Francis Keuppens

Queen Fabiola Children's University Hospital

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L. Denis

Ziekenhuisnetwerk Antwerpen Stuivenberg

Antoine De Backer

Universitair Ziekenhuis Brussel

J. M. Limbosch

Centre hospitalier Etterbeek-Ixelles

B. Vergison

European Organisation for Research and Treatment of Cancer

G. Viggiano

Azienda Unita' Sanitaria Locale Di Modena

Meyer R. Robinson

Marie-Claire Woussen Colle

Brigitte Cheuvart

GlaxoSmithKline (Belgium)

G. Willems

Vrije Universiteit Brussel

Ch. Bouffioux

University of Liège

Cooperative Institutions

European Organisation for Research and Treatment of Cancer

Vrije Universiteit Brussel

European Organisation for Research and Treatment of Cancer

Universitair Ziekenhuis Brussel

Centre Hospitalier Universitaire de Saint-Pierre

Academic Medical Center

Queen Fabiola Children's University Hospital

Université Libre de Bruxelles

Ghent University Hospital

University of Amsterdam

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Effect of feeding on catabolism and activity of exogenous gastrin in dogs.

PubMed (1976)

Marie-Claire Woussen Colle J. M. Limbosch Francis Keuppens Jacques De Graef

The effect of meal upon the catabolism and activity of exogenous gastrin was tested in 4 antrectomized and 4 non antrectomized dogs with Heidenhain pouches. In both antrectomized and non antrectomized dogs infused with exogenous gastrin, the meal decreased the serum gastrin level. This decrease amounted to about 20%, 60 minutes after feeding and the gastrinemia then returned gradually to control levels. In non antrectomized dogs, infusion of a near maximal dose of gastrin increased the acid response to the meal to a level above the maximal histamine acid output. Exogenous gastrin also increased the acid response to a meal in antrectomized dogs. These data indicate: 1) That feeding increases the metabolic clearance rate of exogenous gastrin. This effect could be at least partly related to changes in the intestinal blood flow. 2) That, after feeding, one or several hormones capable of stimulating the acid secretion but unrelated to gastrin are probably released. These hormones could be of major importance in the response of denervated pouches to feeding.

Catabolism

Gastrointestinal hormone

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Bilateral Wilms' tumor: In situ cooling of the kidney facilitates curative excision of tumors, with preservation of renal function

Journal of Pediatric Surgery (1995)

Antoine De Backer Jan Lamote Francis Keuppens G. Willems J. Otten

Renal parenchyma

Parenchyma

10.1016/0022-3468(95)90499-9

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Citations (22)

Mitomycin C therapy in superficial bladder cancer.

PubMed (1985)

L. Denis Francis Keuppens Gretl Hendrickx

Mitomycin C

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Citations (3)

An III study comparing orchidectomy (Ctr) and orchidectomy plus mitomycin C (Exp: 15 mg/m2 intravenously q6 wks until progression) with respect to quality of life In patients with poor prognosis M1 prostate cancer

European Journal of Cancer (1997)

Sophie D. Fosså Dominic Curran Francis Keuppens J. Kliment Meyer R. Robinson

Mitomycin C

10.1016/s0959-8049(97)84504-2

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Citations (1)

Adjuvant Chemotherapy of Recurrent Superficial Transitional Cell Carcinoma: Results of a European Organization for Research on Treatment of Cancer Randomized Trial Comparing Intravesical Instillation of Thiotepa, Doxorubicin and Cisplatin

The Journal of Urology (1992)

Ch. Bouffioux L. Denis W. Oosterlinck G. Viggiano B. Vergison

No AccessJournal of Urology1 Aug 1992Adjuvant Chemotherapy of Recurrent Superficial Transitional Cell Carcinoma: Results of a European Organization for Research on Treatment of Cancer Randomized Trial Comparing Intravesical Instillation of Thiotepa, Doxorubicin and Cisplatin Ch. Bouffioux, L. Denis, W. Oosterlinck, G. Viggiano, B. Vergison, F. Keuppens, M. De Pauw, R. Sylvester, B. Cheuvart, and Members of the European Organization For Research on Treatment of Cancer Genitourinary Group Ch. BouffiouxCh. Bouffioux More articles by this author , L. DenisL. Denis More articles by this author , W. OosterlinckW. Oosterlinck More articles by this author , G. ViggianoG. Viggiano More articles by this author , B. VergisonB. Vergison More articles by this author , F. KeuppensF. Keuppens More articles by this author , M. De PauwM. De Pauw More articles by this author , R. SylvesterR. Sylvester More articles by this author , B. CheuvartB. Cheuvart More articles by this author , and Members of the European Organization For Research on Treatment of Cancer Genitourinary Group More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36577-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A total of 356 patients with recurrent superficial transitional cell carcinoma of the bladder was entered in a randomized clinical trial to compare intravesical thiotepa, doxorubicin and cisplatin with respect to the recurrence rate and disease-free interval. After complete transurethral resection of all visible lesions, the drugs were administered weekly for 4 weeks and monthly for 11 months. The recurrence rates per year were 0.50 for thiotepa, 0.54 for doxorubicin and 0.58 for cisplatin. Of 266 patients (mean followup 41 months) 35 reported an increase in T category and 19 of them had distant metastases. No association between treatment and progression was noted. Thus, there is no difference among treatments with respect to efficacy. However, severe anaphylactic reactions were observed in the cisplatin arm and chemical cystitis was more frequently reported in patients who received doxorubicin. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byVásquez J, Ibsen P, Lindberg H and Gehl J (2018) In Vitro and In Vivo Experiments on Electrochemotherapy for Bladder CancerJournal of Urology, VOL. 193, NO. 3, (1009-1015), Online publication date: 1-Mar-2015.Kurth K, Tunn U, Ay R, Schroder F, Pavone-Macaluso M, Debruyne F, Ten Kate F, De Pauw M and Sylvester R (2018) Adjuvant Chemotherapy for Superficial Transitional Cell Bladder Carcinoma: Long-term Results of a European Organization for Research and Treatment of Cancer Randomized Trial Comparing Doxorubicin, Ethoglucid and Transurethral Resection AloneJournal of Urology, VOL. 158, NO. 2, (378-384), Online publication date: 1-Aug-1997. (2018) EDITORIAL COMMENTJournal of Urology, VOL. 158, NO. 1, (73-74), Online publication date: 1-Jul-1997. (2018) EDITORIAL COMMENTJournal of Urology, VOL. 158, NO. 6, (2077-2077), Online publication date: 1-Dec-1997.Krege S, Giani G, Meyer R, Otto T and Rubben H (2018) A Randomized Multicenter Trial of Adjuvant Therapy in Superficial Bladder Cancer: Transurethral Resection Only Versus Transurethral Resection Plus Mitomycin C Versus Transurethral Resection Plus Bacillus Calmette-GuerinJournal of Urology, VOL. 156, NO. 3, (962-966), Online publication date: 1-Sep-1996.Pawinski A, Sylvester R, Kurth K, Bouffioux C, Van Der Meijden A, Parmar M and Bijnens L (2018) A Combined Analysis of European Organization for Research and Treatment of Cancer, and Medical Research Council Randomized Clinical Trials for the Prophylactic Treatment of Stage TaT1 Bladder CancerJournal of Urology, VOL. 156, NO. 6, (1934-1941), Online publication date: 1-Dec-1996. Volume 148Issue 2 Part 1August 1992Page: 297-301 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordscarcinomathiotepadoxorubicintransitional cellbladder neoplasmscisplatinMetricsAuthor Information Ch. Bouffioux More articles by this author L. Denis More articles by this author W. Oosterlinck More articles by this author G. Viggiano More articles by this author B. Vergison More articles by this author F. Keuppens More articles by this author M. De Pauw More articles by this author R. Sylvester More articles by this author B. Cheuvart More articles by this author Members of the European Organization For Research on Treatment of Cancer Genitourinary Group More articles by this author Expand All Advertisement PDF downloadLoading ...

ThioTEPA

10.1016/s0022-5347(17)36577-1

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Citations (58)