Objective Collapse of the maxillary minor segment with lateral crossbite is a common feature in patients with repaired unilateral cleft lip/palate because of maxillary alveolar bony defect and palatal scar tissue. Distraction osteogenesis (DOG) is an effective technique of lengthening and augmentation for bone and gingiva. This case report describes the effects of unilateral advancement of the maxillary minor segment by DOG in two patients with the repaired unilateral cleft lip/palate.
Secretory carcinoma of the breast: a tumour analogous to salivary gland acinic cell carcinoma? Aims : Acinic cell‐like breast carcinoma is a newly recognized entity, and few acinic cell‐like breast carcinoma cases have been reported. All reported acinic cell‐like breast carcinomas were counterparts of the solid type of acinic cell carcinoma of the salivary gland. We report here three cases of secretory breast carcinoma with acinic cell differentiation, and discuss the similarity between secretory breast carcinoma and acinic cell carcinoma of the salivary gland. Methods and results : The cases were histologically identical to acinic cell carcinoma of the salivary gland: papillary‐cystic type in case 1, a mixture of papillary‐cystic, microcystic and follicular type in case 2, and microfollicular type in case 3. Immunohistochemically, the tumour cells were positive for salivary‐type amylase, lysozyme, S100 protein and α 1 ‐antitrypsin, and negative or less reactive for gross cystic disease fluid protein‐15 and oestrogen receptor. All three cases did not reveal metastasis or recurrence. Conclusions : These cases were typical of secretory breast carcinoma, and were clinically, histologically and immunohistochemically analogous to acinic cell carcinoma of the salivary gland. We emphasize that secretory breast carcinoma and acinic cell carcinoma of the salivary gland may be identical lesions.
We evaluated the efficacy of chemoradiotherapy (CRT) for advanced esophageal cancer, from the view point of response. The relationship between chemo-radiosensitivity and dihydropyridine dehydrogenase (DPD), thymidylate synthase (TS), and p53 was investigated immunohistochemically. Thirteen patients with inoperable advanced esophageal cancer were involved in this study. CDDP of 10 mg/m2/day and 5-FU of 335 mg/m2/day were infused intravenously (day 1-5, day 15-19). Radiation was delivered concomitantly at a total dose of 30 Gy. Expressions of p53, DPD and TS were detected using immunohistology in the biopsy samples taken before CRT from 8 patients. Partial response was observed in 8 cases, no change in 4 cases, and progressive disease in one case. The overall response rate was 62%. The reduction rate was higher in tumors positive for p53 expression than in negative ones. The same was true for DPD and TS. The Treatment effect was more precisely predicted by combination of p53, DPD and TS. CRT with low-dose CDDP + 5-FU chemotherapy was effective and combination with p53, DPD, and TS might be a predictive marker for CRT in patients with advanced esophageal cancer.
A case of osteosarcoma occurring in the mandible of 48-year-Dld man was presented. At first visit, clinical diagnosis was osteomyelitis, and the diagnosis of osteosarcoma was done by biopsy.He underwent radical operation (hemimandibulectomy and reconstruction with D-P flap), before and after which high-dose methotrexate therapy (100mg-300mg/kg) was carried out.There is no evidence of recurrence till now.
Garré's osteomyelitis of the jaw is a unique clinicopathologic entity that is characterized by asymptomatic focal osteomyelitis and exuberant periosteal deposition of bone. Odontodysplasia is a rare developmental anomaly of tooth formation in young children. Its causes remain unknown.A 9 -year-old boy presented for evaluation of a painless swelling in the right side of the mandible. The swelling was bone hard and nonfluctutant. Intraoral examination showed partial obliteration of the mucobuccal fold by a bony mass, and the erupted lower right second premolar was malformed. Several kinds of X-ray examinations revealed proliferative periostitis with new bone formation. In addition, the lower right second premolar showed a so-called ghost-like appearance radiographically. Biopsy of the periosteal mass was performed, and the histopathologic diagnosis was reactive bone formation of the periosteum.In this rare case, the periosteal bony reaction in the mandible was successfully treated by tooth extraction with curettage and antibiotic therapy.Osteomyelitis in our patient might have been caused by dental caries of the deciduous lower right second molar. Odontodysplasia resulted from periapical inflammation of the deciduous lower right second molar subsequent to osteomyelitis with periostitis.
The clinical features of perioral molluscum contagiosum in a patient with the acquired immunodeficiency syndrome are described. Light microscopy and thin section electron microscopy revealed epidermal cells in different stages of degeneration showing two types of cytoplasmic inclusions. The basement membrane exhibited discontinuities and multiple laminations which may be a response to viral‐induced cytotoxic effects.
