Abstract Treatment of the enol ether (I) with (II) and pyridine results in the formation of the cyclopropane derivative (III) (kinetic measurements; discussion of mechanistic implications, also based on the reaction of analogues of (I)).
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract Antifungal activities of a series of allylamines (Figure 1) were correlated with physicochemical parameters describing structural properties, such as lipophilicity, electronic distribution and steric requirements. A large number of physicochemical descriptors were calculated on the basis of a “possible” common conformation for all compounds studied. This conformation was deduced by crystallographic and theoretical studies. By an iteratively used, stepwise, multiple regression analysis (st‐MLR), the initial set of 27 descriptrs could be reduced to a number of 8–9 with only minimal loss of information content. Hence, three highly significant regression equations were established, indcating distinct requirements for the antimycotic activity against three different families of fungi.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure-activity relationships of naphthalene-substituted derivatives of the allylamine antimycotic terbinafinePeter Nussbaumer, Gerhard Dorfstaetter, Ingrid Leitner, Karin Mraz, Hermann Vyplel, and Anton StuetzCite this: J. Med. Chem. 1993, 36, 19, 2810–2816Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/jm00071a011https://doi.org/10.1021/jm00071a011research-articleACS PublicationsRequest reuse permissionsArticle Views894Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract Das aus 19,20‐Dihydromutilin über die Stufen (Ia), (Ib) gut zugängliche Aeylazid (Ic) wird thermisch zu einer Singulett‐ Nitren‐Spezies zersetzt, deren Angriff auf das β‐H‐Atom der Nachbarposition 13 zur Stickstof?nsertion unter Bildung der Verbindung (IIa) liihrt.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
