Xiao-Qi Gao

Shanghai Veterinary Research Institute

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Yongli Xu

Liaoning Shihua University

Zhiyong Ma

Shanghai Veterinary Research Institute

Zixue Shi

Chinese Academy of Agricultural Sciences

Yafeng Qiu

Chinese Academy of Agricultural Sciences

Jianhua Miao

Guangxi Medicinal Botanical Garden

Lina Peng

Yangtze Normal University

Donghua Shao

Shanghai Veterinary Research Institute

Ying Zhou

Beijing Normal University

Jianchao Wei

Shanghai Veterinary Research Institute

Li Li

Yunnan Provincial Department of Education

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Shanghai Veterinary Research Institute

Chinese Academy of Agricultural Sciences

Guangxi Medicinal Botanical Garden

Chinese Academy of Agricultural Engineering

Hunan Agricultural University

Capital Medical University

Liaoning Shihua University

North China University of Science and Technology

Huazhong University of Science and Technology

Sun Yat-sen University

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Glycyrrhetinic acid extracted fromGlycyrrhiza uralensisFisch. induces the expression of Toll-like receptor 4 in Ana-1 murine macrophages

Journal of Asian Natural Products Research (2011)

Lina Peng Li Li Yafeng Qiu Jianhua Miao Xiao-Qi Gao

Glycyrrhetinic acid (GA) is an active component of licorice root that has long been used as a herbal medicine for the treatment of peptic ulcer, hepatitis, and pulmonary and skin diseases in Asia and Europe. In this study, we analyzed the effect of GA extracted from Glycyrrhiza uralensis Fisch. on the expression of Toll-like receptors (TLRs) that play key roles in regulating the innate immune response against invading pathogens. Stimulation of Ana-1 murine macrophages with GA induced a significant dose-dependent expression of TLR-4, and its mRNA expression that increased from 3-h post-treatment was approximately fivefold over the level in the mock-treated cells. No endotoxin contamination contributed to the GA-induced TLR-4 expression, because polymyxin B treatment did not alter the upregulated expression of TLR-4 in GA-treated cells. Several molecules, such as myeloid differentiation factor 88, interferon-β, and interleukin-6, which are involved in the TLR-4 downstream signaling pathway, were upregulated significantly in response to GA stimulation. Our findings demonstrate that GA is able to induce the expression of TLR-4 and activate its downstream signaling pathway.

Glycyrrhiza uralensis

Glycyrrhiza

10.1080/10286020.2011.603305

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Icariin induces the Expression of Toll‐like Receptor 9 in Ana‐1 Murine Macrophages

Phytotherapy Research (2011)

Li Li Lina Peng Jianhua Miao Yafeng Qiu Ying Zhou

Icariin is the major pharmacologically active compound of Herba epimedii which has been used as a tonic, aphrodisiac and an antirheumatic in traditional Chinese medicine. This study analysed the effect of icariin on the expression of Toll-like receptor 9 (TLR9) which plays an important role in regulation of the innate immune response. Stimulation of Ana-1 murine macrophages with icariin induced a significant dose-dependent expression of TLR9, and its mRNA expression which increased from 3 h post-treatment was approximately five-fold that of DMSO-treated cells. Several molecules, such as myeloid differentiation factor 88, tumor necrosis factor-α and interleukin 6, which are involved in the TLR9 downstream signaling pathway, were also significantly up-regulated in response to icariin stimulation. Our findings demonstrated that icariin is able to induce the expression of TLR9.

Icariin

TLR9

10.1002/ptr.3514

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