colon carcinoma cells, with ethanolic extract of ginger peel showing superior anticancer potential with IC50 (4.7 and 5.2 µg/ml, respectively). Apoptotic and necrotic cell analyses underscored the ability of ginger peel ethanolic extract to induce a higher level of cancer cell apoptosis while minimizing necrosis. Therefore, our study lies in the distinct phytochemical profile of ginger and lemon peel extracts, emphasizing the higher phenolic and flavonoid contents in ethanolic extracts and their effect as antimicrobial and anticancer activity.

10.21608/dusj.2024.255658.1045

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Behavior and neuropsychiatric changes in experimental chronic toxoplasmosis: Histopathological and immunohistochemical studies

Parasitologists United Journal (2021)

Samia Etewa Mohamed Sarhan Howayda Moawad Samira Mohammad Mohamed Samir

Background: T. gondii is an intracellular protozoan parasite that can establish a latent infection in thecentral nervous system that may develop into chronic inflammation resulting in neurobehavioral problemsin the host. The processes behind these alterations are still largely mysterious.Objective: Detection of behavioral, histopathological and immunohistochemical changes in mice infectedby T. gondii Me49 strain.Material and Methods: A total of 105 adult male Swiss albino mice were divided into 60 used forexperimental infection, and 45 as control. Assessment of physical appearance was monitored foracute toxoplasmosis daily for three weeks post infection (PI). Correlation between behavior changesand the degree of infection was conducted by measuring histopathological (H&E and silver stain) andimmunohistochemical (presence or absence of CD3, CD138 and caspase-3 immunoreactive cells)parameters weekly starting from 7th week to the 12th week PI.Results: Infected mice had neurobehavioral problems. Variable degrees of perivascular and interstitialinflammatory infiltrates, astrocytosis, deteriorated neurons, and meningitis were demonstrated byhistopathology when compared to uninfected controls. Inflammatory cells (mainly lymphocytes) enteredthe parenchyma at mild, moderate, and severe levels in the brains of infected mice. Immunohistochemicalassessment of CD3, CD138 and caspase-3 revealed a substantial increase in CD3 expression by clusters ofactivated astrocytes in the cerebral parenchyma, suggesting an increase in astrocyte numbers and functionthat was progressive over time. CD138 and caspase-3 immunoreactivity showed decreased expression bythe activated astrocytes.Conclusion: Chronic toxoplasmosis causes deterioration in cognitive and emotional behavior of theinfected host, resulting in neuropsychiatric and behavioral disturbances.

Toxoplasmosis

10.21608/puj.2021.75319.1120

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Citations (10)