Bezhan Chankvetadze

Tbilisi State University

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Gottfried Blaschke

University of Münster

Tivadar Farkas

Tbilisi State University

Salvatore Fanali

University of Verona

Yoshio Okamoto

Nagoya University

Lali Chankvetadze

Tbilisi State University

Jacques Crommen

University of Liège

Antonio Salgado

Universidad de Alcalá

Paola Peluso

Istituto di Chimica Biomolecolare

Naira Burjanadze

University of Münster

Marianne Fillet

University of Liège

Cooperative Institutions

Tbilisi State University

Sokhumi State University

University of Münster

Sapienza University of Rome

National Research Council

Instituto de Investigación en Ciencias de la Alimentación

Consejo Superior de Investigaciones Científicas

Institute of Environmental Assessment and Water Research

Marche Polytechnic University

University of Bologna

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Mechanistic study of opposite migration order of dimethindene enantiomers in capillary electrophoresis in the presence of native β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin

Journal of Chromatography A (2000)

Bezhan Chankvetadze Giorgio Pintore Naira Burjanadze Dieter Bergenthal Klaus Bergander

Moiety

Beta-Cyclodextrins

Stoichiometry

10.1016/s0021-9673(00)00146-1

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Citations (56)

Chiral Compounds

CRC Press eBooks (2009)

Bezhan Chankvetadze

10.1201/noe1420084597.ch80

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Citations (2)

Evaluation of core-shell stationary phases in capillary electrochromatography for their potential to separate chiral pharmaceutical compounds.

Sven Declerck Bezhan Chankvetadze Yvan Vander Heyden Debby Mangelings

Electrochromatography

Source

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Citations (0)

Electrophoresis on Enantioseparations 2024

Electrophoresis (2024)

Bezhan Chankvetadze

10.1002/elps.202470064

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Citations (0)

Separation of enantiomers of norephedrine by capillary electrophoresis using cyclodextrins as chiral selectors: Comparative CE and NMR studies

Electrophoresis (2012)

Ketevan Lomsadze Elena Domínguez‐Vega Antonio Salgado Antonio L. Crego Gerhard K. E. Scriba

In this study, the enantiomer migration order ( EMO ) of norephedrine ( NEP ) in the presence of various CD s was investigated by CE . NMR and CE techniques were used to analyze the mechanism of the chiral recognition between NEP enantiomers and four CD s, i.e., native α‐ CD , β‐ CD , heptakis(2,3‐di‐O‐acetyl‐6‐O‐sulfo)‐β‐ CD ( HDAS ‐β‐ CD ), and heptakis(2,3‐di‐O‐methyl‐6‐O‐sulfo)‐β‐ CD (HDMS‐β‐ CD ). EMO was reversed in the presence of α‐ CD and β‐ CD , although only minor differences in the structures of the complexes formed between NEP and these CD s could be derived from rotating frame nuclear Overhauser experiments ( ROESY ). The complexes between the enantiomers of NEP and the sulfated CD s, HDMS‐β‐ CD , and HDAS ‐β‐ CD , were substantially different. However, EMO of NEP was identical in the presence of these CD s. HDAS ‐β‐ CD proved to be the most suitable chiral selector for the CE enantioseparation of NEP .

Chirality

Proton NMR

10.1002/elps.201200062

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Citations (46)

Enantioseparation of selected chiral sulfoxides in high-performance liquid chromatography with polysaccharide-based chiral selectors in polar organic mobile phases with emphasis on enantiomer elution order

Journal of Separation Science (2014)

Maia Gegenava Lali Chankvetadze Tivadar Farkas Bezhan Chankvetadze

The separation of the enantiomers of 17 chiral sulfoxides was studied on polysaccharide-based chiral columns in polar organic mobile phases. Enantiomer elution order (EEO) was the primary objective in this study. Two of the six chiral columns, especially those based on amylose tris(3,5-dimethylphenylcarbamate) and cellulose tris(4-chloro-3-methylphenylcarbamate) (Lux Cellulose-4) proved to be most successful in the separation of the enantiomers of the studied sulfoxides. Interesting examples of EEO reversal were observed depending on the chiral selector or the composition of the mobile phase. For instance, the R-(+) enantiomer of lansoprazole eluted before the S-(−) enantiomer on Lux Cellulose-1 in both methanol or ethanol as the mobile phase, while the elution order was opposite in the same eluents on amylose tris(3,5-dimethylphenylcarbamate) with the S-(−) enantiomer eluting before the R-(+) enantiomer. The R-(+) enantiomer of omeprazole eluted first on Lux Amylose-2 in methanol but it was second when acetonitrile was used as the mobile phase with the same chiral selector. Several other examples of reversal in EEO were observed in this study. An interesting example of the separation of four stereoisomers of phenaminophos sulfoxide containing chiral sulfur and phosphor atoms is also reported here.

Chiral derivatizing agent

Sulfoxide

Racemization

10.1002/jssc.201301318

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Citations (41)

Contributors

Elsevier eBooks (2013)

A. Alfonso Jeanethe Anguizola ‪Damià Barceló Geoffrey S. Baird Kimber L. Barnett

10.1016/b978-0-12-415806-1.01002-0

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High-performance liquid chromatographic separations of stereoisomers of chiral basic agrochemicals with polysaccharide-based chiral columns and polar organic mobile phases

Journal of Separation Science (2015)

Iza Matarashvili Iamze Shvangiradze Lali Chankvetadze Shota Sidamonidze Nino Takaishvili

The separation of the stereoisomers of 23 chiral basic agrochemicals was studied on six different polysaccharide-based chiral columns in high-performance liquid chromatography with various polar organic mobile phases. Along with the successful separation of analyte stereoisomers, emphasis was placed on the effect of the chiral selector and mobile phase composition on the elution order of stereoisomers. The interesting phenomenon of reversal of enantiomer/stereoisomer elution order function of the polysaccharide backbone (cellulose or amylose), type of derivative (carbamate or benzoate), nature, and position of the substituent(s) in the phenylcarbamate moiety (methyl or chloro) and the nature of the mobile phase was observed. For several of the analytes containing two chiral centers all four stereoisomers were resolved with at least one chiral selector/mobile phase combination.

Chiral derivatizing agent

Moiety

Chirality

10.1002/jssc.201500919

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Citations (35)

History, advancement, bottlenecks, and future of chiral capillary electrochromatography

Journal of Chromatography A (2020)

Salvatore Fanali Bezhan Chankvetadze

10.1016/j.chroma.2020.461832

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Citations (41)

Recent Trends in Enantioseparation of Chiral Drugs

Methods and principles in medicinal chemistry (2003)

Bezhan Chankvetadze

Introduction Current Status in the Development and use of Chiral Drugs The Role of Separation Techniques in Chiral Drug Development, Investigation and Use Preparation of Enantiomerically Pure Drugs Resolution of Racemates Chiral Pool Catalytic Asymmetric Synthesis Chromatographic Techniques SMB Other Chromatographic and Electrophoretic Techniques for the Preparation of Enantiomers Bioanalysis of Chiral Drugs GC HPLC CE CEC Future Trends References

Bioanalysis

Chiral stationary phase

Chiral derivatizing agent

10.1002/3527602666.ch7

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Citations (1)