Susan L. Raghoobar

Merck & Co., Inc., Rahway, NJ, USA (United States)

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Katherine Young

Merck & Co., Inc., Rahway, NJ, USA (United States)

Milton L. Hammond

Merck & Co., Inc., Rahway, NJ, USA (United States)

Michael Goetz

University Hospital Ulm

Timothy A. Blizzard

Merck & Co., Inc., Rahway, NJ, USA (United States)

Ronald E. Painter

Quantitative BioSciences

Nichelle Hairston

Merck & Co., Inc., Rahway, NJ, USA (United States)

Young-Whan Park

National Cancer Center

Gerald F. Bills

The University of Texas Health Science Center at Houston

Fernando Peláez

Municipality of Medellín

Paula M.D. Fitzgerald

Merck & Co., Inc., Rahway, NJ, USA (United States)

Cooperative Institutions

Merck & Co., Inc., Rahway, NJ, USA (United States)

Merck (Japan)

United States Military Academy

MSD (Spain)

Rutgers, The State University of New Jersey

MSD K.K. (Japan)

Harvard University

New York Botanical Garden

Merck Institute for Science Education

Karo Pharma (Sweden)

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In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

BMC Microbiology (2019)

Katherine Young Ronald E. Painter Susan L. Raghoobar Nichelle Hairston Fred Racine

The prevalence of antibiotic resistance is increasing, and multidrug-resistant Pseudomonas aeruginosa has been identified as a serious threat to human health. The production of β-lactamase is a key mechanism contributing to imipenem resistance in P. aeruginosa. Relebactam is a novel β-lactamase inhibitor, active against class A and C β-lactamases, that has been shown to restore imipenem susceptibility. In a series of studies, we assessed the interaction of relebactam with key mechanisms involved in carbapenem resistance in P. aeruginosa and to what extent relebactam might overcome imipenem non-susceptibility.

Parasitology

10.1186/s12866-019-1522-7

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Citations (93)

L-741,494, a Fungal Metabolite That Is an Inhibitor of Interleukin-1β Converting Enzyme

Journal of Natural Products (1994)

Michael J. Salvatore Otto D. Hensens Deborah L. Zink Jerrold M. Liesch Claude Dufresne

gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.

10.1021/np50108a011

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Citations (26)

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

Bioorganic & Medicinal Chemistry Letters (2014)

Timothy A. Blizzard Helen Chen Seongkon Kim Jane Y. Wu Rena Bodner

Piperidine

10.1016/j.bmcl.2013.12.101

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Citations (152)

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem

Bioorganic & Medicinal Chemistry Letters (2009)

Timothy A. Blizzard Helen Chen Seongkon Kim Jane Y. Wu Katherine Young

10.1016/j.bmcl.2009.12.069

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Citations (30)

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712

Bioorganic & Medicinal Chemistry Letters (2011)

Helen Chen Timothy A. Blizzard Seongkon Kim Jane Y. Wu Katherine Young

Side chain

Chain (unit)

10.1016/j.bmcl.2011.05.065

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Citations (22)

Sphingofungins F and F: Novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii.

The Journal of Antibiotics (1992)

Wendy S. Horn Jack L. Smith Gerald F. Bills Susan L. Raghoobar Gregory L. Helms

Paecilomyces

Peptidyl transferase

Transferase

10.7164/antibiotics.45.1692

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Citations (119)

ChemInform Abstract: Isolation and Structure of Flutimide, a Novel Endonuclease Inhibitor of Influenza Virus.

ChemInform (1995)

Otto D. Hensens Michael Goetz Jerrold M. Liesch Deborah L. Zink Susan L. Raghoobar

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Isolation

10.1002/chin.199530270

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Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii

Bioorganic & Medicinal Chemistry Letters (2011)

Qiang Tan Aimie M. Ogawa Susan L. Raghoobar Douglas Wisniewski Lawrence F. Colwell

Acinetobacter baumannii

Enterobacter cloacae

10.1016/j.bmcl.2011.04.122

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Citations (7)