Altamira Arce-Cerezo

Hospital Clínic de Barcelona

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Jordi Ribera

Hospital Clínic de Barcelona

Denise Oró

Gubra (Denmark)

Eudald Casals

Wuyi University

Manuel Morales‐Ruiz

Universitat de Barcelona

Bernat Córdoba‐Jover

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Guillermo Fernández–Varo

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

M. Pauta

Hospital Clínic de Barcelona

Víctor Puntes

Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

Gregori Casals

Universitat de Barcelona

Wladimiro Jiménez

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

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Hospital Clínic de Barcelona

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Universitat de Barcelona

Fundació Clínic per a la Recerca Biomèdica

Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer

Instituto de Salud Carlos III

Vall d'Hebron Institut de Recerca

Institut Català de Nanociència i Nanotecnologia

Institució Catalana de Recerca i Estudis Avançats

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Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats

Journal of Nanobiotechnology (2019)

Bernat Córdoba‐Jover Altamira Arce-Cerezo Jordi Ribera M. Pauta Denise Oró

Cerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of these nanoparticles on hepatic regeneration after liver injury by partial hepatectomy and acetaminophen overdose.All the in vitro experiments were performed in HepG2 cells. For the acetaminophen and partial hepatectomy experimental models, male Wistar rats were divided into three groups: (1) nanoparticles group, which received 0.1 mg/kg cerium nanoparticles i.v. twice a week for 2 weeks before 1 g/kg acetaminophen treatment, (2) N-acetyl-cysteine group, which received 300 mg/kg of N-acetyl-cysteine i.p. 1 h after APAP treatment and (3) partial hepatectomy group, which received the same nanoparticles treatment before partial hepatectomy. Each group was matched with vehicle-controlled rats.In the partial hepatectomy model, rats treated with cerium oxide nanoparticles showed a significant increase in liver regeneration, compared with control rats. In the acetaminophen experimental model, nanoparticles and N-acetyl-cysteine treatments decreased early liver damage in hepatic tissue. However, only the effect of cerium oxide nanoparticles was associated with a significant increment in hepatocellular proliferation. This treatment also reduced stress markers and increased cell cycle progression in hepatocytes and the activation of the transcription factor NF-κB in vitro and in vivo.Our results demonstrate that the nanomaterial cerium oxide, besides their known antioxidant capacities, can enhance hepatocellular proliferation in experimental models of liver regeneration and drug-induced hepatotoxicity.

Acetaminophen

Liver Regeneration

Cerium oxide

10.1186/s12951-019-0544-5

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