Yanan Lei

Shaanxi Normal University

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i-10 index

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Yuhuan Zhang

Shaanxi Normal University

Yan Gao

Jilin University

Haomeng Wang

CanSino (China)

Qingwei Yao

Jiangnan University

Qinglei Liu

Shanghai Institute of Technology

Dongdong Xie

Anhui Medical University

Wei Wang

Shanghai Jiao Tong University

Hao Lü

Chinese Academy of Sciences

Zhong Zhang

Shanghai First People's Hospital

Peng Yu

Tianjin University of Science and Technology

Cooperative Institutions

Denali Therapeutics (United States)

Shaanxi Normal University

Chinese Academy of Sciences

First Affiliated Hospital of Dalian Medical University

Tianjin University of Science and Technology

Dalian Medical University

Sichuan University

China International Science and Technology Cooperation

University of Chinese Academy of Sciences

Central South University

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Author response for "Effect of sucrose levels on dynamic rheology properties of dough during fermentation process"

Dongdong Xie Yanan Lei Xing Li

10.1111/ijfs.16291/v2/response1

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Intestinal flora and ulcerative colitis: A Mendelian Randomization study

Research Square (Research Square) (2024)

Fanfan Qu Ming Cheng Hongxia Wang Jianbin Ji Yanan Lei

Abstract A large body of clinical data and observational studies suggest that intestinal flora is associated with ulcerative colitis (UC). However, the causal relationship between gut flora and UC remains to be determined. To investigate the potential causal relationship between intestinal flora and UC, a two-sample Mendelian randomization (MR) analysis was performed in this study. We obtained genome-wide association data for gut flora and UC from published GWAS databases and performed dual sample MR analysis using inverse variance weighting (IVW) to identify potential UC beneficial or deleterious gut flora. Sensitivity analysis, including multi potency and heterogeneity assays, was performed to validate the stability of MR primary assays. In this study, we found a negative correlation between three genera of bacteria and the risk of UC developing into beneficial floras. They include Genus Butyrivibrio [OR = 0.908, 95%CI (0.835, 0.987), P = 0.0229]; Genus Clostridiuminnocuumgroup [OR = 0.847, 95%CI (0.752, 0.955), P = 0.00646]; and Genus Lactococcus [OR = 0.886, 95%CI (0.796, 0.986), P = 0.0263]. The analysis of pleiotropy showed that the MR-Egger regression intercept P > 0.05 for all three, and the Q-pval > 0.05 for the heterogeneity analysis, indicating that there was no pleiotropy or heterogeneity in the above-mentioned bacterial groups. This study expands the intestinal flora associated with UC risk and provides a theoretical basis for further relevant experiments and clinical studies.

Mendelian Randomization

Flora

Pleiotropy

10.21203/rs.3.rs-4005538/v1

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Energy Security Strategies of Countries along the “Belt and Road” in the Post COVID-19 Era

Advances in Economics and Management Research (2022)

Shigang Yan Peng Yu Yanan Lei

The energy security issues of countries along the “Belt and Road” become increasingly important due to the strategic nature of energy resources and prominent ecological damage. The paper analyzed the new development of energy security in the post COVID-19 era, and stated the new challenges in terms of the geopolitical risks, increasing energy market volatility, and energy security governance for the countries along the “Belt and Road”. Finally, the paper put forward countermeasures and suggestions to improve the energy security level of the countries along the “Belt and Road”.

Energy Security

Geopolitics

10.56028/aemr.1.1.41

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A Colorimetric Chemosensor Based on Fluorescein for the Detection of Zn2+ in Aqueous Solution

Heterocycles (2016)

Yan Gao Wei Wang Yanan Lei

A novel quinoline-functionalized fluorescein derivative HL was designed and used as a colorimetric chemosensor for the detection of Zn 2+ over other commonly coexistent metal ions in aqueous solution at pH 7.2.Studies on its binding with different metal ions revealed a noticeable naked eye color change in the presence of Zn 2+ .The mechanism has been supported by Job's plot evaluation, MS and 1 H NMR spectroscopic studies.The association constant and the detection limits of sensor HL to Zn 2+ were determined as 1.17×10 5 M -1 and 5.7 nM.This excellent selectivity and sensitive of HL to Zn 2+ exhibited its potential application value in the biological monitoring and tracking of Zn 2+ .

Naked eye

Quinoline

Binding constant

Derivative (finance)

10.3987/com-16-13475

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Citations (3)

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis

Journal of Medicinal Chemistry (2022)

Robert A. Craig Brian M. Fox Cheng Hu Katrina W. Lexa Maksim Osipov

Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative diseases. Herein, we use ligand- and structure-based drug design approaches for identifying novel amino-pyrazine inhibitors of DLK/LZK. DN-1289 (14), a potent and selective dual DLK/LZK inhibitor, demonstrated excellent in vivo plasma half-life across species and is anticipated to freely penetrate the central nervous system with no brain impairment based on in vivo rodent pharmacokinetic studies and human in vitro transporter data. Proximal target engagement and disease relevant pathway biomarkers were also favorably regulated in an in vivo model of amyotrophic lateral sclerosis.

Leucine-rich repeat

10.1021/acs.jmedchem.2c01056

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Citations (13)

Selective Zn²⁺ Recognition of Novel Triazole Schiff-Base Derivatives Bearing the Coumarin Group

Journal of Chemical Research (2014)

Wei Wang Shuai Qi Qinglei Liu Yanan Lei Wen-Jing Yuan

Three novel triazole Schiff-bases derivatives bearing coumarin units have been synthesised from 3,5-diaryl-4-amino-1,2,4-triazole with three kinds of coumarin aldehydes. The UV-Vis absorption and fluorescence emission spectra of ( E)-4-((3,5-diphenyl-4H-1,2,4-triazol-4-ylimino)methyl)-7-methoxy-2H-chromen-2-one exhibited blue-shifted absorption and fluorescent enhancement upon chelation to zinc ion as a 2: 1 ligand-to-metal complex with a binding constant of 3.29 × 10 6 M −1 .

Triazole

Binding constant

1,2,4-Triazole

10.3184/174751914x14115551312011

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Citations (3)

Extraction, functionality, and applications of Chlorella pyrenoidosa protein/peptide

Current Research in Food Science (2023)

Qiming Wu Yuchen Ma Lanxin Zhang Jing Han Yanan Lei

Chlorella pyrenoidosa (C. pyrenoidosa) has been widely used in commercial food and feed production for numerous years. Its high protein content and cost-effectiveness make it an attractive source of novel protein. With a focus on sustainable development and the search for green natural products, current research is dedicated to maximizing the utilization of C. pyrenoidosa protein (CPP) and peptide. Various techniques, such as the use of ionic liquids, freeze-thawing, ultrasonication, enzyme digest, microwaving are employed in the extraction of CPP. The extracted CPP has demonstrated antioxidant, anti-inflammatory, and bacteriostatic properties. It can also stimulate immune regulation, prevent cardiovascular disease, protect red blood cells, and even be used in wastewater treatment. Furthermore, CPP has shown some potential in combating obesity. Additionally, CPP is being explored in three-dimensional (3D) printing applications, particularly for the creation of biological scaffolds. It is also anticipated to play a role in 3D food printing. This review aimed to supply a comprehensive summary of CPP and C. pyrenoidosa peptide extraction methods, their functions, and practical applications in various industries. By doing so, it seeks to underpin subsequent research efforts, highlight current research limitations, and identify future research directions in this field.

Chlorella pyrenoidosa

Sonication

10.1016/j.crfs.2023.100621

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Citations (12)

Synthesis, α-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones

Bioorganic & Medicinal Chemistry Letters (2015)

Hua Sun Yashan Li Xiaoting Zhang Yanan Lei Weina Ding

Flavones

Docking (animal)

10.1016/j.bmcl.2015.08.059

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Citations (54)

Biochar-supported Cu nanocluster as an electrochemical ultrasensitive interface for ractopamine sensing

Food Chemistry X (2022)

Yanan Lei Yuhuan Zhang Yuan Li Jianke Li

Electrochemical sensors actually involve an electrocatalytic process involving an efficient and selective energy conversion that is related to the morphology and size of the interface of the modified materials. Ultrasmall nanoclusters or single atoms generate a greater catalytic ability than normal nanomaterials. In this study biochar-supported Cu nanoclusters (CuNCs@CNFs) were fabricated via a carbon confinement synthesis method toward ultrasensitive electrochemical sensing of ractopamine (RAC). RAC is a β-adrenergic receptor agonist that is illegally used as a feed additive to significantly improve muscle accretion, resulting in RAC accumulation in meat-based food products. The unique structure of CuNCs@CNFs and the interconnectivity between the CuNCs and the CNFs enable the nanocomposite to significantly enhance conductivity and electrocatalytic activity. Using the CuNCs@CNFs-based sensor, RAC was determined with a high sensitivity of 1641 μA μM-1 cm-2. The feasibility of detecting RAC in spiked meat samples was also carried out with satisfactory recoveries ranging from 91.39 % to 94.58 %.

Ractopamine

Nanoclusters

Interconnectivity

Nanomaterials

Electrochemical gas sensor

10.1016/j.fochx.2022.100404

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Citations (9)

Degraded polysaccharide from Lycium barbarum L. leaves improve wheat dough structure and rheology

LWT (2021)

Majida Al‐Wraikat Chen Hou Guangtao Zhao Hao Lü Hengkai Zhang

Lycium

10.1016/j.lwt.2021.111372

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Citations (37)