Abdelmajid Noubhani

Institut Polytechnique de Bordeaux

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Xavier Santarelli

Institut Polytechnique de Bordeaux

Sven J. Saupe

Centre National de la Recherche Scientifique

Antoine Loquet

Institut Européen de Chimie et Biologie

Mélanie Berbon

Institut Polytechnique de Bordeaux

Birgit Habenstein

Centre National de la Recherche Scientifique

Loren B. Andreas

Max Planck Institute for Multidisciplinary Sciences

Nadia El Mammeri

Massachusetts Institute of Technology

Kristaps Jaudzems

Latvijas Organiskās Sintēzes Institūts

Dênis Martinez

Universidade Federal do Rio Grande do Sul

Guido Pintacuda

Centre de RMN à Très Hauts Champs de Lyon

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Centre National de la Recherche Scientifique

105

Université de Bordeaux

Institut Polytechnique de Bordeaux

Institut Européen de Chimie et Biologie

Chimie et Biologie des Membranes et des Nanoobjects

Inserm

Institut de Biochimie et Génétique Cellulaires

Université Claude Bernard Lyon 1

Sorbonne Université

Laboratoire de Biogenèse Membranaire

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Dégradations cellulaires et modifications de l'expression du génome au cours du vieillissement accéléré des semences

Abdelmajid Noubhani

Des semences soumises a un vieillissement accelere (stockage a 42#oc et 100% h. R) presentent une reduction de leur pouvoir germinatif. L'objectif de ce travail etait d'etudier les degradations cellulaires au niveau des biomembranes et des acides nucleiques, cibles privilegiees des formes radicalaires de l'oxygene, au cours du vieillissement accelere des semences. Lorsque la viabilite des semences devient inferieure a 50%, nous observons une reduction de la production d'atp, une augmentation de la fuite des electrolytes vers le milieu d'imbibition, ainsi que l'existence de phenomenes de peroxydation des lipides. Toutefois, la degradation des membranes semble etre un marqueur se manifestant tardivement lors des pertes de viabilite des semences. L'etude des syntheses proteiques montre une correlation entre la perte de la viabilite des semences et l'alteration de leur capacite de synthese in vivo. Des etudes in vitro ont montre une reduction de l'efficacite des systemes de traduction ainsi qu'une baisse de la qualite des arn, alors que la viabilite des semences est encore elevee. Ces resultats montrent que l'alteration des arn et de la synthese des proteines sont des marqueurs precoces rendant compte de la perte de viabilite des semences. Une comparaison des peptides synthetises in vitro ou in vivo nous a permis de mettre en evidence l'existence de modifications de l'expression du genome au cours du vieillissement accelere. L'augmentation des pertes de viabilite des semences en hyperoxie ou en presence d'oxygene singulet, ainsi que l'induction de peptides communs apres stress oxydatifs ou vieillissement accelere, constituent des arguments en faveur de l'intervention de processus oxydatifs au cours du vieillissement des semences

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Cloning, expression and two-step purification of recombinant His-tag enhanced green fluorescent protein over-expressed in Escherichia coli

Journal of Chromatography B (2003)

Wilfrid Dieryck Abdelmajid Noubhani Denis Coulon Xavier Santarelli

Protein purification

Cloning (programming)

Target protein

Downstream processing

FLAG-tag

10.1016/s1570-0232(02)00764-x

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Citations (23)

The selachians’ faunas of the Moroccan phosphate deposits and the KT mass-extinctions

Historical Biology (2010)

Abdelmajid Noubhani

Abstract The Cretaceous and Tertiary phosphate deposits of Morocco which have a vertical thickness covering 25 My (Maastrichtian–Lower Lutetian), are well known for their rich fossil archives. The selachians' fish constitute the most abundant and varied vertebrate faunas. Analysis of the dynamics and patterns of extinctions and faunal renewals identified two significant episodes of high rates of extinction. A mass-extinctions event took place at the end of the Maastrichtian (Cretaceous–Tertiary boundary, KT) when more than 95% of species disappeared. The Lower Ypresian witnessed a second, selective, event which appears to have mainly affected sharks. Geochemical analysis may enlighten the environmental changes. Keywords: selachiansextinctionsfaunal renewalKT boundaryphosphateMorocco Acknowledgements My first thanks go to the OCP 'Direction générale' for administrative authorisations during all my research, and to all the staff of the OCP mining center of Khouribga for their assistance on the field work. Special thanks to David Ward (Tertiary Research group, Kent, UK) and Michael Joseph Duane (Kuwait University, Kuwait) for their kind assistance in reading the manuscript critically, and to the anonymous reviewer(s) for their corrections. I warmly thank Dr Friedrich Pfeil (Mûnchen, Germany) for his permission to use figures and text passages from the monograph published in Palaeo Ichthyologica volume n°8. Notes 1. The Selandian stage remains to be paleontologically characterised both by the study of micro- and macro-faunas, and using tools of geochemistry and paleomagnetism.

Extinction (optical mineralogy)

10.1080/08912961003707349

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Metlaouia Noubhani and Cappetta, 1997 [Chondrichthyes: Orectolobiformes] preoccupied by Metlaouia Dumont, 1928 [Insecta: Lepidoptera]

Acta Palaeontologica Polonica (2002)

Abdelmajid Noubhani Henri Cappetta

Chondrichthyes

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On-line purification of His-tag enhanced green fluorescent protein taken directly from a bioreactor by continuous ultrasonic homogenization coupled with immobilized metal affinity expanded bed adsorption

Journal of Chromatography A (2002)

Abdelmajid Noubhani Wilfrid Dieryck Sylvette Chevalier Xavier Santarelli

Homogenization

Downstream processing

Expanded bed adsorption

Protein purification

10.1016/s0021-9673(02)00794-x

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Citations (19)

Structure–activity relationship of human liver-expressed antimicrobial peptide 2

Peptides (2009)

Agnès Hocquellet Benoı̂t Odaert Charlotte Cabanne Abdelmajid Noubhani Wilfrid Dieryck

Bacillus megaterium

Beta defensin

10.1016/j.peptides.2009.10.006

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Citations (48)

Detection of side-chain proton resonances of fully protonated biosolids in nano-litre volumes by magic angle spinning solid-state NMR

Journal of Biomolecular NMR (2018)

James Tolchard Manoj Kumar Pandey Mélanie Berbon Abdelmajid Noubhani Sven J. Saupe

Magic angle spinning

Side chain

Magic angle

Proton NMR

10.1007/s10858-018-0168-3

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Citations (11)

Effect of accelerated aging on protein synthesis in two legume seeds

HAL (Le Centre pour la Communication Scientifique Directe) (1988)

Xavier Gidrol Abdelmajid Noubhani B. Mocquot Annie Fournier A. Pradet

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Structural and molecular basis of cross-seeding barriers in amyloids

Proceedings of the National Academy of Sciences (2020)

Asen Daskalov Dênis Martinez Virginie Coustou Nadia El Mammeri Mélanie Berbon

Significance Amyloid folds, while performing functional roles in most domains of life, remain a key factor in the emergence and development of multiple neurodegenerative disorders in humans. The significance of our study is twofold: first, by structurally characterizing highly divergent natural prion amyloids, we uncovered that functional amyloids can evolve in a regime of fold conservation, withstanding extreme sequence diversification. Second, we found that virtually identical amyloid backbone structures might not be sufficient for cross-seeding and that key side-chain positions could determine the seeding specificity of an amyloid fold. This work thus sheds light on the fundamental properties of a major category of pathogenic agents.

Amyloid (mycology)

10.1073/pnas.2014085118

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Citations (49)

Reconstitution of ethanolic fermentation in permeabilized spheroplasts of wild‐type and trehalose‐6‐phosphate synthase mutants of the yeast Saccharomyces cerevisiae

European Journal of Biochemistry (2000)

Abdelmajid Noubhani Odile Bunoust Michel Rigoulet Johan M. Thevelein

In the yeast Saccharomyces cerevisiae , TPS1‐ encoded trehalose‐6‐phosphate synthase (TPS) exerts an essential control on the influx of glucose into glycolysis, presumably by restricting hexokinase activity. Deletion of TPS1 results in severe hyperaccumulation of sugar phosphates and near absence of ethanol formation. To investigate whether trehalose 6‐phosphate (Tre6 P ) is the sole mediator of hexokinase inhibition, we have reconstituted ethanolic fermentation from glucose in permeabilized spheroplasts of the wild‐type, tps1Δ and tps2Δ (Tre6 P phosphatase) strains. For the tps1Δ strain, ethanol production was significantly lower and was associated with hyperaccumulation of Glu6 P and Fru6 P . A tps2Δ strain shows reduced accumulation of Glu6 P and Fru6 P both in intact cells and in permeabilized spheroplasts. These results are not consistent with Tre6 P being the sole mediator of hexokinase inhibition. Reconstitution of ethanolic fermentation in permeabilized spheroplasts with glycolytic intermediates indicates additional target site(s) for the Tps1 control. Addition of Tre6 P partially shifts the ethanol production rate and the metabolite pattern in permeabilized tps1Δ spheroplasts to those of the wild‐type strain, but only with glucose as substrate. This is observed at a very high ratio of glucose to Tre6 P . Inhibition of hexokinase activity by Tre6 P is less efficiently counteracted by glucose in permeabilized spheroplasts compared to cell extracts, and this effect is largely abolished by deletion of TPS2 but not TPS1 . In permeabilized spheroplasts, hexokinase activity is significantly lower in a tps2Δ strain compared to a wild‐type strain and this difference is strongly reduced by additional deletion of TPS1 . These results indicate that Tps1‐mediated protein–protein interactions are important for control of glucose influx into yeast glycolysis, that Tre6 P inhibition of hexokinase might not be competitive with respect to glucose in vivo and that also Tps2 appears to play a role in the control of hexokinase activity.

Spheroplast

Hexokinase

Wild type

10.1046/j.1432-1327.2000.01511.x

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Citations (38)