Zohre Khorshidvand

Urmia University of Medical Sciences

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Khosrow Hazrati Tappeh

Urmia University of Medical Sciences

Shahram Shahabi

Eli Lilly (United Kingdom)

Habib Mohammadzadeh

Urmia University of Medical Sciences

Habib Mohamadzade

Urmia University

Ahmad Daryani

Mazandaran University of Medical Sciences

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Urmia University of Medical Sciences

Urmia University

Birjand University of Medical Sciences

Mazandaran University of Medical Sciences

Scientific Center of Zoology and Hydroecology

Riphah International University

National Academy of Sciences of Armenia

Institute for Health Metrics and Evaluation

University of Washington

University of California, Davis

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A Novel Adjuvant, Mixture of Alum And Naltrexone, Elicits Humoral Immune Responses for excreted/secreted Antigens of Toxoplasma gondii Tachyzoites Vaccine In Balb/c Murine Model Balb/c Fare Modelinde Alum ve Naltrexone Adjuvan Karişimi Kullanilarak, Toxoplasma gondii Takizoitlerinin ekskratuvar/sekretuvar Antijenleriyle Hazirlanmiş Aşinin Humoral İmmun Yaniti Uyarmasi

Khosrow Hazrati Tappeh Zohre Khorshidvand Shahram Shahabi Habib Mohammadzadeh

Objective: The excreted-secreted antigens (ESA) from the tachyzoites seem to play a key role in immunity against Toxoplasma gondii. The aim of this study is to investigate whether Alum-NLT mixture, as a new adjuvant, can induce humoral immunity in response to excretedsecreted antigens (ESA) of Toxoplasma gondii as a model vaccine or not. Methods: Six- to eight-week-old female Balb/c mice were divided into five groups. Mice in the experimental groups received either ESA vaccine alone or in combination with the adjuvant Alum, NLT or Alum-NLT mixture; Mice in the negative control group received phosphate buffered saline (PBS). All mice were immunised, three times subcutaneously (s.c.) with a total volume of 150µl each with a 10-day interval. Ten days after the final immunisation, immune response to Toxoplasma gondii was assessed. Results: Our results revealed that Alum-NLT mixture as an adjuvant during vaccination boosts the efficacy of the ESA vaccine by means of increasing Toxoplasma gondii-specific IgG, IgG2a production and the ratio of IgG2a/IgG1 (P-value < 0.05). The use of this adjuvant mixture improved the protective immunity against Toxoplasma gondii. Conclusion: Administration of the Alum-NLT mixture as an adjuvant in ESA vaccine enhances humoral immunity. (Turkiye Parazitol Derg 2013; 37: 92-6)

Alum

Humoral immunity

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Mixture of Alum – Naloxone and Alum – Naltrexone as a novel adjuvant elicits immune responses for Toxoplasma gondii lysate antigen in BALB /c mice

Experimental Parasitology (2016)

Zohre Khorshidvand Shahram Shahabi Habib Mohamadzade Ahmad Daryani Khosrow Hazrati Tappeh

Alum

10.1016/j.exppara.2016.01.001

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A Novel Adjuvant, Mixture of Alum And Naltrexone, Elicits Humoral Immune Responses for excreted/secreted Antigens of Toxoplasma gondii Tachyzoites Vaccine In Balb/c Murine Model

Turkish Journal of Parasitology (2013)

Khosrow Hazrati Tappeh Zohre Khorshidvand Shahram Shahabi Habib Mohammadzadeh

Objective: The excreted-secreted antigens (ESA) from the tachyzoites seem to play a key role in immunity against Toxoplasma gondii.The aim of this study is to investigate whether Alum-NLT mixture, as a new adjuvant, can induce humoral immunity in response to excretedsecreted antigens (ESA) of Toxoplasma gondii as a model vaccine or not.Methods: Six-to eight-week-old female Balb/c mice were divided into five groups.Mice in the experimental groups received either ESA vaccine alone or in combination with the adjuvant Alum, NLT or Alum-NLT mixture; Mice in the negative control group received phosphate buffered saline (PBS).All mice were immunised, three times subcutaneously (s.c.) with a total volume of 150µl each with a 10-day interval.Ten days after the final immunisation, immune response to Toxoplasma gondii was assessed.Results: Our results revealed that Alum-NLT mixture as an adjuvant during vaccination boosts the efficacy of the ESA vaccine by means of increasing Toxoplasma gondii-specific IgG, IgG2a production and the ratio of IgG2a/IgG1 (P-value < 0.05).The use of this adjuvant mixture improved the protective immunity against Toxoplasma gondii.Conclusion: Administration of the Alum-NLT mixture as an adjuvant in ESA vaccine enhances humoral immunity.

Alum

Humoral immunity

Toxoplasmosis

10.5152/tpd.2013.22

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Citations (12)