A Gabryelewicz

Medical University of Białystok

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J Stasiewicz

Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego

W Szałaj

Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego

J Długosz

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego

J Prokopowicz

Medical University of Białystok

I Kinalska

Medical University of Białystok

Grażyna Rydzewska

Jan Kochanowski University

WŁ

W Łaszewicz

University Clinical Hospital In Bialystok

A Dâbrowski

Medical University of Białystok

Janusz Prokopczuk

University of Belgrade

N Wołosowicz

Medical University of Białystok

Cooperative Institutions

Medical University of Białystok

Jagiellonian University

University Clinical Hospital In Bialystok

Medical University of Warsaw

University School of Physical Education in Kraków

New York Academy of Medicine

Maj Institute of Pharmacology

Polish Academy of Sciences

University Hospital, Newark

University of Münster

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Lysosomal-mitochondrial interrelationships in damage to the liver in acute experimental pancreatitis in dogs. Treatment with prostacyclin (PGI2)

International Journal of Pancreatology (1988)

Jan Długosz E Pawlicka A Gabryelewicz

In acute pancreatitis, damage to the liver is an important aspect of multiorgan failure. In 28 dogs (20 with bile-trypsin induced acute experimental pancreatitis (AEP)), ‘total’ and ‘free’ activity of lysosomal hydrolases: β-glucuronidase, cathepsins and acid phosphatase in mitochondrial and lysosomal subfraction of the liver were determined 12 h or 24 h after the induction of AEP. The respiratory control ratio with sodium succinate as a substrate, using Clarck's electrode and uncoupler-dependent ATP-ase activity in mitochondrial subfraction, was assayed. Groups of dogs were treated or pretreated with prostacyclin (PGI2), 20 ng·kg−1·min−1 1.v. for 12 or 13 h. The relative free activity of hydrolases was significantly elevated in untreated AEP after 12 h and was partially normalized in AEP after 24 h or after 12 h followed by treatment and pretreatment with PGI2. Respiratory control ratio was twice lower than normal in AEP after 12 h and partially normalized after 24 h post PGI2 treatment. The relative free activity of lysosomal hydrolases was highly negatively correlated with respiratory control ratio. It was concluded, that during AEP in dogs the function of liver mitochondria and lysosomal stability are impaired. The significant correlation found between the mitochondrial and lysosomal lesions points to lysosomal-mitochondrial interactions in liver damage in AEP. Prostacyclin in the investigated dose partially prevents the mitochondrial and lysosomal lesions in liver in this disease.

10.1007/bf02788468

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Citations (7)

The effect of nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) on multiorgan oxidant-antioxidant balance in acute experimental pancreatitis.

PubMed (1994)

A Dâbrowski A Gabryelewicz

This study was undertaken to determine whether synthetic proteinase inhibitors--nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) have any influence on multiorgan oxidant-antioxidant balance in acute haemorrhagic pancreatitis induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate. Rats were treated with FUT-175 25 x 10(-3) g.kg-1.h-1) or FOY (2.5 x 10(-3) g.kg-1.h-1) and sacrificed at 3 h. Malondialdehyde and sulfhydryl groups concentration, as an index of oxidative stress, we measured in pancreatic, lung and liver tissue. In rats with acute pancreatitis treated with these proteinase inhibitors, oxidative stress expressed by malondialdehyde elevation and sulfhydryl groups depletion, was markedly diminished. It was observed in the pancreas and lung, and to a lesser extent in the liver. These effects of FUT-175 or FOY treatment, at least in part, may account for recently postulated favorable systemic effects of such a medication.

Malondialdehyde

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An evaluation of arbaprostil at multiple doses for the treatment of acute duodenal ulcer: a randomized double-blind placebo-controlled international trial.

PubMed (1990)

A R Euler J Krawiec H Odes Tuvia Gilat Luis Garcı́a

Six hundred and thirty patients were enrolled in a randomized double-blind placebo-controlled trial evaluating two arbaprostil dosages (25 micrograms and 50 micrograms) qid for 4 wk for the treatment of acute duodenal ulcers. The healing rates in the placebo, 25-micrograms, and 50-micrograms treatment groups were 39%, 51%, and 60%, respectively. Smoking was found to adversely affect the healing rates in all the treatment groups. Pain severity was less with either arbaprostil treatment. The only side effect found was diarrhea: 10%, 14%, and 32% in the placebo, 25-micrograms, and 50-micrograms treatment groups, respectively. Severe diarrhea occurred in 1% of those patients who received the 50-micrograms dosage regimen, but in none of the other two groups. Arbaprostil at these two dosage levels, when given for 4 wk, appears to be a safe and efficacious agent for the treatment of acute duodenal ulcers.

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Placebo-controlled study

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Citations (2)

[Case of gastric polyposis].

PubMed (1972)

J Stasiewicz A Gabryelewicz Janusz Prokopczuk J Popow Stasikiewicz-Chmielewska

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Effect of dimethylsulfoxide-hydroxyl radical scavenger on cerulein-induced acute pancreatitis in rats.

PubMed (1991)

A Dâbrowski A Gabryelewicz M Dąbrowska L Chyczewski

Acute oedematous pancreatitis was induced in Wistar male rats by intravenous (i.v.) infusion of cerulein at the rate of 5.10(-6)g.kg-1.h-1 for 3 or 6 hrs. The effects of dimethylsulfoxide (DMSO)-hydroxyl radical scavenger in this model of disease were examined. DMSO was injected i.v., 0.75 g.kg-1, at 0 and 3 hrs during cerulein infusion. Treatment with this agent exerted a protective effect on the rat pancreas in the cerulein-induced acute pancreatitis. This effect is expressed by inhibition of lipid peroxidation in pancreatic tissue, less oedema formation, diminution of hyperlipasemia and a significant reduction in acinar cell vacuolisation. Our data suggest that besides the hydroxyl radical, other oxidants (secondary?) may cause cytotoxicity in this model of disease. We suggest that phagocytic inflammatory cells provide such oxidants.

Hydroxyl radical

Scavenger

Acinar cell

Free radical scavenger

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Citations (4)

Oxidative stress

International Journal of Pancreatology (1992)

A Dâbrowski A Gabryelewicz

Acute hemorrhagic pancreatitis was induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate. Rats were sacrificed at 1, 3, 6, and 24 h. Malondialdehyde and sulfhydryl groups concentration, as well as superoxide dismutase and catalase activity were measured in pancreatic, liver, and lung tissue. These parameters, with the exception of catalase, were also determined in serum and peritoneal exudate. Early and profound oxidative stress in each organ was evidenced by marked increases in malondialdehyde concentrations along with marked reductions in levels of sulfhydryl groups and superoxide dismutase; a paradoxical increase in catalase activity, perhaps compensatory, was noted in pancreas and lung. Survival for 24 h was associated with restoration of normality insofar as tissue malondialdehyde concentrations were concerned, but pancreas sulfhydryl groups remained markedly depleted. These data endorse the suggestion that the early provision of such compounds may help to accelerate recovery from hemorrhagic pancreatitis in humans.

Malondialdehyde

10.1007/bf02924357

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Citations (41)

Ranitidine effect on gastric mucosa damage in patients with rheumatoid diseases on long-term treatment with non-steroid anti-inflammatory drugs.

PubMed (1986)

J. Piotrowski A Gabryelewicz S Konturek N Kwiecień Grażyna Rydzewska

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Citations (2)

The effect of tilsuprost on the liver mitochondria in taurocholate pancreatitis in rats with antecedent acute ethanol abuse

Life Sciences (1996)

Jan Długosz Cezary Popławski E Pawlicka Eugeniusz Wróblewski A Gabryelewicz

10.1016/0024-3205(96)00455-9

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Citations (1)

The Role of OMGE In Education and Training: Working Group 5

Scandinavian Journal of Gastroenterology (1989)

F Vilardell C. Tasman Jones Karen Henley Basanta Tandon A Gabryelewicz

OMGE is a federation of national gastroenterology societies which may enjoy a different overall status in each different country. No role for OMGE in the graduate teaching of gastroenterology is envisaged. OMGE should confine itself to postgraduate teaching and education, since graduate education may vary considerably in different countries in accordance with epidemiology, local needs, and primary and secondary care organization. The OMGE education survey conducted by Myren et al. (1) clearly shows that there are wide differences in the size and the estimated needs of the speciality, the formal requirements for specialization, and, obviously, the training and educational programs implemented in each nation. The ultimate goal of OMGE, which is to provide guidelines and minimal recommendations for an optimal organization of education and training, is still distant; however, the following recommendations derived from the OMGE educational survey may be pertinent to the future role of OMGE.

10.3109/00365528909091054

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Study of the inhibitory effect of lyophilized pancreatic juice on iron absorption in rat intestine.

PubMed (1974)

A Gabryelewicz Janusz Prokopczuk J Stasiewicz Maciej Szmitkowski

Pancreatic juice

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