Satyajit Pradhan

Homi Bhabha National Institute

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Lalit Mohan Aggarwal

Institute of Medical Sciences

Gopeshwar Narayan

Banaras Hindu University

Sunita Singh

All India Institute of Medical Sciences

Sunil Choudhary

Institute of Medical Sciences

Divya Khanna

Advanced Centre for Treatment, Research and Education in Cancer

Suresh Singh Yadav

Guru Nanak Dev University

B. A. P. Tantry

Banaras Hindu University

Abhijit Mandal

Banaras Hindu University

Shyam Babu Prasad

M S Ramaiah University of Applied Sciences

Neeraj Sharma

Banaras Hindu University

Cooperative Institutions

Banaras Hindu University

125

Institute of Medical Sciences

103

Tata Memorial Hospital

Homi Bhabha National Institute

Advanced Centre for Treatment, Research and Education in Cancer

Indian Institute of Technology BHU

All India Institute of Medical Sciences

Bhabha Hospital

Creative Commons

Cancer Institute (WIA)

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VEGFa/VEGFR2 autocrine and paracrine signaling promotes cervical carcinogenesis via β-catenin and snail

The International Journal of Biochemistry & Cell Biology (2021)

Chandra Bhushan Prasad Deepika Singh Laxmi Pandey Satyajit Pradhan Sunita Singh

10.1016/j.biocel.2021.106122

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Citations (18)

STUDY OF SMALL-SCALE IRREGULARITIES IN F REGION AT VARANASI.

Shashank Kumar Srivastava Satyajit Pradhan B. A. P. Tantry

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Results of an open labeled prospective single group study of quality of life in patients with head neck cancer treated with paclitaxel based chemotherapy

S Karthikeyan Tushar Goyal Umakant Gaud Mridula Shukla Satyajit Pradhan

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5-Fluorouracil induces defects in platelet function

Platelets (1999)

Anand Kumar Rajeev Kumar Amitabh Sandilium Jyoti Shukla Satyajit Pradhan

Platelet factor-3 (PF3) availability and platelet aggregation to ADP (4 μmol/l) and adrenaline (1.2 μmol/1) were evaluated in patients being treated with 5-fluorouracil (5-FU) for gastrointestinal malignancy. It produced a significant reduction in platelet aggregation and platelet factor-3 (PF3) availability (P <0.001) without being associated with thrombocytopenia. The changes in platelet aggregation occurred during the first week of chemotherapy and continued with subsequent courses. This acquired abnormality may be responsible for a haemorrhagic diathesis even without obvious thrombocytopenia. Study of platelet function is important and may be considered to assess the haematological toxicity in patients being treated with systemic 5-FU therapy.

Bleeding diathesis

Abnormality

Diathesis

10.1080/09537109909169176

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A comparison of six fractions per week chemoradiation versus five fractions per week of conventional chemoradiation in carcinoma cervix: A prospective controlled study

Journal of Cancer Research and Therapeutics (2019)

Deepak Kumar Satyajit Pradhan Sunil Choudhary Lalit Mohan Aggarwal Avipsa Das

The standard of care for carcinoma cervix stage IB2-IVA is five fractions per week of radiotherapy (RT) with concurrent cisplatin. We compared the standard treatment with six fractions per week of RT with concurrent Cisplatin to see whether the later had improved survival outcomes with comparable toxicities.46 patients of carcinoma cervix with stage IB2-IVAwere randomized into two arms.Study arm: 46 Gy/23 fractions/26 days, 6 fractions/week with injection CDDP 40 mg/m2 and Control arm: 46 Gy/23 fractions/31 days, 5 fractions/week with injection Cisplatin 40mg/m2. Patients in both the arms received LDR brachytherapy to a dose of 29 Gy at point A.The primary end points were disease-free survival (DFS) and overall survival (OS). Compliance to treatment and treatment toxicities were the secondary end points. P value ≤0.05 were considered significant.The study was carried out during June, 2014-April, 2015. Statistical analysis was done in May, 2019. Of 46 patients, 39 patients completed the treatment. The study and control arms had 17 and 22 patients, respectively. Median follow-up period is 45 months (range: 1-54 months). 3-year DFS rates and OS was 69.5% vs. 72.7% (P = 0.73) and 63% vs. 68% (P = 0.45) in study and in control arm, respectively. There was no significant difference in acute and late radiation toxicities between two arms.Chemoradiotherapy with six fractions per week seems feasible and equally efficacious in terms of survival outcomes and toxicity profile. Further prospective randomized controlled study is required to prove the merit of altered fractionation with concurrent cisplatin.

Chemoradiotherapy

Clinical endpoint

10.4103/jcrt.jcrt_698_19

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Citations (1)

Study of unflattened photon beams shaped by multileaf collimator using BEAMnrc code

Journal of Radiotherapy in Practice (2016)

Ankit Kajaria Neeraj Sharma Shiru Sharma Satyajit Pradhan Abhijit Mandal

Abstract Purpose In our study basic dosimetric properties of a flattening filter free 6 MV photon beam shaped by multileaf collimators (MLC) is examined using the Monte Carlo (MC) method. Methods and Materials BEAMnrc code was used to make a MC simulation model for 6 MV photon beam based on Varian Clinic 600 unique performance linac, operated with and without a flattening filter in beam line. Dosimetric features including central axis depth dose, beam profiles, photon and electron spectra were calculated and compared for flattened and unflattened cases. Results Dosimetric field size and penumbra were found to be smaller for unflattened beam, and the decrease in field size was less for MLC shaped in comparison with jaw-shaped unflattened beam. Increase in dose rate of >2·4 times was observed for unflattened beam indicating a shorter beam delivery time for treatment. MLC leakage was found to decrease significantly when the flattening filter was removed from the beam line. The total scatter factor showed slower deviation with field sizes for unflattened beam indicating a reduced head scatter. Conclusions Our study demonstrated that improved accelerator characteristics can be achieved by removing flattening filter from beam line.

Multileaf collimator

Flattening

Collimator

10.1017/s1460396916000340

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Amplitude Probability Distribution of Radio Waves Reflected From Traveling Ionospheric Disturbances

Radio Science (1972)

S.K. Srivastava Satyajit Pradhan B. A. P. Tantry

In this paper, the amplitude distributions of the reflected radio waves, from various portions of the traveling ionospheric disturbances (TID) superimposed on small‐scale irregularities, have been studied with the help of simultaneous records of amplitude and phase patterns of vertically reflected echoes. Amplitude distributions of reflected waves, related to different small portions of TID are found to exhibit different types of well‐known distributions, like Rayleigh, Rice, and displaced Gaussian, while resultant distributions corresponding to two successive small portions of the TID may have different shapes, including the familiar M shape reported by many workers. Further, in some events, even three‐peaked amplitude distributions are observed depending upon the ratio of steady component to random component present in the received echo and the nature of the reflecting surface.

Rayleigh distribution

10.1029/rs007i005p00563

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HPV-type-specific response of cervical cancer cells to cisplatin after silencing replication licensing factor MCM4

Tumor Biology (2015)

Mitali Das Shyam Babu Prasad Suresh Singh Yadav Arusha Modi Sunita Singh

Minichoromosome maintenance (MCM) proteins play key role in cell cycle progression by licensing DNA replication only once per cell cycle. These proteins are found to be overexpressed in cervical cancer cells. In this study, we depleted MCM4, one of the MCM 2-7 complex components by RNA interference (RNAi) in four cervical cancer cell lines. The four cell lines were selected on the basis of their human papillomavirus (HPV) infection: HPV16-positive SiHa, HPV18-positive ME-180, HPV16- and HPV18-positive CaSki, and HPV-negative C-33A. The MCM4-deficient cells irrespective of their HPV status grow for several generations and maintain regular cell cycle. We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin. They show increased chromosomal instability compared to their control counterparts. On the other hand, MCM4-deficient CaSki cells (both HPV16+ and 18+) remain resistant to a prolonged exposure to cisplatin. Our study indicates that cervical cancer cells may be using excess MCMs as a backup for replicative stress; however, its regulatory mechanism is dependent on the HPV status of the cells.

Replication

10.1007/s13277-015-3782-7

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Citations (13)

114P Comparison of conventional and hypo fractionation radiation schedule on pulmonary function test in carcinoma of the breast as an acute effect

Annals of Oncology (2016)

K. Ibrahim A H.B. Govardhan Satyajit Pradhan P. Sridhar Rajeev Jain

Breast carcinoma

10.1016/s0923-7534(21)00273-8

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Determination of the gravity wave induced wind field with the help of phase path measurements

Satyajit Pradhan S. K. Srivastava

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