Zheng‐Mao Li

Nanjing Medical University

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Da Huo

Nanjing Medical University

Li Zhang

University of California, San Francisco

Guojun Jiang

The First People's Hospital of Xiaoshan District, Hangzhou

Xiang Chen

Northeast Agricultural University

Ruifang Zhu

Beijing Tian Tan Hospital

Heng‐Yi Song

Nanjing Medical University

Wei‐Feng Ye

Children's Hospital of Zhejiang University

Benhui Hu

Nanjing Medical University

Jia‐Wei Li

Nanjing Medical University

Yu Zhang

Nanjing Medical University

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Nanjing Medical University

Capital Medical University

Zhejiang University

Jiangsu Province Hospital

Second Affiliated Hospital of Nanjing Medical University

Nanjing Brain Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Beijing Tian Tan Hospital

Chinese Academy of Sciences

Sichuan University

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Decreased synapse‐associated proteins are associated with the onset of epileptic memory impairment in endothelial CDK5‐deficient mice

MedComm (2022)

Zheng‐Mao Li Xiuxiu Liu Chen Li Zhaocong Wei Yi Shi

Accumulating evidence indicates that epilepsy has a higher risk of inducing memory impairment and dementia. However, the underlying onset mechanism remains unclear. Here, we found that mice with spontaneous epilepsy induced by endothelial CDK5 deficiency exhibited hippocampal-dependent memory impairment at 6 months of age, but not at 2 months of age. Moreover, the persistent epileptic seizures induce aberrant changes in phosphorylation of CaMKII protein in the hippocampus of spontaneous epileptic mice. Using genome-wide RNA sequencing and intergenic interaction analysis of STRING, we found that in addition to epilepsy-related genes, there are changes in synaptic organization pathway node genes, such as

Memory Impairment

10.1002/mco2.128

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