Carol Y. Cheung

Chinese University of Hong Kong

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i-10 index

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Co-Authors

Tien Yin Wong

National University of Singapore

289

Tin Aung

Singapore Eye Research Institute

M. Kamran Ikram

Erasmus MC

Ching‐Yu Cheng

National University of Singapore

Ecosse L. Lamoureux

Duke-NUS Medical School

Christopher Chen

National University of Singapore

Christopher Kai-Shun Leung

Chinese University of Hong Kong

Seang‐Mei Saw

National University of Singapore

Clement C. Tham

Chinese University of Hong Kong

Yih‐Chung Tham

Singapore Eye Research Institute

Cooperative Institutions

Johns Hopkins University

390

National University of Singapore

264

Chinese University of Hong Kong

237

Singapore Eye Research Institute

221

Singapore National Eye Center

212

University College London

163

Duke-NUS Medical School

135

Sun Yat-sen University

115

National University Health System

112

University of Washington

105

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Smartphone-based Retinal Imaging to Characterize Early Functional Retinal Vascular Changes in Diabetic Retinopathy

Carol Y. Cheung Yumeng Wang John H.K. Liu Kenny H.W. Lai Robert T. Chang

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Citations (0)

Classification of SD-OCT volumes with multi pyramids, LBP and HOG descriptors: Application to DME detections

Khaled Alsaih G Lemaître Join Massich Vall Mojdeh Rastgoo Désiré Sidibé

This paper deals with the automated detection of Diabetic Macular Edema (DME) on Optical Coherence Tomography (OCT) volumes. Our method considers a generic classification pipeline with preprocessing for noise removal and flattening of each B-Scan. Features such as Histogram of Oriented Gradients (HOG) and Local Binary Patterns (LBP) are extracted and combined to create a set of different feature vectors which are fed to a linear-Support Vector Machines (SVM) Classifier. Experimental results show a promising sensitivity/specificity of 0.75/0.87 on a challenging dataset.

Local Binary Patterns

Flattening

10.1109/embc.2016.7590956

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Citations (27)

Gestational hypertensive disorders and retinal microvasculature: the Generation R Study

BMC Medicine (2017)

Laura Benschop Sarah Schalekamp‐Timmermans Jeanine E. Roeters van Lennep Vincent W.V. Jaddoe Tien Yin Wong

Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestational hypertensive disorders, such as pre-eclampsia and gestational hypertension, are related to the maternal retinal microvasculature status after pregnancy.This study is part of an ongoing population-based prospective cohort study. During pregnancy and 6.2 years after the index pregnancy (90% range 5.7-7.4 years), we examined 3391 women with available information on pre-eclampsia, gestational hypertension, and retinal vascular calibers. Retinal arteriolar and venular calibers were measured in the left eye from digitized retinal photographs.Women with pre-eclampsia had smaller retinal arteriolar calibers 6 years after pregnancy than women with a normotensive pregnancy (adjusted difference: -0.40 standard deviation score [SDS]; 95% confidence interval [CI]: -0.62, -0.19). For women with previous gestational hypertension, similar trends were observed (-0.20 SDS; 95% CI: -0.34, -0.05). With respect to retinal venular calibers, we did not observe consistent trends for women with previous pre-eclampsia. However, in women with previous gestational hypertension, we observed larger venular calibers (0.22 SDS; 95% CI: 0.07-0.36) than in women with a previous normotensive pregnancy. The association of gestational hypertensive disorders with retinal vessel calibers was mediated through mean arterial pressure at the time of retinal imaging.Compared to women with a previous normotensive pregnancy, women with pre-eclampsia and gestational hypertension show an altered status of the microvasculature 6 years after the index pregnancy. This is reflected by smaller retinal arteriolar calibers and wider retinal venular calibers. These microvascular changes may possibly contribute to the development of cardiovascular disease in later life.

Gestational hypertension

Generation R

10.1186/s12916-017-0917-2

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Citations (19)

Refractive Errors and Age-related Macular Degeneration: A Systematic Review and Meta-Analysis

Ophthalmology (2013)

Chen‐Wei Pan M. Kamran Ikram Carol Y. Cheung Hyungwon Choi Chui Ming Gemmy Cheung

Emmetropia

Cross-sectional study

10.1016/j.ophtha.2013.03.028

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Citations (49)

Prevalence And Risk Factors Of Epiretinal Membrane In An Asian Indian Population - Comparison With Another Ethnic Group

Investigative Ophthalmology & Visual Science (2011)

Victor Koh Carol Y. Cheung Wan Ling Wong Jie J. Wang Paul Mitchell

Epiretinal Membrane

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Influence of Refractive Error on Optic Disc Topographic Parameters: The Singapore Malay Eye Study

American Journal of Ophthalmology (2011)

Renyi Wu Tien Yin Wong Yingfeng Zheng Carol Y. Cheung Shamira Perera

Emmetropia

Optic disc

Optic disk

10.1016/j.ajo.2011.01.018

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Citations (25)

Retinal Vasculature Fractal Varies Between Glaucoma Subtypes in Asians: Insights into Underlying Vasculopathy

Investigative Ophthalmology & Visual Science (2011)

Gillian Teh Tien Yin Wong Erica Y. Liu Daniel Hsien-Wen Su Carol Y. Cheung

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Elevated Blood Pressure is Associated with Rarefaction of the Retinal Vasculature in Children

Investigative Ophthalmology & Visual Science (2011)

Emil Kurniawan Ning Cheung Carol Y. Cheung Wan Ting Tay Seang‐Mei Saw

Retinal vascular fractal dimension (D(f)) is a measure of the geometric complexity of the retinal microvasculature, and has been associated with diabetic retinopathy. In this study, the authors examined the relationship between blood pressure and retinal D(f) in children.Among 1174 children aged 10 to 14 years who participated in the Singapore Cohort Study of Risk Factors for Myopia, retinal D(f) was measured from digital fundus images using a computer-based program following a standardized protocol. Blood pressure was calculated from the average of three separate measurements in a seated position.The analysis shows that retinal D(f) was normally distributed, with a mean of 1.4619 (SD, 0.0144). After adjusting for age, sex, height, and retinal arteriolar and venular caliber, smaller retinal D(f) was correlated with elevated mean arterial blood pressure (P = 0.02), diastolic blood pressure (P = 0.02), and possibly systolic blood pressure (P = 0.06).Higher blood pressure in children is associated with smaller retinal D(f), reflecting rarefaction of the retinal microvasculature. Retinal fractal analysis detects early subtle microvascular effects of elevated blood pressure, and may further the understanding of the genesis of ocular and systemic vascular complications of hypertension.

Hypertensive retinopathy

Fundus (uterus)

10.1167/iovs.11-8835

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Citations (28)

Novel analysis of macular RNFL thickness in Alzheimer’s disease using OCT and point-wise functional shapes (FShape) registration

Investigative Ophthalmology & Visual Science (2018)

Sieun Lee Carol Y. Cheung Christopher Chen Tien Yin Wong Marinko V. Šarunic

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Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography

Asia-Pacific Journal of Ophthalmology (2012)

Carol Y. Cheung Noel C. Y. Chan Christopher Kai-Shun Leung

The objective of the study was to investigate the influence of signal strength (SS) on retinal nerve fiber layer (RNFL) measurement and interpretation of the RNFL thickness deviation map obtained with a spectral-domain optical coherence tomography.

Cirrus

10.1097/apo.0b013e31823e595d

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Citations (11)