Michal Rosenberg Friedman

Research Field

Abstract To study the effect of very advanced maternal age on perinatal outcomes. A retrospective cohort study of women aged 45 years and above, who delivered ≥22 weeks of gestation in a single tertiary center between 1/ 2011 and 12/ 2018. Maternal and neonatal outcomes were compared between women ≥50 years and women of 45–49 years at delivery. Of 83,661 parturients, 593 (0.7%) were 45–49 years old and 64 (0.07%) were ≥50 years old. Obstetrical characteristics were comparable, though the rate of chronic hypertension and preeclampsia with severe features were greater in women ≥50 years (6.2% vs 1.4%, p = 0.04, 15.6% vs 7.0%, p = 0.01, 95% CI 0.19–0.86, respectively). Elective cesarean deliveries were independently associated with advanced maternal age ≥50 (OR 2.63 95% CI 1.21–5.69). Neonatal outcomes were comparable for singletons, but rates of ventilatory support and composite severe neonatal outcomes were higher in twin pregnancies of women ≥50 years (42.8% vs 13.5%, p = 0.01, and 21.4% vs 4.0%, p = 0.03, respectively). Healthy women ≥50 have higher elective cesarean rates, despite similar maternal and neonatal characteristics.

Advanced maternal age

Chronic hypertension

10.1038/s41598-020-58583-6

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Citations (16)

A decision tree model for predicting live birth in FMR1 premutation carriers undergoing preimplantation genetic testing for monogenic/single gene defects

Reproductive BioMedicine Online (2021)

Yoni Cohen Noga Nattiv Sarit Avraham Yuval Fouks Michal Rosenberg Friedman

Live birth

FMR1

Preimplantation Genetic Diagnosis

10.1016/j.rbmo.2021.06.009

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Citations (2)

BNT162b2 COVID-19 mRNA vaccine elicits a rapid and synchronized antibody response in blood and milk of breastfeeding women

medRxiv (Cold Spring Harbor Laboratory) (2021)

Michal Rosenberg Friedman Aya Kigel Yael Bahar Yariv Yogev Yael Dror

We describe the dynamics of the vaccine-specific antibody response in the breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine. The antibody response was rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The predominant serum antibody was IgG. The response in the breastmilk included both IgG and IgA with neutralizing capacity.

Antibody response

2019-20 coronavirus outbreak

10.1101/2021.03.06.21252603

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Citations (25)

Mesenteric venous thrombosis associated with pregnancy and oral contraception. A case report.

PubMed (1987)

Graubard Zg Michal Rosenberg Friedman

Mesenteric vein thrombosis in a pregnant woman taking an oral contraceptive is reported. It is presumed that the hypercoagulable state of pregnancy combined with hormonal contraception led to the thrombosis.

Oral contraception

Source

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Citations (14)

Role of Zygote Intrafallopian Transfer as a Mode of Treatment for Repeated Implantation Failure in IVF in Patients with Tubal Infertility

Fertility and Sterility (2000)

Jacob Farhi Ariel Weissman H Nahum Z Shteinfeld Michal Rosenberg Friedman

Tubal factor infertility

Fallopian tube

Gamete intrafallopian transfer

10.1016/s0015-0282(00)01173-0

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