Umberto Galvalisi

Instituto de Investigaciones Biológicas Clemente Estable

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Sandra Lupo

Universidad de la República

Pablo Zunino

Instituto de Investigaciones Biológicas Clemente Estable

Juan Piccini

Universidad de la República

Lina Bettucci

Universidad de la República

Paola Scavone

Instituto de Investigaciones Biológicas Clemente Estable

Rafael Pellegrino

Instituto de Investigaciones Biológicas Clemente Estable

Vanessa Sosa

Instituto de Investigaciones Biológicas Clemente Estable

Paula Lagurara

Universidad de la República

Paola Iccardi

Instituto de Investigaciones Biológicas Clemente Estable

Gastón Azzíz

Universidad de la República

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Instituto de Investigaciones Biológicas Clemente Estable

Ministerio de Educación y Cultura

Universidad de la República

Universidad de Montevideo

Universidad La República

Animal, Santé, Territoires, Risques et Ecosystèmes

Observatorio Astronómico Los Molinos

Centro Nacional de Biotecnología

Consejo Superior de Investigaciones Científicas

Center for Systems Biology

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Penicillium species present in Uruguayan salami Especies de Penicillium presentes en salamines uruguayos

DOAJ (DOAJ: Directory of Open Access Journals) (2012)

Umberto Galvalisi Sandra Lupo Juan Piccini Lina Bettucci

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Mucosal vaccination of mice with recombinant Proteus mirabilis structural fimbrial proteins

Microbes and Infection (2004)

Paola Scavone Vanessa Sosa Rafael Pellegrino Umberto Galvalisi Pablo Zunino

10.1016/j.micinf.2004.04.006

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Citations (41)

Native legumes of the Farrapos protected area in Uruguay establish selective associations with rhizobia in their natural habitat

Soil Biology and Biochemistry (2020)

Marianoel Pereira‐Gomez Cecilia Ríos María Zabaleta Paula Lagurara Umberto Galvalisi

Mesorhizobium

Bradyrhizobium

10.1016/j.soilbio.2020.107854

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Evaluation ofProteus mirabilisstructural fimbrial proteins as antigens against urinary tract infections

FEMS Immunology & Medical Microbiology (2003)

Rafael Pellegrino Umberto Galvalisi Paola Scavone Vanessa Sosa Pablo Zunino

Proteus mirabilis is a common cause of urinary tract infection (UTI) and produce several types of different fimbriae, including mannose-resistant/Proteus-like fimbriae, uroepithelial cell adhesin (UCA), and P. mirabilis fimbriae (PMF). Different authors have related these fimbriae with different aspects of P. mirabilis pathogenesis, although the precise role of fimbriae in UTI has not yet been elucidated. In this work we expressed and purified recombinant structural fimbrial proteins of these fimbriae (MrpA, UcaA, and PmfA) and assessed their role as protective antigens using an ascending and a haematogenous model of UTI in the mouse. MrpA protected subcutaneously immunised mice in both models, suggesting that it could be taken into account as a promising vaccine candidate against P. mirabilis UTI. UcaA could also be an interesting subunit to be studied although it only protected mice that were challenged intravenously. All subunits elicited a strong specific serum IgG response but there was no significant correlation between antibody levels and protection. Only PmfA-immunised mice elicited a significant urinary antibody response but this protein was unable to confer protection against P. mirabilis experimental challenges. These results may contribute to the development of vaccines against P. mirabilis, an important cause of complicated UTI.

10.1016/s0928-8244(03)00103-2

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Penicillium species present in Uruguayan salami.

PubMed (2012)

Umberto Galvalisi Sandra Lupo Juan Piccini Lina Bettucci

Patulin

Water activity

Moho

Starter

10.1590/s0325-75412012000100008

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Citations (20)