A. Y. Lee

Korea Institute of Oriental Medicine

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Hyunyong Kim

Texas A&M University

Changjong Moon

Chonnam National University

Dae Sik Jang

Kyung Hee University

Hyun H. Nam

Korea Institute of Oriental Medicine

Sohi Kang

Gyeongsang National University

Sungwook Chae

Korea Institute of Oriental Medicine

Soong-In Lee

Dongshin University

Byeong Cheol Moon

Korea Institute of Oriental Medicine

In Sik Shin

Yonsei University

Goya Choi

Korea Institute of Oriental Medicine

Cooperative Institutions

Korea Institute of Oriental Medicine

Chonnam National University

Seoul National University

Korea University

Kyung Hee University

Chonnam National University Hospital

Jeju National University

Korea University of Science and Technology

Korea Research Institute of Bioscience and Biotechnology

Jeonbuk National University

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Protective Effect of Bojungikki-Tang against Radiation-Induced Intestinal Injury in Mice: Experimental Verification and Compound-Target Prediction

Evidence-based Complementary and Alternative Medicine (2023)

Sohi Kang A. Y. Lee Hyun H. Nam Soong-In Lee Hyunyong Kim

Bojungikki-tang (BJIT) is a traditional herbal medicine used in Korea, Japan, and China to treat gastrointestinal disorders. In this study, we aimed to investigate whether BJIT has protective effects against radiation-induced intestinal injury and to predict the underlying therapeutic mechanisms and related pathways via network pharmacological analyses. BJIT was injected intraperitoneally (50 mg/kg body weight) to C3H/HeN mice at 36 and 12 h before exposure to partial abdominal irradiation (5 Gy and 13 Gy) to evaluate the apoptotic changes and the histological changes and variations in inflammatory cytokine mRNA levels in the jejunum, respectively. Through in silico network analysis, we predicted the mechanisms underlying BJIT-mediated regulation of radiation-induced intestinal injury. BJIT reduced the level of apoptosis in the jejunal crypts 12 h post 5-Gy irradiation. Histological assessment revealed intestinal morphological changes in irradiated mice 3.5 days post 13-Gy irradiation. Furthermore, BJIT decreased inflammatory cytokine levels following radiation exposure. Apoptosis, TNF, p53, VEGF, toll-like receptor, PPAR, PI3K-Akt, and MAPK signaling pathways, as well as inflammatory bowel disease (IBD), were found to be linked to the radioprotective effects of BJIT against intestinal injury. According to our results, BJIT exerted its potential protective effects by attenuating histopathological changes in jejunal crypts and suppressing inflammatory mediator levels. Therefore, BJIT is a potential therapeutic agent that can treat radiation-induced intestinal injury and its associated symptoms.

Jejunum

10.1155/2023/5417813

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Citations (3)

Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E₂ Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages

Journal of Natural Products (2019)

Young Hye Seo Shin-Young Kang Ji-Sun Shin Seung Mok Ryu A. Y. Lee

A new flavone glucoside, acacetin-7-O-(3″-O-acetyl-6″-O-malonyl)-β-d-glucopyranoside (1), two new phenolic glucosides, (3R,7R)-tuberonic acid-12-O-[6′-O-(E)-feruloyl]-β-d-glucopyranoside (14) and salicylic acid-2-O-[6′-O-(E)-feruloyl]-β-d-glucopyranoside (15), and two new phenylpropanoid glucosides, chavicol-1-O-(6′-O-methylmalonyl)-β-d-glucopyranoside (17) and chavicol-1-O-(6′-O-acetyl)-β-d-glucopyranoside(18), as well as 26 known compounds, 2–13, 16, and 19–31, were isolated from the aerial parts of Agastache rugose. The structures of the new compounds were established by spectroscopic/spectrometric methods such as HRESIMS, NMR, and ECD. The anti-inflammatory effect of the isolated compounds was evaluated by measuring their inhibitory activities on prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. New compounds 1, 15, 17, and 18 inhibited LPS-induced PGE2 production with IC50 values of 16.8 ± 0.8, 33.9 ± 4.8, 14.3 ± 2.1, and 48.8 ± 4.4 μM, respectively. Compounds 5, 7, 9−11, 13, 19, 20, 22, and 27–30 showed potent inhibitory activities with IC50 values of 1.7–8.4 μM.

Phenylpropanoid

Acacetin

Glucoside

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10.1021/acs.jnatprod.9b00697

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Citations (20)