E. Boiret

Établissement Français du Sang

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Françoise Bouchardeau

Institut National de la Transfusion Sanguine

Patrick Maisonneuve

European Institute of Oncology

M.H. Elghouzzi

Sorbonne Université

C. Tirtaine

Centre de Recherche sur les Identités, les Nations et l'Interculturalité

Josiane Pillonel

Santé Publique France

Valérie Barlet

Établissement Français du Sang

AM Couroucé

Université Lille Nord de France

M.C. du Puy‐Montbrun

Assistance Publique – Hôpitaux de Paris

P. Moncharmont

Établissement Français du Sang

D. Lyon‐Caen

Institut National de la Transfusion Sanguine

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Établissement Français du Sang

Institut National de la Transfusion Sanguine

Inserm

Sorbonne Université

Centre National de la Recherche Scientifique

Pitié-Salpêtrière Hospital

Assistance Publique – Hôpitaux de Paris

Institut de Veille Sanitaire

Groupe d’Étude de la Matière Condensée

Université Claude Bernard Lyon 1

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Virus de l'hépatite G et produits sanguins labiles : rôle de la transmission transfusionnelle

Transfusion Clinique et Biologique (2004)

Philippe Merle M.H. Elghouzzi Pierre Pradat Fábio Galvão Vidal E. Boiret

Blood donations

10.1016/j.tracli.2004.02.002

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Citations (3)

Dossier patient communiquant transfusionnel

Transfusion Clinique et Biologique (2017)

Marianne Asso‐Bonnet Camille André Pascale Lenet E. Boiret Laura Roggeri

10.1016/j.tracli.2017.06.277

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Citations (0)

GB Virus type C/HGV markers in HCV RNA‐positive French blood donors: correlation with HCV genotypes and risk factors

Transfusion (2000)

Françoise Bouchardeau Syria Laperche Josiane Pillonel M.H. Elghouzzi Patrick Maisonneuve

BACKGROUND: Exposure to GB virus type C/HGV (GBV‐C/HGV) could be determined by detection either of RNA by RT‐PCR or of antibodies of the envelope protein E2. STUDY DESIGN AND METHODS: The aim of the study was to determine the proportion of the GBV‐C/HGV markers of infection in a blood donor population infected with HCV and to identify GBV‐C/HGV routes of transmission that are associated with HCV genotypes and risk factors. RESULTS: Among 306 HCV RNA‐positive blood donors, the proportion of GBV‐C/HGV RNA‐positive donors and anti‐E2‐positive donors was 19.3 percent (95% CI = 15.0‐24.2%) and 42.1 percent (95% CI = 36.6‐47.9%), respectively. Exposure to GBV‐C/HGV (RNA or anti‐E2) was significantly associated with the risk factor of IV drug use. There was a trend toward association with HCV subtypes 1a and 3a, probably because these HCV subtypes are the most frequent in IV drug users. No correlation was observed between ALT elevation and the presence of GBV‐C/HGV RNA. CONCLUSION: In persons with HCV infection, IV drug use seems to be a major route of GBV‐C/HGV transmission. Precautions taken to avoid HCV infection will probably also decrease GBV‐C/HGV transmission.

GB virus C

10.1046/j.1537-2995.2000.40070875.x

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Citations (3)

Hepatitis C Virus: Routes of Infection and Genotypes in a Cohort of Anti‐HCV‐Positive French Blood Donors

Vox Sanguinis (2000)

M.H. Elghouzzi Françoise Bouchardeau Josiane Pillonel E. Boiret C. Tirtaine

Abstract Background: We evaluated and analysed risk factors of HCV‐infected blood donors according to HCV genotypes in order to improve the transfusion policy and safety of blood supply. Materials and Methods: HCV‐RNA was analysed in sera from 518 anti‐HCV‐positive blood donors, who were invited to medical consultation and interview as to risk factors by means of an extensive questionnaire. HCV genotyping was done on all samples positive for HCV‐RNA. Results: Of the 518 sera, 399 (77%) were HCV‐RNA positive, and 394 of 399 HCV genotypes were identified. Major genotypes were 1b (34.3%), 3a (24%), 1a (19.5%) and 2 (11.4%). Of the donors, 289 (55.8%) were interviewed regarding their risk behaviour: 27% were former intravenous drug users (IVDUs), 26% had been transfused, 8% had a history of invasive diagnostic procedures, and 13% a history of surgery. Among the 224 interviewed donors, genotypes 1a and 3a were mainly associated with IVDU (51 and 45% respectively) and genotype 1b, with transfusion and nosocomial infections (40 and 25%, respectively). Conclusion: In this population of anti‐HCV ‐positive blood donors, nosocomial infection may be a route of HCV spread, but the main risk factor remains IVDU, particularly in young men. The transfusion policy will improve if predonation interviews of such young men are done with a specific and sensitive questionnaire.

Hepatitis C

10.1046/j.1423-0410.2000.7930138.x

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Citations (42)

Hepatitis C Virus: Routes of Infection and Genotypes in a Cohort of Anti-HCV-Positive French Blood Donors

Vox Sanguinis (2000)

M.H. Elghouzzi Françoise Bouchardeau Josiane Pillonel E. Boiret C. Tirtaine

We evaluated and analysed risk factors of HCV-infected blood donors according to HCV genotypes in order to improve the transfusion policy and safety of blood supply.HCV-RNA was analysed in sera from 518 anti-HCV-positive blood donors, who were invited to medical consultation and interview as to risk factors by means of an extensive questionnaire. HCV genotyping was done on all samples positive for HCV-RNA.Of the 518 sera, 399 (77%) were HCV-RNA positive, and 394 of 399 HCV genotypes were identified. Major genotypes were 1b (34.3%), 3a (24%), 1a (19.5%) and 2 (11.4%). Of the donors, 289 (55.8%) were interviewed regarding their risk behaviour: 27% were former intravenous drug users (IVDUs), 26% had been transfused, 8% had a history of invasive diagnostic procedures, and 13% a history of surgery. Among the 224 interviewed donors, genotypes 1a and 3a were mainly associated with IVDU (51 and 45% respectively) and genotype 1b, with transfusion and nosocomial infections (40 and 25%, respectively).In this population of anti-HCV-positive blood donors, nosocomial infection may be a route of HCV spread, but the main risk factor remains IVDU, particularly in young men. The transfusion policy will improve if predonation interviews of such young men are done with a specific and sensitive questionnaire.

Hepatitis C

10.1159/000031231

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Citations (48)

O9-3 L'infection par le virus de l'hépatite C (VHC) dans une population de donneurs de sang: génotypes et facteurs de risque

Transfusion Clinique et Biologique (1998)

Françoise Bouchardeau Josiane Pillonel MH Elghouzzi C. Tirtaine Patrick Maisonneuve

10.1016/s1246-7820(98)80147-x

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Citations (1)

BLOOD DONORS AND BLOOD COLLECTION: Testing blood donors for Chagas disease in the Paris area, France: first results after 18 months of screening

Transfusion (2009)

Marie‐Hélène El Ghouzzi E. Boiret Françoise Wind Claudine Brochard Sébastien Fittere

Chagas disease is endemic in Latin America (LA). Currently 10 million people are infected despite World Health Organization efforts aimed at preventing domestic transmission. However, with the migration of infected asymptomatic individuals to nonendemic countries, transmission of Chagas disease by transfusion may become a worldwide problem. The observation that the number of cases of Chagas disease has increased over the past 10 years in French Guiana, together with the results of a previous hospital-based study in the Paris area, confirms the transmission of Chagas disease from patients coming from LA. For these reasons, the French authorities stopped the collection of blood in French Guiana in 2005 and began screening blood donors in the French Caribbean islands and, in 2007, in continental France.Data on birth place, mother's birth place, and travel in LA were recorded for at-risk donors. These subjects were tested using two enzyme-linked immunosorbent assays (ELISAs).Of the 312,458 individuals who gave blood in the Paris area during an 18-month period, 30,837 were tested. Of these, 972 were born in LA, three of whom were positive for the two ELISAs and immunofluorescence tests. The prevalence of Trypanosoma cruzi-positive donors was 9.7 in 100,000 tested donors, but 0.31% among donors born in LA. Serology tests gave discrepant results in 1.02% of the samples.The efficiency of blood donor screening programs could be improved by screening only blood donors who were born in LA or who have traveled in LA for extended periods, using a single enzyme immunoassay.

Chagas Disease

Blood collection

10.1111/j.1537-2995.2009.02476.x

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Citations (42)