Domingo Garay‐Mendoza

Universidad Autónoma de Nuevo León

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Félix Vílchez‐Cavazos

Universidad Autónoma de Nuevo León

Carlos Acosta‐Olivo

Universidad Autónoma de Nuevo León

Víctor M. Peña‐Martínez

Universidad Autónoma de Nuevo León

Agustín Dávila-Martínez

Universidad Autónoma de Nuevo León

Laura Villarreal‐Martínez

Hospital Universitario Dr José Eleuterio Gonzalez

Yadira Tamez-Mata

Universidad Autónoma de Nuevo León

Mario Simental‐Mendía

Universidad Autónoma de Nuevo León

Marisol Ibarra‐Ramírez

Universidad Autónoma de Nuevo León

Santiago de la Garza-Castro

Universidad Autónoma de Nuevo León

L. Villarreal

Universidad Autónoma de Nuevo León

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Universidad Autónoma de Nuevo León

Hospital Universitario Dr José Eleuterio Gonzalez

Hispanics in Philanthropy

University of Monterrey

Medicina

Tecnológico de Monterrey

Weatherford College

Sociedad Española de Cirugía Ortopédica y Traumatología

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Instituto Nacional de Neurología y Neurocirugía

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The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

International Journal of Rheumatic Diseases (2017)

Domingo Garay‐Mendoza Laura Villarreal‐Martínez Alejandra Garza‐Bedolla Daniela Michelle Pérez‐Garza Carlos Acosta‐Olivo

Abstract Aim Management of osteoarthritis ( OA ) is basically symptomatic. Recently, stem cells ( SC ) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra‐articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA . Method This was a prospective, open‐label, phase I/ II clinical trial to assess the safety and efficacy of a single intra‐articular injection of autologous stimulated bone marrow stem cells ( BM ‐ SC ) in patients with knee OA . Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G‐ CSF ). SC were obtained by BM aspiration and administered in a single intra‐articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT 01485198. Results A total of 61 patients were included. Socio‐demographic characteristics, OA grades and initial scores were similar in both groups. The BM ‐ SC group showed significant improvement in knee pain and quality of life during the 6‐month follow‐up. Conclusion The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA .

Knee pain

10.1111/1756-185x.13139

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How Does Comprehensive Care Impact Life of Pediatric Patients With Hemophilia? Results From a Center in a Developing Country

Journal of Pediatric Hematology/Oncology (2019)

Laura Villarreal‐Martínez Atenas Meléndez-Aguirre Marcela Cantú-Moreno Domingo Garay‐Mendoza José A. Garza

Background: Quality of life (QoL) has been included as a marker of treatment effectiveness in pediatric patients with chronic diseases. We believe that frequent multidisciplinary interventions and patient education could lead to an improvement in QoL. Aims: Determine the QoL and economic impact of monthly interventions in multidisciplinary treatment. Materials and Methods: The Haemo-QoL questionnaire was applied to patients who attended the hemophilia center of the University Hospital “Dr. José Eleuterio González,” Monterrey, Mexico, at the time of enrollment and 1 year later. Results: Male patients between 4 and 16 years diagnosed with hemophilia were included. The score results presented are based on Haemo-QoL versions that classify patients by their age group: group 1 (4 to 7 y) and group 2 (8 to 12 y). Statistical significant improvement was observed in the overall score (sociodemographic, psychosocial, etc.) after 1 year of follow-up in both groups ( P <0.05). Conclusions: Impact on the QoL of patients receiving this approach was favorable. Improvement was observed regardless of severity and in those who were already in prophylaxis, suggesting that this type of approach could be causing the improvement. Results support the application of multidisciplinary treatment as the gold standard, and it should be considered in all centers including those with limited resources.

10.1097/mph.0000000000001575

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First Comparative Study of the Effectiveness of the Use of Tranexamic Acid against ε-Aminocapróic Acid via the Oral Route for the Reduction of Postoperative Bleeding in TKA: A Clinical Trial

The Journal of Knee Surgery (2019)

Rodolfo Morales-Ávalos Tomás Ramos-Morales Ana María Espinoza-Galindo Domingo Garay‐Mendoza Víctor M. Peña‐Martínez

Total primary knee replacement results in significant postoperative bleeding. There are reports that 20 to 50% of the patients require a blood transfusion, which has been related to many complications, resulting in the search for strategies to reduce bleeding. The use of oral antifibrinolytics is becoming a low cost and safe way of achieving this goal. The hypothesis of this study was that the use of oral aminocaproic acid could provide similar results to the use of oral tranexamic acid (TXA). The purpose was to compare the effects of oral aminocaproic acid as a hemostatic agent versus the use of oral TXA administered in multiple doses pre and postsurgery in patients undergoing total primary knee replacement. We enrolled 92 patients that were randomly divided into two groups: received three doses of aminocaproic acid (2,000 mg per dose) or three doses of oral TXA (1,300 mg per dose). The drugs were administered according to the following schedule: 2 hours before surgery and 6 and 12 hours after surgery. The variables that were analyzed to compare the effectiveness of the hemostatic agents were total blood loss; hidden blood loss; external blood loss; transfusion rate; intraoperative blood loss; decreases in hemoglobin and hematocrit values; surgical drainage output; visual analogue scale; and surgical complications. There were no significant differences between any of the study variables for the group receiving oral aminocaproic acid and the group receiving oral TXA (p > 0.05), with the exception of patients who received TXA, who presented with more adverse events (p = 0.04). Our study showed that the use of oral aminocaproic acid was similar to its counterpart TXA regarding the evaluated parameters. Although patients who received TXA presented an average of 140 mL less blood loss than patients in the ε-ACA group, the difference did not appear to be clinically important, the transfusion rate was very low, and there were no between-group differences in postoperative complications.

10.1055/s-0039-1696722

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Primary hypertrophic osteoarthropathy: Report of two novel genetic variants in the SLCO2A1 gene in two Mexican patients

Indian Journal of Dermatology Venereology and Leprology (2018)

Alejandra Villarreal‐Martínez O.T. Vázquez‐Martínez L. Villarreal Domingo Garay‐Mendoza C. Rodriguez-Vivian

Spinal osteoarthropathy

Hypertrophic Osteoarthropathy

Primary (astronomy)

10.4103/ijdvl.ijdvl_414_17

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Lesiones de ligamento cruzado anterior tratadas con autoinjerto de tendón de cuádriceps versus autoinjerto de isquiotibiales: estudio controlado aleatorizado

Cirugía y Cirujanos (2020)

Félix Vílchez‐Cavazos Agustín Dávila-Martínez Santiago de la Garza-Castro Mario Simental‐Mendía Domingo Garay‐Mendoza

Background: One of the most common grafts used to repair anterior cruciate ligament (ACL) rupture is the hamstring tendon (HT) autograft.However, another proposed option to repair the ACL is the quadriceps tendon (QT) autograft.This study aimed to compare the pain and clinical results between patients with ACL injury treated with QT autograft and with HT autograft.Materials and methods: The Ethics and Investigation Committee of our institution approved the study.The patients were randomized into two groups: one group was treated with QT autograft and the other group was treated with HT autograft.The patients were evaluated preoperatively and postoperatively using the Lysholm-Tegner score, International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, and visual analog scale (VAS), at 2 weeks and 1, 3, 6, and 12 months.Results: A total of 28 patients with a primary ACL injury were included in the study.No significant differences in VAS pain, Lysholm knee and Tegner activity scale scores, and IKDC score between the HT and QT groups were observed at any time point.All patients had favorable outcomes and significantly improved evaluation scores.Conclusion: The patients treated with QT autograft had clinical results and post-operative pain similar to those of patients treated with HT autograft for ACL reconstruction.

10.24875/ciru.19001001

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Citations (14)

Anterior cruciate ligament injuries treated with quadriceps tendon autograft versus hamstring autograft: A randomized controlled trial

Cirugía y Cirujanos (English Edition) (2022)

Félix Vílchez‐Cavazos Agustín Dávila-Martínez Santiago de la Garza-Castro Mario Simental‐Mendía Domingo Garay‐Mendoza

10.24875/cirue.m20000110

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Citations (7)