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Chihiro Yokoyama

Hiroshima University

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Hirotaka Onoe

Kobe Gakuin University

Yasuhiko Ibata

Kyoto Prefectural University of Medicine

Kenji Fukui

Osaka University

Yasuyoshi Watanabe

RIKEN Center for Biosystems Dynamics Research

Yasuhito Nakatomi

Osaka City University

Hitoshi Okamura

Hiroshima University

Kayo Onoe

RIKEN Center for Biosystems Dynamics Research

Akihiro Kawasaki

Ritsumeikan University

Takuya Hayashi

RIKEN Center for Biosystems Dynamics Research

Hisashi Doi

RIKEN Center for Biosystems Dynamics Research

Cooperative Institutions

Kyoto University

The University of Tokyo

Kyoto Prefectural University of Medicine

Osaka University

RIKEN Center for Biosystems Dynamics Research

Centre National de la Recherche Scientifique

RIKEN Center for Computational Science

Japan Science and Technology Agency

RIKEN

Osaka City University

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Molecular Brain Imaging of Personality Traits in Nonhuman Primates: A Study of the Common Marmoset

Primatology monographs (2011)

Chihiro Yokoyama Hirotaka Onoe

In vivo noninvasive brain imaging with positron emission tomography (PET) using positron-labeled tracers that bind to target molecules enables quantitative brain mapping of molecules across species, including humans. We established a PET imaging method for conscious common marmosets (Callithrix jacchus), a small primate species noted for its high social tolerance and cooperative sociality. We used this method to examine the dopaminergic and serotonergic systems of the common marmoset brain. In particular, we examined the relation between factorial scores of behavioral personality traits and binding potentials of serotonin and dopamine transporters, which regulate rates of neurotransmission, using radioligands such as [11C]DASB and [11C]PE2I, respectively. We found specific neurochemical and neuroanatomical associations with personality traits of individual common marmosets that mirror those in humans. These results demonstrate that molecular brain imaging combined with quantitative behavioral analysis can provide valuable information for understanding the neural bases of personality in nonhuman primates and, potentially, humans. Studies of this type can also be useful in highlighting how genes and the environment influence personality.

Neurochemical

10.1007/978-4-431-53892-9_19

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Citations (5)

Self-mutilation behavior and brain dopamine in neonatal 6-hydroxydopamine treated rats. 21 an autoradiographic analysis of dopamine D2 receptr using [3H]YM 09151-2

Neuroscience Research Supplements (1992)

Chihiro Yokoyama Hitoshi Okamura Yasuhiko Ibata

Hydroxydopamine

10.1016/0921-8696(92)90820-q

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Citations (1)

GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice

Communications Biology (2024)

Rahmawati Aisyah Noriyasu Ohshima Daiki Watanabe Yoshiko Nakagawa Tetsushi Sakuma

Glycerophosphocholine (GPC) is an important precursor for intracellular choline supply in phosphatidylcholine (PC) metabolism. GDE5/Gpcpd1 hydrolyzes GPC into choline and glycerol 3-phosphate; this study aimed to elucidate its physiological function in vivo. Heterozygous whole-body GDE5-deficient mice reveal a significant GPC accumulation across tissues, while homozygous whole-body knockout results in embryonic lethality. Skeletal muscle-specific GDE5 deletion (Gde5 skKO) exhibits reduced passive force and improved fatigue resistance in electrically stimulated gastrocnemius muscles in vivo. GDE5 deficiency also results in higher glycolytic metabolites and glycogen levels, and glycerophospholipids alteration, including reduced levels of phospholipids that bind polyunsaturated fatty acids (PUFAs), such as DHA. Interestingly, this PC fatty acid compositional change is similar to that observed in skeletal muscles of denervated and Duchenne muscular dystrophy mouse models. These are accompanied by decrease of GDE5 expression, suggesting a regulatory role of GDE5 activity for glycerophospholipid profiles. Furthermore, a DHA-rich diet enhances contractile force and lowers fatigue resistance, suggesting a functional relationship between PC fatty acid composition and muscle function. Finally, skinned fiber experiments show that GDE5 loss increases the probability of the ryanodine receptor opening and lowers the maximum Ca

10.1038/s42003-024-06298-z

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Citations (4)

Common marmoset (Callithrix jacchus) personality, subjective well-being, hair cortisol level and AVPR1a, OPRM1, and DAT genotypes

Scientific Reports (2018)

Miho Inoue‐Murayama Chihiro Yokoyama Yumi Yamanashi Alexander Weiß

Abstract We studied personality, subjective well-being, and hair cortisol level, in common marmosets Callithrix jacchus , a small, cooperatively breeding New World monkey, by examining their associations with one another and genotypes. Subjects were 68 males and 9 females that lived in the RIKEN Center for Life Science Technologies. Personality and subjective well-being were assessed by keeper ratings on two questionnaires, hair samples were obtained to assay cortisol level and buccal swabs were used to assess AVPR1a , OPRM1 and DAT genotypes. Three personality domains—Dominance, Sociability, and Neuroticism—were identified. Consistent with findings in other species, Sociability and Neuroticism were related to higher and lower subjective well-being, respectively. Sociability was also associated with higher hair cortisol levels. The personality domains and hair cortisol levels were heritable and associated with genotypes: the short form of AVPR1a was associated with lower Neuroticism and the AA genotype of the A111T SNP of OPRM1 was related to lower Dominance, lower Neuroticism, and higher hair cortisol level. Some genetic associations were not in directions that one would expect given findings in other species. These findings provide insights into the proximate and ultimate bases of personality in common marmosets, other primates and humans.

Buccal swab

Dominance (genetics)

10.1038/s41598-018-28112-7

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Citations (49)

Relationship between the destruction of dopaminergic neurons and self-mutilation behavior in the neonatally 6-hydroxydopamine treated rats

Neuroscience Research Supplements (1991)

Hitoshi Okamura Chihiro Yokoyama Fumio Kawakami Yasuhiko Ibata

Hydroxydopamine

10.1016/s0921-8696(06)80363-4

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Citations (1)

Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids

Neuroreport (2011)

Kayo Takahashi Kayo Onoe Hisashi Doi Hiroko Nagata Gen Yamagishi

In an earlier study in rodents, we showed that the aromatase that converts androgens to estrogens in the preoptic area and bed nucleus of stria terminalis was significantly increased in concentration after exposure to anabolic-androgenic steroids. To confirm whether this occurs in primates, we conducted a positron emission tomographic study using macaque monkeys. Male rhesus monkeys were treated with nandrolone decanoate for 3 weeks. To measure aromatase concentrations, we performed positron emission tomographic imaging using a 11C-labeled specific aromatase inhibitor, [11C]vorozole. After treatment with nandrolone, significant increase in [11C]vorozole binding was observed in the hypothalamus but not other areas including the amygdala, which is also aromatase enriched. These findings in monkeys are consistent with those we obtained earlier in rats. These findings strongly suggest that aromatase in the hypothalamus may play a crucial role in the emotional instability of anabolic-androgenic steroids abusers.

Nandrolone

Aromatase inhibitor

10.1097/wnr.0b013e3283460282

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Citations (11)

Evaluation of dopamine D2/D3 and serotonin 5-HT2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography

Psychopharmacology (2012)

Shunsuke Nakazawa Chihiro Yokoyama Naohiro Nishimura Tomoko Horisawa Akihiro Kawasaki

Lurasidone

Raclopride

Extrapyramidal symptoms

10.1007/s00213-012-2815-9

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Citations (14)

1P248 Poisson and fractal processes in the locomotor activity in ant and mouse

Seibutsu Butsuri (2005)

Kazumitsu Hanai Yuji Satoji R. Yamaoka Mamiko Ozaki Chihiro Yokoyama

Locomotor activity

10.2142/biophys.45.s93_4

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Serotonergic mediation of the antidepressant-like effect of the green leaves odor in mice

Neuroscience Letters (2008)

Yasuhito Nakatomi Chihiro Yokoyama Seijiro Kinoshita Daiki Masaki Hideto Tsuchida

Citalopram

Desipramine

Serotonin reuptake inhibitor

Hypoactivity

Reuptake

10.1016/j.neulet.2008.03.013

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Citations (34)

Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown

Scientific Reports (2016)

Masafumi Takaji Atsushi Takemoto Chihiro Yokoyama Akiya Watakabe Hiroaki Mizukami

Abstract The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation exists between the caudate nucleus and putamen in primates. Here, we successfully decreased dopamine D1 receptor (D1R) or D2R mRNA expression levels selectively in the marmoset caudate using shRNA knockdown techniques, as determined using positron emission tomography imaging with specific D1R and D2R ligands and postmortem in situ hybridization analysis. We then conducted a voxel-based correlation analysis between binding potential values of PET imaging and visual discrimination learning task performance in these genetically modified marmosets to find a critical role for the caudate D2R but no apparent role for the caudate D1R. This latter finding challenges the current understanding of the mechanisms underlying D1R activation in the caudate.

Caudate nucleus

10.1038/srep35809

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Citations (27)

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